LSPR detection of extracellular vesicles using a silver-PDMS nano-composite platform suitable for sensor networks

Raju, Duraichelvan; Bathini, Srinivas; Bădilescu, Simona; Ouellette, Rodney J.; Ghosh, Anirban; Packirisamy, Muthukumaran

doi:10.1080/17517575.2018.1526326

Cited by 8 publications

(13 citation statements)

References 13 publications

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“…Many other platforms, such as arrays of nanoparticles with various shapes, nanohole arrays, etc., are today successfully used for POC purposes. The interested reader may see several comprehensive review papers on this topic, including our own papers [ 52 , 53 , 54 , 55 ]. Medical applications are rapidly coming to the forefront by combining communications and sensor output to deliver new functions.…”

Section: Solid-state Dewetting Of Thin Metal Films: Principle and mentioning

confidence: 99%

Gold Nano-Island Platforms for Localized Surface Plasmon Resonance Sensing: A Short Review

et al. 2020

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Nano-islands are entities (droplets or other shapes) that are formed by spontaneous dewetting (agglomeration, in the early literature) of thin and very thin metallic (especially gold) films on a substrate, done by post-deposition heating or by using other sources of energy. In addition to thermally generated nano-islands, more recently, nanoparticle films have also been dewetted, in order to form nano-islands. The localized surface plasmon resonance (LSPR) band of gold nano-islands was found to be sensitive to changes in the surrounding environment, making it a suitable platform for sensing and biosensing applications. In this review, we revisit the development of the concept of nano-island(s), the thermodynamics of dewetting of thin metal films, and the effect of the substrate on the morphology and optical properties of nano-islands. A special emphasis is made on nanoparticle films and their applications to biosensing, with ample examples from the authors’ work.

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Section: Solid-state Dewetting Of Thin Metal Films: Principle and mentioning

confidence: 99%

Gold Nano-Island Platforms for Localized Surface Plasmon Resonance Sensing: A Short Review

et al. 2020

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“…In comparison with gentamicin release profile (Figures 5 and 6), the slightly lower initial discharge and subsequent release rate stems from the permeability of PDMS and adsorption of silver by the sponge. Based on this particular characteristic of PDMS, other workers manufactured composites of Ag‐PDMS by submerging PDMS layers in a solution of silver nitrate 88,89 . In order to minimize the silver absorption in the drug elution stage, the magnetic porous PDMS may be presaturated with silver prior to the drug loading stage.…”

Section: Discussionmentioning

confidence: 99%

“…Based on this particular characteristic of PDMS, other workers manufactured composites of Ag-PDMS by submerging PDMS layers in a solution of silver nitrate. 88,89 In order to minimize the silver absorption in the drug elution stage, the magnetic porous PDMS may be presaturated with silver prior to the drug loading stage. This could be achieved by immersing the magnetic sponge in a solution of relatively high concentration AgNO 3 .…”

Section: Discussionmentioning

confidence: 99%

Controlled and localized antibiotics delivery using magnetic‐responsive beads for synergistic treatment of orthopedic infection

Shademani

Jackson

Thompson

et al. 2022

J Biomedical Materials Res

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Antibiotic‐loaded bone cement beads have been a reliable passive delivery system for the localized treatment of osteomyelitis; however, low, and unregulated drug release rates limit the ability of this system to maintain therapeutic concentrations. This problem is further amplified by drug‐resistant pathogens that might invade or evolve under these conditions. Furthermore, currently available bone cements are incompatible with some antibiotics. The proposed device resembles conventional bone cement beads but contains an on‐demand drug delivery magnetic sponge that provides actively controlled release of antibiotics. The slightly porous structure facilitates some drug diffusion while further drug release may be controlled remotely via magnetic actuation. Additionally, a combination of silver nitrate and gentamicin are used in the device as these agents are shown to display a synergistic antibacterial activity in vitro using checkerboard and time‐kill assays. The device releases gentamicin and silver in both actuation and diffusion modes over 7 days. The in vitro bacterial studies demonstrate the efficacy of the released agents alone, and synergistically in combination, against Methicillin‐resistant Staphylococcus aureus and Escherichia coli. The proposed device offers a facile fabrication process which allows control of the release profile by engineering hole configurations or manipulating magnetic field strength to provide the most effective therapy.

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“…91 A similar nanoplasmonic platform was also demonstrated by forming silver (Ag) nanoislands on a polydimethylsiloxane substrate. 92 In this structure, resonance peak shifts were measured in absorption spectra.…”

Section: Other Nanostructuresmentioning

confidence: 99%

Plasmonic Sensors for Extracellular Vesicle Analysis: From Scientific Development to Translational Research

et al. 2020

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Extracellular vesicles (EVs), actively shed from a variety of neoplastic and host cells, are abundant in blood, and carry molecular markers from parental cells. For these reasons, EVs have gained much interest as biomarkers of disease. Among a number of different analytical methods that have been developed, surface plasmon resonance (SPR) stands out as one of the ideal techniques given its sensitivity, robustness, and ability to miniaturize. In this review, we compare different SPR platforms for EV analysis, including conventional SPR, nanoplasmonic sensors, surface-enhanced Raman spectroscopy, and plasmonic-enhanced fluorescence. We discuss different surface chemistries used to capture targeted EVs and molecularly profile their proteins and RNAs. We also highlight these plasmonic platforms' clinical applications, including cancers, neurodegenerative diseases, and cardiovascular diseases. Finally, we discuss the future perspective of plasmonic sensing for EVs and their potentials for commercialization and clinical translation.

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LSPR detection of extracellular vesicles using a silver-PDMS nano-composite platform suitable for sensor networks

Cited by 8 publications

References 13 publications

Gold Nano-Island Platforms for Localized Surface Plasmon Resonance Sensing: A Short Review

Gold Nano-Island Platforms for Localized Surface Plasmon Resonance Sensing: A Short Review

Controlled and localized antibiotics delivery using magnetic‐responsive beads for synergistic treatment of orthopedic infection

Plasmonic Sensors for Extracellular Vesicle Analysis: From Scientific Development to Translational Research

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