&lt;b&gt;C-reactive Protein and Coronary Artery Disease&lt;/b&gt;

Auer, Johann; Baldassano, Robert N.; Laßnig, Elisabeth; Eber, Bernd

doi:10.1536/jhj.43.607

Cited by 62 publications

(55 citation statements)

References 51 publications

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“…CRP, a factor in systemic inflammatory response, is relevant to the prognosis of KD patients with CAL (27). Serum CRP level is increased in patients with myocardial ischemia and sudden death due to coronary artery disease (28). Previous studies have shown that elevated ESR in KD patients is disadvantageous to the prognosis of CAL (29).…”

Section: Discussionmentioning

confidence: 99%

Plasma MASP-1 concentration and its relationship to recovery from coronary artery lesion in children with Kawasaki disease

Song

Zou

et al. 2015

Pediatr Res

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Background: This study investigated prognostic factors for early recovery of coronary artery lesion (CAL) in children with Kawasaki disease (KD). Methods: Patients hospitalized for KD were enrolled less than 2 wk from the onset of illness and divided into two groups: KD with CAL and KD without CAL. The CAL group was further divided into two subgroups according to the degree of CAL: mild (n = 31) and moderate/severe (n = 6) and further divided into two subgroups according to the age: younger than 1 y (n = 9) and older than 1 y (n = 28). Lectin pathway-related factors MASP-1, CD59, and C5b-9 were measured, along with C-reactive protein, white blood cell counts, erythrocyte sedimentation rate, and platelet count. Patients were followed up for 3 mo. Correlation between the measured factors and the length of time of recovery from CAL was analyzed. results: Plasma concentrations of MASP-1 in the CAL group were significantly lower than those without CAL. MASP-1 and gender positively correlated with the recovery time of CAL. There was no difference in MASP-1 between mild and moderate/severe CAL. At 3-mo follow-up, there was a positive correlation between plasma MASP-1 concentration and recovery time of the patients with CAL older than 1 y. conclusion: Plasma MASP-1 concentration at the early stage of KD is predictive of length of time of recovery from CAL. k awasaki disease (KD), also known as mucocutaneous lymph node syndrome, is an acute nonspecific systemic vascular inflammatory syndrome occurring mainly in children under 5 y of age. A considerable volume of research has shown that the pathological process of KD is characterized by immune activation and immune vasculitis of the vascular endothelial cells (1). KD mostly affects the small and mediumsized arteries, especially the coronary artery (2), resulting in coronary artery lesion (CAL), such as dilation, aneurysm formation, or advanced stenosis, and it is the leading cause of death in children with KD (3). It has been reported that 15-25% of untreated KD patients may develop CAL (4). Although treatment with intravenous immunoglobulin within 10 d of onset of fever reduces the incidence of CAL, 5-8% of patients still develop it. The degree of CAL varies considerably between individuals, ranging from mild to moderate ectasia of the coronary artery to giant aneurysm formation. The recovery time of CAL also differs between patients. There is a very little information about the length of time for which different degrees of CAL persists. Little is known on the relationship between the complement system and the recovery time of CAL resulting from KD. Our previous study indicated that the lectin pathway of the complement system is activated in KD. CAL is associated with endothelial cell dysfunction induced by T-cell activation (5). Endothelial cells are a source of complement-related factors and complement regulatory factors (6), and MASP-1 activates endothelial cells directly, which then activates the complement lectin pathway (7). Endothelial cell dysfunction (8) and com...

