Abstract:Single-cell RNA sequencing (scRNA-seq) data has been widely used for cell trajectory inference, with the assumption that cells with similar expression profiles share the same differentiation state. However, the inferred trajectory may not reflect true clonal relationships among cells. Single cell T cell receptor sequencing (scTCR-seq) data provides invaluable insights into the clonal relationship among cells, yet it lacks the functional characteristics. Therefore, scRNA-seq and scTCR-seq data complement each o… Show more
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