&lt;b&gt;ANALYSIS OF FK1052, A NEW POTENT 5-HT&lt;sub&gt;3&lt;/sub&gt; AND 5-HT&lt;sub&gt;4&lt;/sub&gt; RECEPTOR DUAL ANTAGONIST, ON ION TRANSPORT OF GUINEA-PIG DISTAL COLON&lt;/b&gt;

Kuwahara, Atsukazu; Kuwahara, Yuko; Kadowaki, Makoto

doi:10.2220/biomedres.15.205

Cited by 8 publications

(2 citation statements)

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“…5HT applied to the mucosal surface of guinea-pig intestine causes the initiation of the peristaltic reflex by excitation of the intrinsic afferent neurons (Bülbring and Lin 1958) and the existence of 5HT receptors on the intrinsic sensory neurons confirms this phenomenon (Kirchgessner et al 1992;Tamir et al 1991;Wade et al 1994). 5HT enhances water and electrolyte secretion in the mucosa by indirect stimulation of both cholinergic and non-cholinergic neurons in the submucous plexus (Cassuto et al 1982;Cook and Reddix 1994;Kuwahara et al 1994). However, it is still not clear whether the above actions can be attributed to 5HT-containing enteric neurons or 5HT-containing enterochromaffin (EC) cells in the epithelium.…”

Section: Introductionmentioning

confidence: 97%

Distribution of serotonin-immunoreactive nerve cells and fibers in the rat gastrointestinal tract

Fujimiya

Okumiya²,

Yamane

et al. 1997

Histochemistry and Cell Biology

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The distribution of serotonin-immunoreactive (5HT-IR) nerve cells and fibers was thoroughly investigated immunohistochemically in the rat stomach, duodenum, jejunum, ileum, and colon. The immunoreactivity of the 5HT neurons was compared between non-treated controls and animals treated with colchicine, colchicine plus 5-hydroxytryptophan (5HTP), colchicine plus pargyline, and reserpine. The intensity of immunoreactivity in nerve fibers as well as nerve cell bodies was enhanced mostly in colchicine plus pargyline treated animals, therefore these animals were used for an observation of precise localization of 5HT in the rat gastrointestinal (GI) tract. Immunoreactivity in the nerve cell bodies and fibers was completely abolished in the GI tract of reserpine treated animals. The pattern of localization and projection of 5HT-IR neurons was similar in all segments of the rat GI tract: 5HT-IR nerve cell bodies were located in the myenteric plexus and showed the distinctive features of Dogiel type I neurons. Prominent bundles of varicose fibers traversed the myenteric ganglia and some of them surrounded the cell bodies of immunopositive and immunonegative neurons. 5HT-IR nerve fibers were located in the submucous plexus, densely entwined about the submucosal blood vessels. Most characteristically, 5HT-IR nerve fibers invaded the lamina propria of mucosa where they underlay the crypt epithelium. In conclusion, the present study showed that 5HT-IR neurons located in the myenteric plexus projected fibers widely in the rat GI tract. The localization of fibers in the lamina propria of mucosa implies that this neuron may exert an important role in the epithelial function of the GI tract.

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Section: Introductionmentioning

confidence: 97%

Distribution of serotonin-immunoreactive nerve cells and fibers in the rat gastrointestinal tract

Fujimiya

Okumiya²,

Yamane

et al. 1997

Histochemistry and Cell Biology

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“…No plexo submucoso a serotonina aumenta a secreção de água e eletrólitos na mucosa por estimulação indireta de ambos os neurônios colinérgicos e não-colinérgicos no plexo submucoso (CASSUTO et al, 1982;COOK;REDDIX, 1994;KUWAHARA;KUWAHA-RA;KADOWAKI, 1994).…”

Section: Inervação Intrínseca Do Sistema Digestório: Sistema Nervoso unclassified

