Lp(a) Lipoprotein in Patients with Acute Stroke

Abstract

Serum lipoprotein(a) [Lp(a)] was determined in 205 patients (71 ± 10 years; mean age ± SD) with acute stroke and in 204 nonhospitalized referent subjects in the 60- to 80-year age range. Lp(a) levels were significantly higher in the stroke patients (median 87 vs. 63 mg/l; p = 0.002). Within the group of stroke patients, Lp(a) levels were similar among men and women, correlated modestly with age (r = 0.15; p = 0.04) and increased only marginally through the first days after stroke. Patients with concomitant ischemic heart disease tended to have higher Lp(a) than those without coronary disease (median 103 vs. 71 mg/l; p = 0.07). Hypertensive patients had higher levels than normotensives (97 vs. 73 mg/l; p = 0.02) and this relation between hypertension and Lp(a) was particularly strong among patients below 65 years of age (p = 0.01). Median Lp(a) level was 75 mg/l in patients not on beta blocker treatment, 103 mg/l in patients on selective beta blockers and 150 mg/l in those on nonselective beta blockers. In a multiple regression model, the use of beta blockers was a predictor of high Lp(a) levels (p = 0.03) that was independent of other clinical variables.

Lipoprotein and apolipoprotein profile in men with ischemic stroke. Role of lipoprotein(a), triglyceride-rich lipoproteins, and apolipoprotein E polymorphism.

“…In the present study no association was found between Lp(a) concentration and hypertension. Such an association has been recently described by Asplund et al, 46 who partially attributed this association to the use of /3-blockers.…”

Lipoprotein (a) as a risk factor of ischemic stroke: a case-control study

“…This was similar to the study conducted by Pedro-Botet et al 16 Such an association has been recently described by Asplund et al in this study, menopausal status was the strongest independent predictor of Lp (a) level in women (p = 0.010), also concluded that hypertensive subjects treated with diuretics had significantly higher Lp (a) than hypertensive on other agents. 17 Study finding supports the hypothesis that lipoprotein (a) is a marker for atherosclerosis. Since genetic factors may influence the concentration of the protein moiety more than environmental factors, genetic factors may have a significant role in determining the predisposition to stroke prevalence.…”

Lipoprotein(a) and ischemic cerebrovascular disease in young adults.

“…20 Among all subjects in this study, only one patient with lacunar stroke was taking a /3-blocker (oral arotinolol hydrochloride, 20 mg/day), which has been shown to increase serum Lp(a) levels. 21 However, the /3-blocker was thought to have little or no effect on this study because the serum Lp(a) level of this patient was very low (5 mg/dL).…”