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Section: Discussionmentioning

confidence: 99%

Plasma MASP-1 concentration and its relationship to recovery from coronary artery lesion in children with Kawasaki disease

Song

Zou

et al. 2015

Pediatr Res

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“…9,15,[20][21][22][23] Epidemiological studies have shown that CRP levels are a strong independent predictor of risk and an active pathogenic agent of future myocardial infarction, stroke, peripheral arterial disease, and vascular death among persons without known cardiovascular disease. 15) Possible mechanisms of cardiovascular dysfunction with increased levels of CRP have been described recently.…”

Section: Discussionmentioning

confidence: 99%

“…CRP is found within atheromatous plaque, correlates with vascular dysfunction, and promotes the secretion of inflammatory mediators by vascular endothelium. 14,20,21,23) CRP itself induces adhesion molecules and the production of monocyte chemoattractant protein-1 in human endothelial cells and sensitizes endothelial cells to the cytotoxic process by CD4 + T cells. 24,25) We showed that the number of OSAS patients whose CRP levels were above the limits was significantly higher than for non-OSAS patients (5.3% of patients in non-OSAS group and 23.4% in OSAS groups had positive CRP (> 5 mg/L), P = 0.002).…”

Section: Discussionmentioning

confidence: 99%

<b>Elevated C-Reactive Protein Levels and Increased Cardiovascular Risk in Patients With Obstructive Sleep Apnea Syndrome</b>

et al. 2005

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SUMMARYObstructive sleep apnea syndrome (OSAS) is associated with cardiovascular morbidity and mortality. Inflammatory processes associated with OSAS may contribute to cardiovascular morbidity in these patients. C-reactive protein (CRP) is an important serum marker of inflammation. We tested the hypothesis that patients with OSAS have increased plasma CRP.After 173 male subjects underwent polysomnography, 94 were considered to have OSAS (apnea-hypopnea index (AHI) > 5), 38 cardiovascular disease (CVD), and 56 without CVD. Seventy-nine subjects were considered not to have OSAS (AHI < 5) and from among these 57 patients without CVD were enrolled as control subjects.Serum CRP levels were significantly elevated in the OSAS + CVD group compared to the two other groups (P < 0.05). When we evaluated the association between the serum CRP level and severity of OSAS, CRP levels were positively correlated with AHI in OSAS patients (r = 0.61, P < 0.001) OSAS, as a marker of inflammation and cardiovascular risk, is associated with elevated levels of CRP. According to these results, the link between cardiovascular morbidity and OSAS may be explained by the coexistence of other cardiovascular risk factors such as circulating CRP levels. (Int Heart J 2005; 46: 801-809) Key words: CRP, Sleep apnea, Inflammation OBSTRUCTIVE sleep apnea syndrome (OSAS) is a common disorder that affects both children and adults. It is characterized by periods of breathing cessation (apnea) and periods of reduced breathing (hypopnea). Both types of events have similar pathophysiology and are generally considered to be equal with respect to their impact on patients. There are several methods of quantifying the severity of the disorder such as measuring the number of apneas and hypopneas per hour of sleep (the apnea-hypopnea index: AHI), the severity of oxygen desatFrom the

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“…27 Experimental studies have shown that short periods of ischemia followed by reperfusion elicit a cascade of pro inflammatory reactions that include production of oxygen-derived free radicals, activation of the complement system, adherence of the neutrophils to the coronary endothelium, leukocytemediated injury of the myocardial cells, and production of cytokines and acute phase proteins. 28 High sensitivity testing for CRP (hsCRP) has emerged as a convenient tool for detecting low-level systemic inflammation that portends a higher risk of developing atherothrombotic vascular disease in ostensibly healthy men and women and poor short-and long-term prognosis in patients after AMI. 29 American Heart Association guidelines risk stratifies people on the basis of the amount of CRP in blood.…”

Section: Resultsmentioning

confidence: 99%

Acute phase reactants and lipid profile in acute chest pain presentations: a multimarker approach

2016

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<b>C-reactive Protein and Coronary Artery Disease</b>

Cited by 62 publications

References 51 publications

Plasma MASP-1 concentration and its relationship to recovery from coronary artery lesion in children with Kawasaki disease

Plasma MASP-1 concentration and its relationship to recovery from coronary artery lesion in children with Kawasaki disease

<b>Elevated C-Reactive Protein Levels and Increased Cardiovascular Risk in Patients With Obstructive Sleep Apnea Syndrome</b>

Acute phase reactants and lipid profile in acute chest pain presentations: a multimarker approach

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