LPS alters placental inflammatory and endocrine mediators and inhibits fetal neurite growth in affected offspring during late gestation

N-acetylcysteine attenuates lipopolysaccharide-induced impairment in lamination of Ctip2-and Tbr1- expressing cortical neurons in the developing rat fetal brain

“…However, we did observe significantly decreased embryo number (Fig. 2c) and increased ROS and IL-6 levels in amniotic fluid, consistent with previous findings374850. Furthermore, treatment with NAC significantly reduced embryo loss and amniotic fluid ROS and IL-6 levels (Fig.…”

Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood

“…4D). It has been previously reported that pro-inflammatory stimulation inhibits the sprouting of foetal peripheral sympathetic neurons in vitro and in vivo (Nolan et al, 2011;Straley et al, 2014). These findings suggest that chronic PNS can restrict neurite growth in the foetal sympathetic system due to the elevation of circulating pro-inflammatory cytokines, which in turn can result in a deficient sympathetic innervation of target organs, including the large intestine.…”

p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing

“…In a mouse study, Rsv increased uterine arterial blood flow velocity and fetal weight in eNos -/-and Comt -/-mice, suggesting potential as a therapeutic strategy for preeclampsia and fetal growth restriction (22). There is now evidence that an inflammatory stimulus insufficient to induce PTB during the late gestational stage is likely to trigger neurological disorders in the newborn later in life (62,63). It would be interesting to see whethoffering protection against spontaneous and inflammation-exacerbated PTB in p53 d/d mice.…”