Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia

Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease

“…17 In addition, the frequency of the p.G2385R variant also tended to be higher in Ad-PD patients than in sPD patients in accordance with a previous study. 40 Taken together, this study reinforced the notion that p.G2385R is a potential risk factor for PD. However, lack of evidences on the cosegregation suggested that other genetic factors should also be involved in the disease pathogenesis in the pedigrees with p.G2385R mutation.…”

“…16,17,[34][35][36][37][38][39] One of these studies included 26 patients with a familial history of PD, among which six patients were p.G2385R carriers. 40 A meta-analysis on the basis of these studies involving 2205 PD patients and 1817 controls demonstrated average carrier rates of 9.3% in PD and 4% in controls. 41 In this study, the frequency of the p.G2385R variant did not reach statistical significance between sPD patients and controls, probably due to relatively small sample size.…”

The LRRK2 Arg1628Pro variant is a risk factor for Parkinson’s disease in the Chinese population

“…This work led to our initial identification of the association of Gly2385Arg with PD, a finding that has been rapidly and consistently replicated in Chinese populations from Singapore [5], Taiwan [6,7], mainland China [8,9], and in the Japanese population [10].…”

Olfactory Dysfunction in Parkinson’s Disease Patients with the LRRK2 G2385R Variant

“…The blood samples were analyzed as described previously [17]. The genotyping for the LRRK2 G2385R variant (7153G[A, single nucleotide polymorphism [SNP] with accession no.…”