LSD Modulates Proteins Involved in Cell Proteostasis, Energy Metabolism and Neuroplasticity in Human Cerebral Organoids
Marcelo N. Costa,
Livia Goto-Silva,
Juliana M. Nascimento
et al.
Abstract:The effects of psychedelics encompass modulation of subjective experience, neuronal plasticity, brain activity and connectivity, constituting a complex phenomenon. Underlying these effects, molecular changes at the protein level are expected. Proteomic analysis of human brain cells can elicit a comprehensive view of proteins and biological processes regulated within the central nervous system. To explore the molecular pathways influenced by lysergic acid diethylamide (LSD), we utilized mass spectrometry-based … Show more
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