LPLUNC1 stabilises PHB1 by counteracting TRIM21-mediated ubiquitination to inhibit NF-κB activity in nasopharyngeal carcinoma

Wang, Heran; Zhou, Yujuan; Oyang, Linda; Han, Yaqian; Xia, Longzheng; Lin, Jingguan; Tang, Yue; Su, Min; Tan, Shiming; Tian, Yutong; Chen, Xiaoyan; Luo, Xin; Liang, Jiaxin; Rao, Shan; Wang, Ying; Xiong, Wei; Zeng, Zhaoyang; Wang, Hui; Li, Guiyuan; Liao, Qianjin

doi:10.1038/s41388-019-0778-6

Cited by 41 publications

(57 citation statements)

References 49 publications

(66 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FAM225A exerts a cancer-promoting role through functioning as a ceRNA and sponging miR-590-3p and miR-1275, causing higher expression of ITGB3 and activation of the FAK/PI3K/Akt pathway [139]. M6A regulates NPC cell proliferation [140,141].…”

Section: M6a Functions As a Tumor Promoter M6a Promotes Expression Ofmentioning

confidence: 99%

Functions of N6-methyladenosine and its role in cancer

et al. 2019

Mol Cancer

916

816

View full text Add to dashboard Cite

N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests that m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis. M6A is installed by m6A methyltransferases, removed by m6A demethylases and recognized by reader proteins, which regulate of RNA metabolism including translation, splicing, export, degradation and microRNA processing. Alteration of m6A levels participates in cancer pathogenesis and development via regulating expression of tumor-related genes like BRD4, MYC, SOCS2 and EGFR. In this review, we elaborate on recent advances in research of m6A enzymes. We also highlight the underlying mechanism of m6A in cancer pathogenesis and progression. Finally, we review corresponding potential targets in cancer therapy.

show abstract

Section: M6a Functions As a Tumor Promoter M6a Promotes Expression Ofmentioning

confidence: 99%

Functions of N6-methyladenosine and its role in cancer

et al. 2019

Mol Cancer

916

816

View full text Add to dashboard Cite

show abstract

“…Hence, the prognosis of these patients is poor (Fan et al ., 2019b; Peng et al ., 2019; Ren et al . 2020; Wang et al ., 2019a; Wei et al ., 2018a,b; Xiong et al ., 2019).…”

Section: Introductionmentioning

confidence: 99%

LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma

et al. 2020

Self Cite

View full text Add to dashboard Cite

Long noncoding RNA (lncRNA) have emerged as crucial regulators for a myriad of biological processes, and perturbations in their cellular expression levels have often been associated with cancer pathogenesis. In this study, we identified AATBC (apoptosis‐associated transcript in bladder cancer, LOC284837) as a novel lncRNA. AATBC was found to be highly expressed in nasopharyngeal carcinoma (NPC), and increased AATBC expression was associated with poor survival in patients with NPC. Furthermore, AATBC promoted migration and invasion of NPC cells in vitro, as well as metastasis in vivo. AATBC upregulated the expression of the desmosome‐associated protein pinin (PNN) through miR‐1237‐3p sponging. In turn, PNN interacted with the epithelial–mesenchymal transition (EMT) activator ZEB1 and upregulated ZEB1 expression to promote EMT in NPC cells. Collectively, our results indicate that AATBC promotes NPC progression through the miR‐1237‐3p–PNN–ZEB1 axis. Our findings indicate AATBC as a potential prognostic biomarker or therapeutic target in NPC.

show abstract

“…Tripartite motif-containing protein 21 (TRIM21), a member of the family of tripartite motif (TRIM)-containing proteins, is a RING finger domain-containing E3 ubiquitin ligase that was first implicated in autoimmune diseases 20 . The dysregulation of TRIM21 contributes to the progression of human malignancies including breast cancer 21,22 . Our data provide compelling evidence that the degradation of SET7/9 by TRIM21 can be used to suppress breast cancer progression.…”

Section: Introductionmentioning

confidence: 99%

SET7/9 promotes multiple malignant processes in breast cancer development via RUNX2 activation and is negatively regulated by TRIM21

Zhou

Zhao

et al. 2020

Cell Death Dis

View full text Add to dashboard Cite

Although the deregulation of lysine methyltransferase (su(var)-3-9, enhancer-of-zeste, trithorax) domain-containing protein 7/9 (SET7/9) has been identified in a variety of cancers, the potential role of SET7/9 and the molecular events in which it is involved in breast cancer remain obscure. Using the online Human Protein Atlas and GEO databases, the expression of SET7/9 was analyzed. Furthermore, we investigated the underlying mechanisms using chromatin immunoprecipitation-based deep sequencing (ChIP-seq) and quantitative ChIP assays. To explore the physiological role of SET7/9, functional analyses such as CCK-8, colony formation, and transwell assays were performed and a xenograft tumor model was generated with the human breast cancer cell lines MCF-7 and MDA-MB-231. Mass spectrometry, co-immunoprecipitation, GST pull-down, and ubiquitination assays were used to explore the mechanisms of SET7/9 function in breast cancer. We evaluated the expression of SET7/9 in different breast cancer cohorts and found that higher expression indicated worse survival times in these public databases. We demonstrated positive effects of SET7/9 on cell proliferation, migration, and invasion via the activation of Runt-related transcription factor 2 (RUNX2). We demonstrate that tripartite motif-containing protein 21 (TRIM21) physically associates with SET7/9 and functions as a major negative regulator upstream of SET7/9 through a proteasome-dependent mechanism and increased ubiquitination. Taken together, our data suggest that SET7/9 has a promoting role via the regulation of RUNX2, whereas TRIM21-mediated SET7/9 degradation acts as an anti-braking system in the progression of breast cancer.

show abstract

LPLUNC1 stabilises PHB1 by counteracting TRIM21-mediated ubiquitination to inhibit NF-κB activity in nasopharyngeal carcinoma

Cited by 41 publications

References 49 publications

Functions of N6-methyladenosine and its role in cancer

Functions of N6-methyladenosine and its role in cancer

LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma

SET7/9 promotes multiple malignant processes in breast cancer development via RUNX2 activation and is negatively regulated by TRIM21

Contact Info

Product

Resources

About