LRRC3B polymorphisms contributed to breast cancer susceptibility in Chinese Han Population

Abstract

Purpose LRRC3B gene, as a tumor suppressor gene was involved in the development and progress of breast cancer (BC). However, the effect of LRRC3B polymorphisms on BC has rarely been reported. In the study, we aims to evaluate the relation between LRRC3B variants and BC risk. Methods Among 563 BC patients and 552 healthy controls, ten single-nucleotide polymorphisms (SNPs) in LRRC3B were genotyped by Agena MassARRAY. Odds ratios (OR) and 95% confidence interval (CI) was calculate using logistic regression model. Results Our study demonstrated that rs1907168 polymorphism (OR = 0.71, p = 0.017) reduced the risk of BC in the overall. In stratified analyses by age, rs1907168 decreased (OR = 0.53, p = 0.002) while rs78205284 (OR = 2.83, p = 0.034) increased BC susceptibility among the population at age ≤ 51 years. Clinical parameters such as tumor size, the status of PR and Ki67 were associated with LRRC3B variants. Furthermore, we found that the association of ‘GATT’ haplotype with an increased risk for BC. In addition, LRRC3B gene was down-regulated in BC tumor and had a poor prognosis in BC in silico analysis. Conclusion Our study firstly found LRRC3B SNPs contributed to the risk of BC, suggesting LRRC3B variants might help to predict BC progression.

Efficacy of Lycopene on Aflatoxin B1- Induces Oxidative Stress, Hepatotoxicity, Apoptosis and Immunodeficiency in Japanese Quail

“…Indeed, aflatoxin poisoning has been linked to liver cancer in a number of countries, particularly in Asia and Africa, where grains are more likely to be contaminated with aflatoxin due to favourable humid conditions (6). Previous studies provided evidence that oxidative stress, inflammation, and cell apoptosis play a significant role in AFB 1induced toxicity, suggesting that antioxidants could be used as a convenient approach to limit the progress of the toxic impacts associated with acute AFB 1 toxicity (7). Therefore, there is a dire need for finding antioxidant substances that might be effective in alleviating the deleterious effects of AFB 1 exposure.…”