Lp(a) Lipoproteins and the Genetic Polymorphisms of Lipoprotein B

Turnover of Lipoprotein (a) in Man

“…Lp(a), however, contains an additional, specific Lp(a) antigen, which is dissociable from apolipoprotein B by several agents (5,10). In contrast to apolipoprotein B, the specific Lp(a) antigen is soluble in 6 M urea (11). By ultracentrifugation Lp(a) is found in the fraction of density 1.055-1.110 g/ml (11), which is somewhat higher than the density of LDL and overlaps that of LDL and high density lipoproteins (HDL).…”

“…When the lipoprotein (a) [Lp(a)]' was first described (1), it was considered a genetic variant of low density Received for publication 15 Atuguist 1979 and in revised form 11 December 1979. 1 Abbreviations uised in this paiper: FCR, fractional catabolic rate; HDL, high density lipoprotein; LDL, low density lipoprotein; Lp(a), lipoprotein (a); VLDL, very low density lipoprotein.…”

The assembly of lipoprotein Lp(a)

“…Lp(a), originally considered a genetic variant of ' -lipoprotein' ( low-density lipoprotein, LDL), is in fact a chimeric particle that consists of LDL and the glycoprotein apo(a) [1][2][3][4]. Despite intensive work in numerous laboratories, the physiological role of Lp(a) remains elusive.…”

Lipoprotein (a) – An Overview

“…Measurements of serum Lp(a) levels of patients suffering from liver disease or from cholestasis who showed significantly lower concentrations than healthy controls gave indications that Lp(a) might be synthesized by the liver [6]. On the other hand there are studies which suggest that apo-a is associated with the postprandial d < 1.006 lipoproteins induced by fat feeding [7] but it is not yet clear however whether apo-a determined in this fraction is really of intestinal origin or whether it originates from free apo-a in serum which might bind to freshly secreted chylomicrons [8].…”