LOXL1 Deficiency in the Lamina Cribrosa as Candidate Susceptibility Factor for a Pseudoexfoliation-Specific Risk of Glaucoma

Schlötzer‐Schrehardt, Ursula; Hammer, Christian; Krysta, Anita; Hofmann-Rummelt, Carmen; Pasutto, Francesca; Sasaki, Takako; Kruse, Friedrich E.; Zenkel, Matthias

doi:10.1016/j.ophtha.2012.03.015

Cited by 80 publications

(62 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…21,22 Schlötzer-Schrehardt et al 9 found a significant downregulation of lysyl oxidase-like 1 and elastic fiber in LC tissues obtained from early and late stages of pseudoexfoliation syndrome without and with glaucoma when compared with normal and POAG specimens. 9 These alterations may lead to reduced elasticity of the LC 11 and may place PXS patients at 26,27 found significant associations between the peripheral outward deformation of the LC and the presence of a disc hemorrhage with a faster rate of RNFL thinning in POAG patients. In our study, we found peripheral posterior displacement of the LC in nonglaucomatous PXS eyes.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that in PXS, a primary disturbance of the elastic fiber homeostasis in this structure may lead to decreased stiffness and increased deformability of the ONH, rendering PEX eyes more vulnerable to pressure-induced optic nerve damage and glaucoma development and progression. [9][10][11] The nutrition of the choroid could be another possible source of vulnerability of PXS eyes to develop glaucoma. As an analogy, some histologic studies have demonstrated decreased density of capillaries and large choroidal vessels as well as choroidal thinning in advanced primary angle closure glaucoma.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Lamina Cribrosa and Choroid in Nonglaucomatous Patients With Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography

Moghimi

Mazloumi

Johari

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Citation: Moghimi S, Mazloumi M, Johari MK, et al. Evaluation of lamina cribrosa and choroid in nonglaucomatous patients with pseudoexfoliation syndrome using spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2016;57:129357: -130057: . DOI:10.1167 PURPOSE. To evaluate the lamina cribrosa (LC) and peripapillary choroid in patients with pseudoexfoliation syndrome (PXS). METHODS.In this cross-sectional study, one eye each of 32 nonglaucomatous PXS cases and 29 healthy volunteers were enrolled. The optic discs were scanned using enhanced depth imaging spectral-domain optical coherence tomography, and measurements were obtained using HEYEX software 6.0. LC and other related variables at three areas (mid-superior, center, and mid-inferior) and peripapillary choroidal thickness were determined. Linear mixed modeling was used to adjust the variables. RESULTS.After adjustment for age, sex, and axial length, there was no significant difference between the two groups in peripapillary choroidal thickness or in retinal nerve fiber layer thickness. The LC was significantly thinner in all three areas in the PXS group when compared with the control group, even after adjustment. Although no significant difference in central laminar depth was observed between the two groups (P ¼ 0.74), the superior and inferior laminar depth were significantly deeper in the PXS group when compared with the control group (P ¼ 0.04 and P ¼ 0.006, respectively). Although there was a significant negative association between age and central choroidal thickness in the control group (b ¼ À2.820, P ¼ 0.02), this correlation was not significant in the PXS group.CONCLUSIONS. We found that LC is significantly thinner in all three areas of the optic nerve head in nonglaucomatous PXS patients than in controls. Although no significant difference in peripapillary choroidal thickness was observed between the two groups, peripheral posterior displacement of LC in nonglaucomatous PXS eyes was noted.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Evaluation of Lamina Cribrosa and Choroid in Nonglaucomatous Patients With Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography

Moghimi

Mazloumi

Johari

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Recently, some studies have reported that a deficiency in exon 1 of lysyl oxidase-like protein 1 ( LOXL1 ) on chromosome 15q24.1 is associated with an increased vulnerability to optic nerve damage and glaucoma progression in PXS eyes [39,40] . LOXL1 catalyzes the formation of elastin fibers, which are major components of PXS lesions.…”

Section: Discussionmentioning

confidence: 99%

Retinal Nerve Fiber Layer Thickness Changes in the Pseudoexfoliation Syndrome: A Meta-Analysis of Case-Control Studies

et al. 2017

View full text Add to dashboard Cite

Purpose: To evaluate and compare changes in retinal nerve fiber layer (RNFL) thickness in patients with the pseudoexfoliation syndrome (PXS) and healthy controls. Methods: Case-control studies were selected through an electronic search of the Cochrane Controlled Trials Register, PubMed, and Embase. Results were reviewed to ensure that the included studies met prespecified inclusion/exclusion criteria, and the quality of each study was assessed using the Newcastle-Ottawa Scale. All included studies measured average and 4-quadrant (temporal, superior, nasal, and inferior) RNFL thickness using optical coherence tomography (OCT). For the continuous outcomes, we calculated the weighted mean difference (WMD) and 95% confidence intervals (CIs). Results: Eight case-control studies were included in this meta-analysis involving 225 eyes of PXS patients and 208 eyes of healthy controls in total. Statistical analysis revealed that the average RNFL thickness in PXS patients was significantly reduced compared to healthy controls (WMD = −6.91, 95% CI: −9.99 to −3.82, p < 0.0001). Additionally, differences in RNFL thickness in the superior quadrant (WMD = −10.68, 95% CI: −16.40 to −4.95, p = 0.0003), inferior quadrant (WMD = −8.20, 95% CI: −10.85 to −5.55, p < 0.00001), nasal quadrant (WMD = −3.05, 95% CI: −5.21 to −0.90, p = 0.005), and temporal quadrant (WMD = −6.39, 95% CI: −9.98 to −2.80, p = 0.0005) were all significant between the two groups. Conclusions: These results suggest that it is important to evaluate RNFL thickness and the optic nerve head through OCT in patients with PXS in order to determine early glaucomatous damage and start timely intervention prior to visual field loss.

show abstract

“…Widespread elastosis in connective tissue of the lamina cribosa in eyes with PXF further contributes to glaucomatous progression by impeding the lamina cribosa's ability to adapt to IOP fluctuations. 17 Deposition of PXM also is a well-known risk factor for lens dislocation because of friability and decreased tensile strength of zonular fibers. 18,19 The risk of zonulolysis remains in pseudophakic eyes with posterior chamber IOL implants because of the underlying pathology of ongoing PXM deposition disrupting zonules at various levels.…”

Section: Discussionmentioning

confidence: 99%

Inter-Eye Differences in Patients with Pseudoexfoliation Syndrome Presenting with Intraocular Lens Dislocation

Leung¹,

Singh²,

Ahmed³

2015

Ophthalmology

View full text Add to dashboard Cite

LOXL1 Deficiency in the Lamina Cribrosa as Candidate Susceptibility Factor for a Pseudoexfoliation-Specific Risk of Glaucoma

Cited by 80 publications

References 41 publications

Evaluation of Lamina Cribrosa and Choroid in Nonglaucomatous Patients With Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography

Evaluation of Lamina Cribrosa and Choroid in Nonglaucomatous Patients With Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography

Retinal Nerve Fiber Layer Thickness Changes in the Pseudoexfoliation Syndrome: A Meta-Analysis of Case-Control Studies

Inter-Eye Differences in Patients with Pseudoexfoliation Syndrome Presenting with Intraocular Lens Dislocation

Contact Info

Product

Resources

About