LP-BM5 Retrovirus–Expanded Monocytic Myeloid-Derived Suppressor Cells Alter B Cell Phenotype and Function

Rastad, Jessica L.; Green, William R.

doi:10.4049/immunohorizons.1700066

Cited by 6 publications

(4 citation statements)

References 103 publications

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“… 33 Also, they suppress antigen presentation to antigen‐specific CD4 + T cells by inhibiting CD40 and HLA‐DR expression on stimulated B cells. 34 An increase in M‐MDSCs has been reported in patients with hepatitis B virus, hepatitis C virus and human immunodeficiency virus. 21 , 35 , 36 The expansion of M‐MDSCs has been observed in chronic viral diseases, indicating that MDSCs contribute to the establishment of chronic infection.…”

Section: Discussionmentioning

confidence: 99%

“…M‐MDSCs are known to specifically suppress virus‐specific CD8 + T cell activation and lead to delayed viral clearance 33 . Also, they suppress antigen presentation to antigen‐specific CD4 + T cells by inhibiting CD40 and HLA‐DR expression on stimulated B cells 34 . An increase in M‐MDSCs has been reported in patients with hepatitis B virus, hepatitis C virus and human immunodeficiency virus 21,35,36 .…”

Section: Discussionmentioning

confidence: 99%

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Correlation of myeloid‐derived suppressor cells with C‐reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID‐19

et al. 2021

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The novel coronavirus disease 2019 (COVID‐19) remains a global health emergency, and understanding the interactions between the virus and host immune responses is crucial to preventing its lethal effects. The expansion of myeloid‐derived suppressor cells (MDSCs) in COVID‐19, thereby suppressing immune responses, has been described as responsible for the severity of the disease, but the correlation between MDSC subsets and COVID‐19 severity remains elusive. Therefore, we classified patients according to clinical and laboratory findings—aiming to investigate the relationship between MDSC subsets and laboratory findings such as high C‐reactive protein, ferritin and lactate dehydrogenase levels, which indicate the severity of the disease. Forty‐one patients with COVID‐19 (26 mild and 15 severe; mean age of 49.7 ± 15 years) and 26 healthy controls were included in this study. MDSCs were grouped into two major subsets—polymorphonuclear MDSCs (PMN‐MDSCs) and monocytic MDSCs—by flow cytometric immunophenotyping, and PMN‐MDSCs were defined as mature and immature, according to CD16 expressions, for the first time in COVID‐19. Total MDSCs, PMN‐MDSCs, mature PMN‐MDSCs and monocytic MDSCs were significantly higher in patients with COVID‐19 compared with the healthy controls ( P < .05). Only PMN‐MDSCs and their immature PMN‐MDSC subsets were higher in the severe subgroup than in the mild subgroup. In addition, a significant correlation was found between C‐reactive protein, ferritin and lactate dehydrogenase levels and MDSCs in patients with COVID‐19. These findings suggest that MDSCs play a role in the pathogenesis of COVID‐19, while PMN‐MDSCs, especially immature PMN‐MDSCs, are associated with the severity of the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Correlation of myeloid‐derived suppressor cells with C‐reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID‐19

et al. 2021

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“…4B). 76,77 This study demonstrated that the co-administration of an additional adjuvant induces nonspecific immune responses to interfere with the antigen-selective immune responses.…”

Section: Discussionmentioning

confidence: 91%

Precise immunological evaluation rationalizes the design of a self-adjuvanting vaccine composed of glycan antigen, TLR1/2 ligand, and T-helper cell epitope

et al. 2022

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“…The relevance of the monocytic MDSC‐subset with respect to regulation of B‐cell responses has already been pointed out by many studies in mice . Nevertheless, the direct effects of M‐MDSCs on the proliferation and function of human B cells were elusive.…”

Section: Discussionmentioning

confidence: 99%

Human monocytic myeloid‐derived suppressor cells impair B‐cell phenotype and function in vitro

et al. 2019

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Myeloid‐derived suppressor cells (MDSCs) are key regulators of immunity that initially have been defined by their ability to potently suppress T‐cell responses. Recent studies collectively demonstrate that the suppressive activity of MDSCs is not limited to T cells, but rather affects a broad range of immune cell subsets. However, relatively few studies have assessed the impact of MDSCs on B cells, particularly in the human context. Here, we report that human monocytic MDSCs (M‐MDSCs) significantly interfere with human B‐cell proliferation and function in vitro. We further show that the inhibition occurs independent of direct cell‐contact and involves the expression of suppressive mediators such as indoleamine 2, 3‐dioxygenase (IDO), arginase‐1 (Arg1), and nitric oxide (NO). In addition, our studies demonstrate that the suppression of B cells by M‐MDSCs is paralleled by a skewing in B‐cell phenotype and gene expression signatures. M‐MDSCs induced the downregulation of key surface markers on activated B cells, including IgM, HLA‐DR, CD80, CD86, TACI, and CD95. Concurrently, M‐MDSCs but not conventional monocytes elicited alterations in the transcription of genes involved in apoptosis induction, class‐switch regulation, and B‐cell differentiation and function. In summary, this study expands our understanding of the regulatory role of M‐MDSCs for human B‐cell responses.

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LP-BM5 Retrovirus–Expanded Monocytic Myeloid-Derived Suppressor Cells Alter B Cell Phenotype and Function

Cited by 6 publications

References 103 publications

Correlation of myeloid‐derived suppressor cells with C‐reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID‐19

Correlation of myeloid‐derived suppressor cells with C‐reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID‐19

Precise immunological evaluation rationalizes the design of a self-adjuvanting vaccine composed of glycan antigen, TLR1/2 ligand, and T-helper cell epitope

Human monocytic myeloid‐derived suppressor cells impair B‐cell phenotype and function in vitro

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