Lrp5 regulation of bone mass and serotonin synthesis in the gut

Kode, Aruna; Obri, Arnaud; Paone, Riccardo; Kousteni, Stavroula; Ducy, Patricia; Karsenty, G.

doi:10.1038/nm.3698

Cited by 29 publications

(27 citation statements)

References 4 publications

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“…Neuronal SERT is important in regulating serotonergic neurotransmission while mucosal and platelet SERT modulate the paracrine serotonergic signaling of EC cell-derived 5-HT. Platelets may also be important in enabling EC cell-derived 5-HT to act in an endocrine fashion by transporting 5-HT to distant targets such as liver [77] and bone [78]. Following reuptake, 5-HT can be transported into vesicles [79] and reused, or it can be catabolized by a variety of intracellular enzymes including monoamine oxidase (MAO) [80,81].…”

Section: Serotoninmentioning

confidence: 99%

Enteric Neuronal Regulation of Intestinal Inflammation

Margolis

Gershon

2016

Trends in Neurosciences

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Recent research has highlighted the importance of the two-way interaction between the nervous and immune systems. This interaction is particularly important in the bowel because of the unique properties of this organ. The lumen of the gut is lined by a very large but remarkably thin surface that separates the body from the enteric microbiome. Immune defenses against microbial invasion are thus well developed, and neuroimmune interactions are important in regulating and integrating these defenses. Important concepts in the phylogeny of neuroimmunity, enteric neuronal and glial regulation of immunity, changes that occur in the enteric nervous system during inflammation, the fundamental role of serotonin (5-HT) in enteric neuroimmune mechanisms, and future perspectives are reviewed.

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Section: Serotoninmentioning

confidence: 99%

Enteric Neuronal Regulation of Intestinal Inflammation

Margolis

Gershon

2016

Trends in Neurosciences

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“…However, an alternative explanation in which Lrp5-mediated regulation of serotonin production by the enterochromaffin cells of the intestine has also been proposed [45-47]. At early stages of osteoblast differentiation, canonical Wnt signaling is required for commitment to the osteoblast lineage.…”

Section: Role Of Wnt Signaling In Bone Development and Homeostasismentioning

confidence: 99%

Wnt signaling in bone and muscle

Rudnicki

Williams

2015

Bone

117

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“…The new serotonin gut findings have major medical implications for treating osteoporosis, obesity and diabetes. However, the pathways and models proposed are currently controversial since recent studies contradict key findings likely because of strain and murine model differences [54-58]. …”

Section: Fam20c Kinase: a Nexus To The Fap/mvp Pathways And Energy Mementioning

confidence: 99%

A unified model for bone–renal mineral and energy metabolism

Rowe

2015

Current Opinion in Pharmacology

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The beginning of the millennium saw the discovery of a new bone-matrix protein, Matrix Extracellular PhosphogloprotEin (MEPE) and an associated C-terminal motif called ASARM. This motif and other distinguishing features occur in a group of proteins called SIBLINGs. These proteins include dentin matrix protein 1 (DMP1), osteopontin, dentin-sialophosphoprotein (DSPP), statherin, bone sialoprotein (BSP) and MEPE. MEPE, DMP1 and ASARM-motifs regulate expression of a phosphate regulating cytokine FGF23. Further, a trimeric interaction between phosphate regulating endopeptidase homolog X-linked (PHEX), DMP1, and α5β3-integrin that occurs on the plasma-membrane of the osteocyte mediates FGF23 regulation (FAP pathway). ASARM-peptides competitively inhibit the trimeric complex and increase FGF23. A second pathway involves specialized structures, matrix vesicles (MVP pathway). This review will discuss the FAP and MVP pathways and present a unified model for mineral and energy metabolism.

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Lrp5 regulation of bone mass and serotonin synthesis in the gut

Cited by 29 publications

References 4 publications

Enteric Neuronal Regulation of Intestinal Inflammation

Enteric Neuronal Regulation of Intestinal Inflammation

Wnt signaling in bone and muscle

A unified model for bone–renal mineral and energy metabolism

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