Lowering glucose enhances BACE1 activity and Aβ generation in mouse brain slice cultures
Olivia Sheppard,
Robert Humphrey,
Claire S. Durrant
et al.
Abstract:Numerous environmental risk factors are now recognised as contributors to the onset and progression of Alzheimer's disease (AD). It is probable that, in most instances, AD arises from a combination of genetic predisposition and environmental influences. In particular, there is a strong correlation between vascular impairment and dementia, yet the specific mechanisms by which vascular impairment and AD are linked, remain unknown. Hypoglycaemia can occur both due to vascular impairment, and due to fluctuating gl… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.