LPA6-RhoA signals regulate junctional complexes for polarity and morphology establishment of maturation stage ameloblasts

Inaba, Akira; Harada, Hidemitsu; Ikezaki, Shojiro; Kumakami-Sakano, Mika; Arai, Haruno; Azumane, Marii; Ohshima, Hayato; Morikawa, Kazumasa; Kano, Kuniyuki; Aoki, Junken; Otsu, Keishi

doi:10.1016/j.job.2022.01.004

Cited by 2 publications

(2 citation statements)

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“…A clinical study in which the CSF was collected from Japanese patients and age-and gender-matched HC, showed that patients with SCZ had considerably decreased levels of LPA and LPLs as well as the associated metabolic enzymes, and these levels were shown to be negatively correlated with a variety of clinical symptoms. The levels of LPA 22:6 in the CSF of the SCZ patients were considerably lower than in the HC, probably due to an anomaly in LPA 22:6 metabolism [62,65].…”

Section: Schizophrenia: Clinical Studies Involving Lpa and Its Receptorsmentioning

confidence: 73%

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The Role of Lysophosphatidic Acid in Neuropsychiatric and Neurodegenerative Disorders

Dedoni,

Camoglio,

Siddi

et al. 2024

Future Pharmacology

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Individuals suffering from diverse neuropsychiatric and neurodegenerative disorders often have comparable symptoms, which may underline the implication of shared hereditary influences and the same biological processes. Lysophosphatidic acid (LPA) is a bioactive phospholipid and a crucial regulator of the development of adult neuronal systems; hence, it may play an important role in the onset of certain diseases such as Alzheimer’s, Parkinson’s disease, and schizophrenia. During development, LPA signaling regulates many cellular processes such as proliferation, survival, migration, differentiation, cytoskeleton reorganization, and DNA synthesis. So far, six lysophosphatidic acid receptors that respond to LPA have been discovered and categorized based on their homology. Despite the abundance of evidence relating LPA cellular activities to different pathological conditions, little is known about the involvement of LPA in the field of neuropsychiatric and neurodegenerative diseases. The purpose of this review is to define LPA activities related to the illnesses stated above in order to better understand these pathologies and provide future novel treatment strategies based on the latest data.

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Section: Schizophrenia: Clinical Studies Involving Lpa and Its Receptorsmentioning

confidence: 73%

“…Moreover, LPAR6 KO animals had faster oligodendrocyte development in the brain, indicating that endogenous LPA adversely affects oligodendrocyte growth [61]. LPA6 is abundant in ameloblasts and ameloblast cell lines, and it improves cell-cell adhesion and cortical actin production in a Rho-dependent way [62].…”

Section: Roles Of Lpa In the Bodymentioning

confidence: 99%