Lowering of Plasma Cholesterol and Enhanced Sterol Excretion with the Consumption of Polyunsaturated Ruminant Fats

Lipid-lowering effects of a modified butter-fat: a controlled intervention trial in healthy men

“…There have been a number of earlier trials in which ruminant fats (meat and dairy) have been modified (Nestel et al, 1973;Nestel & Havenstein, 1974;Hodges et al, 1975;Stein et al, 1975;Vivian & Fulton, 1975;Brown & de Wolf, 1976) but few where bovine feeding has been used to modify milk fat alone. In the two previous studies (Noakes et al, 1996;Tholstrup et al, 1998) which have investigated changes in cardiovascular risk achieved by feeding modified dairy products alone, the findings have been equivocal.…”

“…Dairy products comprise a considerable proportion of the diet in countries such as the United States, Europe and New Zealand and thus make an excellent tool through which reductions in adverse lipid and lipoprotein profiles may possibly be achieved. Three previous bovine feeding trials in Australia and Europe have investigated the effect of a reduced-saturates dairy diet on serum lipid profile and associated CVD risk factors, using a range of methods and with conflicting outcomes (Nestel et al, 1973;Noakes et al, 1996;Tholstrup et al, 1998). Only the Danish trial investigated the effect of modifying butter-fat alone, and this trial failed to show an improvement in risk profile (Tholstrup et al, 1998).…”

Effect of dietary long-chain fatty acids on the rates of cholesterol turnover processes, cholesterol origin and distribution in the rat intestinal lumen

“…1) (Chevallier, 1967 ;Lutton, 1976). The,results in the literature are conflicting, but most studies in man (Moore et al, 1968 ;Connor et al, 1969 ;Nestel, Havenstein and Whyte, 1973 ;Nestel et al, 1975) and in rat (Danielsson and Tchen, 1968) , a relationship between cholesterol synthesis (m s y) and the absorption coefficient was established (25 groups of rats out of 30 assessed as « typical » rats).…”

Long-term effect of medium-chain trigly-ceride on hepatic enzymes catalyzing lipogenesis and cholesterogenesis in rats.

“…It has been widely accepted that a diet containing an EFA such as linoleic acid is useful for achieving a lowering of serum cholesterol and triglyceride in humans (1). However, it can not be overlooked that a tendency to overweight is often complicated because of the inevitable availability of energy supplying linoleate-containing fats.…”