Lp(a), ApoB and ApoB/ApoA1 Ratio as Potential Serum Markers for Predicting Early-Onset Acute Coronary Syndrome

James, Rebecca; Appunni, Sandeep

doi:10.18410/jebmh/2019/572

Cited by 1 publication

(1 citation statement)

References 33 publications

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“…In the study carried out by Hong et al on 280 patients with NSTEMI who underwent PCI; Apo B and Apo B/Apo A1 ratios were associated with the total occlusion of infarction-related artery in the cases [ 20 ]. More recently, Rebecca et al conducted research on 75 cases with ACS and 69 controls, and they suggested that adding ApoB and ApoB/ApoA1 to the traditional lipid profile would be more helpful in predicting early onset ACS [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

The relation between ApoB/ApoA-1 ratio and the severity of coronary artery disease in patients with acute coronary syndrome

2021

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Background Apolipoprotein B is considered the primary protein constituent of low-density lipoprotein. LDL contains variable quantities of cholesterol, but each lipoprotein contains a single ApoB protein. Thus, ApoB is a better index for the LDL circulation if compared to LDL cholesterol. On the contrary, apolipoprotein A-1 is a main structural protein of high-density lipoprotein. It has a major role in reversing cholesterol flow and cellular cholesterol homeostasis once detected. The aim of the study is to measure apo B/apo A-1 ratio in patients with acute coronary syndrome and assess its relationship with the severity of CAD. A total of 90 patients were enrolled in the study and subdivided into 3 groups: 30 patients of STEMI, 30 patients of NSTEMI, and 30 patients presented with unstable angina. Serum levels of apolipoprotein A-1 and apolipoprotein B were properly measured upon admission, and apo B/apo A-1 ratio was calculated. Results Both of Apo B and Apo B/Apo A1 ratio correlated significantly with Gensini scores (P value <0.001). High Gensini score patients had significantly high Apo B/Apo A1 ratio with the best cutoff value of 0.8 with sensitivity of 90% and specificity of 70%. Conclusion Apo B is an independent risk predictor for the severity of CAD in patients with acute coronary syndromes. Moreover, the Apo B/Apo A1 ratio remains highly significant in patients with high Gensini score.

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Section: Discussionmentioning

confidence: 99%