LOXHD1 is indispensable for coupling auditory mechanosensitive channels to the site of force transmission
Pei Wang,
Katharine K. Miller,
Enqi He
et al.
Abstract:Hearing is initiated in hair cells by the mechanical activation of ion channels in the hair bundle. The hair bundle is formed by stereocilia organized into rows of increasing heights interconnected by tip links, which convey sound-induced forces to stereocilia tips. The auditory mechanosensitive channels are complexes containing at least four protein-subunits – TMC1/2, TMIE, CIB2, and LHFPL5 – and are located at the tips of shorter stereocilia at a yet-undetermined distance from the lower tip link insertion po… Show more
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