LRIG2 expression and prognosis in non-small cell lung cancer

Wang, Guangchuan; Wu, Jie; Song, Huijuan

doi:10.3892/ol.2014.2157

Cited by 15 publications

(24 citation statements)

References 28 publications

(42 reference statements)

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“…The patient samples and the study approval were discussed as previously described. 21 In this study, 36 NSCLC fresh tissue samples and 182 formalin-fixed paraffin-embedded (FFPE) NSCLC tissue samples were obtained between December 2001 and April 2012 from Liaoning Medical University Affiliated First Hospital in China. The patients who had histories of other solid tumors, and/or had incomplete clinicopathological and follow-up data were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, all samples were randomly selected regardless of age, gender, or duration of the diseases, and all cases were diagnosed pathologically. 21 All cases were classified according to the World Health Organization (WHO) revised proposal for histological types of lung cancer. 24 The study was performed with respect to the ethical standards of the 1975 Declaration of Helsinki, as revised in 2000 and was approved by the Ethics Committee of Liaoning Medical University in China.…”

Section: Methodsmentioning

confidence: 99%

“…Lung cancer is the most frequently diagnosed cancer and the leading cause of cancer-related deaths worldwide and is responsible for ∼13% of the total new cases and 18% of the deaths per year. 19 – 21 The majority of this disease is diagnosed as NSCLC, which accounts for >80% of all cases of lung cancer 22 and remains incurable when the cancer cells metastasize to the other organs. Currently, a limited number of studies have investigated the roles of LRIG1 in lung cancer.…”

Section: Introductionmentioning

confidence: 99%

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Expression of LRIG1 is Associated With Good Prognosis for Human Non-small Cell Lung Cancer

Zhao

et al. 2015

Medicine

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Somatic mutations, which are associated with a certain rate of response to targeted therapies, are ubiquitously found in human non-small cell lung cancer (NSCLC). However, it is largely unknown which group of patients may benefit from the respective treatments targeting different somatic mutations. Therefore, more effective prognostic and predictive markers are desperately needed for the treatment of NSCLC harboring different somatic mutations. The leucine-rich repeats and immunoglobulin-like domains (LRIG)-1 is a tumor suppressor gene that belongs to the LRIG family. LRIG1 expression has prognostic significance in various human cancers.In this study, we first used the quantitative polymerase chain reaction (qPCR) and immunohistochemical analysis of 36 and 182 NSCLC patient tissues to analyze the LRIG1 expression respectively. To investigate the prognostic value of LRIG1 in NSCLC, we examined the correlation between clinical features and overall survival (OS) with Cox proportional hazard regression. We also compared the sensitivity and specificity of LRIG1 in NSCLC prognosis by logistic regression to further evaluate the prognostic efficiency of LRIG1 in NSCLC.We found that the LRIG1 expression was associated with pathological type, differentiation status, and stage of NSCLC. The result showed that LRIG1 was an independent prognostic factor for OS of NSCLC patients. LRIG1 in combination with other clinicopathological risk factors was a stronger prognostic model than clinicopathological risk factors alone.Thus, the LRIG1 expression potentially offered a significant clinical value in directing personal treatment for NSCLC patients.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expression of LRIG1 is Associated With Good Prognosis for Human Non-small Cell Lung Cancer

Zhao

et al. 2015

Medicine

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“…In non-small cell lung cancer, LRIG2 mRNA and protein expression were found to be decreased compared to adjacent tissue. Here again, high cytoplasmic staining of LRIG2 was found to be an independent predictor of poor five year survival (Wang et al, 2014). …”

Section: Lrig Expression In Cancermentioning

confidence: 95%

The LRIG family: enigmatic regulators of growth factor receptor signaling

Simion¹,

Cedano-Prieto²,

Sweeney³

2014

Endocrine-Related Cancer

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The LRIG (leucine-rich repeats and immunoglobulin-like domains) family of transmembrane proteins contains three vertebrate members (LRIG1, LRIG2, LRIG3) and one member each in flies (Lambik) and worms (Sma-10). LRIGs have stepped into the spotlight as essential regulators of growth factor receptors, including receptor tyrosine and serine/threonine kinases. LRIGs have been found to both negatively (LRIG1, LRIG3) and positively (Sma-10, LRIG3) regulate growth factor receptor expression and signaling, although the precise molecular mechanisms by which LRIGs function are not yet understood. The most is known about LRIG1, which was recently demonstrated to be a tumor suppressor. Indeed, in vivo experiments reinforce the essential link between LRIG1 and repression of its targets for tissue homeostasis. LRIG1 has also been identified as a stem cell marker and regulator of stem cell quiescence in a variety of tissues, discussed within. Comparably less is known about LRIG2 and LRIG3 although studies to date suggest that their functions are largely distinct from LRIG1 and that they likely do not serve as growth/tumor suppressors. Finally, the translational applications of expressing soluble forms of LRIG1 in LRIG1-deficient tumors are being explored and hold tremendous promise.

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“…Its expression level may have a potential role in the pathogenesis of lung cancer and represents a prognostic value (Wang et al . ). In addition, the RET gene (with which LRIG2 interacts) was also identified as one of the most promising candidate genes underlying this trait in our previous single SNP‐based genome‐wide association study within the same genotype data used here (unpublished data).…”

Section: Discussionmentioning

confidence: 97%

Genome‐wide detection ofCNVs associated with beak deformity in chickens using high‐density 600KSNParrays

et al. 2018

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Beak deformity (crossed beaks) is found in several indigenous chicken breeds including Beijing-You studied here. Birds with deformed beaks have reduced feed intake and poor production performance. Recently, copy number variation (CNV) has been examined in many species and is recognized as a source of genetic variation, especially for disease phenotypes. In this study, to unravel the genetic mechanisms underlying beak deformity, we performed genome-wide CNV detection using Affymetrix chicken high-density 600K data on 48 deformed-beak and 48 normal birds using penncnv. As a result, two and eight CNV regions (CNVRs) covering 0.32 and 2.45 Mb respectively on autosomes were identified in deformed-beak and normal birds respectively. Further RT-qPCR studies validated nine of the 10 CNVRs. The ratios of six CNVRs were significantly different between deformed-beak and normal birds (P < 0.01). Within these six regions, three and 21 known genes were identified in deformed-beak and normal birds respectively. Bioinformatics analysis showed that these genes were enriched in six GO terms and one KEGG pathway. Five candidate genes in the CNVRs were further validated using RT-qPCR. The expression of LRIG2 (leucine rich repeats and immunoglobulin like domains 2) was lower in birds with deformed beaks (P < 0.01). Therefore, the LRIG2 gene could be considered a key factor in view of its known functions and its potential roles in beak deformity. Overall, our results will be helpful for future investigations of the genomic structural variations underlying beak deformity in chickens.

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LRIG2 expression and prognosis in non-small cell lung cancer

Cited by 15 publications

References 28 publications

Expression of LRIG1 is Associated With Good Prognosis for Human Non-small Cell Lung Cancer

Expression of LRIG1 is Associated With Good Prognosis for Human Non-small Cell Lung Cancer

The LRIG family: enigmatic regulators of growth factor receptor signaling

Genome‐wide detection ofCNVs associated with beak deformity in chickens using high‐density 600KSNParrays

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