O Eixo Intestino-Cérebro E O Papel Da Serotonina

Vedovato¹,

Trevizan²,

Zucoloto³

et al. 2015

Arq. Ciênc. Saúde Unipar

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VEDOVATO, K.; TREVIZAN, A. R.; ZUCOLOTO, C. N.; BERNARDI, M. D. L.; ZANONI, J. N.; MARTINS, J. V. C. P. O eixo intestinocérebro e o papel da serotonina. Arq. Ciênc. Saúde Unipar, Umuarama, v. 18 n. 1, p. 33-42, jan./abr. 2014 RESUMO: Este trabalho teve por finalidade buscar informações na literatura que descrevam a interação entre o sistema nervoso central (SNC) e sistema nervoso entérico (SNE), e que demonstrem de que forma a serotonina pode atuar no "eixo intestino-cérebro". A serotonina (5-hidroxitriptamina, 5-HT) originalmente descoberta em 1937 por Vittorio Erspamer é uma indolamina, encontrada em células do trato gastrointestinal, plaquetas e no sistema nervoso central de mamíferos, sendo que cerca de 95% da 5-HT corpórea é produzida no intestino. De acordo com a literatura o trato gastrointestinal é inervado por cinco diferentes classes de neurônios: neurônios entéricos, aferentes vagal, aferentes da coluna vertebral, eferentes parassimpáticos e eferentes simpáticos. Os alvos primários da 5-HT que é secretado pelas células enteroendócrinas são as projeções intrínsecas constituída por neurônios aferentes primários da mucosa e plexo mientérico, e projeções extrínsecas, constituída por nervos que transmitem sensações gerais além de náuseas e desconforto para o sistema nervoso central. Após os dados compilados da literatura fica claro que o SNE desempenha papel singular, podendo agir de maneira independente, mas também mantém sinapses com o SNC, por meio do nervo vago. Dessa forma, ambos os sistemas podem influenciar a atividade um do outro mediante o "eixo intestino-cérebro". Adicionalmente a 5-HT apresenta-se como um importante neurotransmissor envolvido na interação entre o SNE o SNC, importante na regulação da sensação de motilidade e secreção intestinal e também atua na ativação e condução da informação ao SNC. PALAVRAS-CHAVE: Sistema nervoso entérico; Sistema nervoso central; Intestino; Serotonina. THE BRAIN-INTESTINE AXIS AND THE ROLE OF SEROTONINABSTRACT: This paper aims to seek literature information describing the interaction between the central and enteric nervous system, and to demonstrate how serotonin may be acting on the "brain-intestine axis." Serotonin, originally discovered in 1937 by Vittorio Erspamer, is an indoleamine found in cells in the gastrointestinal tract, platelets and in the central nervous system of mammals, with approximately 95% of body 5-HT produced in the intestine. According to literature, the gastrointestinal tract is innervated by five different neuron classes: enteric neurons, vagal afferent, spinal afferent, parasympathetic efferent, and sympathetic efferent. The primary targets of serotonin secreted by entero-endocrine cells are the intrinsic projections composed by primary afferent neurons of the mucosa and myenteric plexus, and extrinsic projections, consisting of nerves that send general sensations as well as nausea and general discomfort to the central nervous system. After the data were compiled from the literature, it is clear that the enteric nervous system p...

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Relationship between nitric oxide and non-adrenergic non-cholinergic inhibitory nerves in human lower esophageal sphincter

1997

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Nitric oxide (NO) has recently been shown to be a neurotransmitter in the non-adrenergic non-cholinergic (NANC) inhibitory nerves in the gastrointestinal tract. To clarify the the role of NO in the human lower esophageal sphincter (LES), enteric nerve responses in lower esophageal tissue specimens obtained from patients with esophageal cancer (n = 7) and patients with gastric cancer (n = 6) were investigated. A mechanographic technique was used to evaluate in vitro LES muscle responses to electrical field stimulation (EFS) of adrenergic and cholinergic nerves before and after treatment with various autonomic nerve blockers, including NG-nitro-L-arginine (L-NNA) and L-arginine. Findings were: (1) Cholinergic nerves were those mainly involved in the regulation of enteric- nerve responses to EFS in the steady state, and NANC inhibitory nerves acted on the LES; (2) L-NNA concentration-dependently inhibited the relaxation in response to EFS in the LES; and (3) this inhibitory effect in the LES was reversed by L-arginine. These findings suggest that cholinergic and NANC inhibitory nerves play important roles in regulating contraction and relaxation of the human LES, and that NO plays an important role as a neurotransmitter in NANC inhibitory nerves of the human LES.

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<b>ANALYSIS OF FK1052, A NEW POTENT 5-HT<sub>3</sub> AND 5-HT<sub>4</sub> RECEPTOR DUAL ANTAGONIST, ON ION TRANSPORT OF GUINEA-PIG DISTAL COLON</b>

Cited by 8 publications

References 0 publications

Distribution of serotonin-immunoreactive nerve cells and fibers in the rat gastrointestinal tract

Distribution of serotonin-immunoreactive nerve cells and fibers in the rat gastrointestinal tract

O Eixo Intestino-Cérebro E O Papel Da Serotonina

Relationship between nitric oxide and non-adrenergic non-cholinergic inhibitory nerves in human lower esophageal sphincter

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