Lowering Effects of Allyl Isothiocyanate on the Number of Lymphocyte and Its Subsets in Rats

Imaizumi, Kazunori; Sakakibara, Yuko; Sasaki, Hiromi; Sato, Shogo; Takei, Yumi; Hiruma, Kenji; Ban, Takamasa; Kawashima, Yu; Tanihata, Jun; Tachiyashiki, Kaoru

doi:10.1248/jhs.56.347

Cited by 4 publications

(5 citation statements)

References 35 publications

(78 reference statements)

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“…On the other hand, DHC-induced rises of plasma glucose, FFA and glycerol levels may be caused by the activisceral organs, respectively, through activation of sympathetic nervous system in rats. Further, DHC-induced response levels of glucocorticoid secreted from adrenal cortex may play an important role in higher plasma glucose, FFA and glycerol levels (Imaizumi et al, 2010a(Imaizumi et al, , 2010b. However, these possibilities are not yet elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…The present study was carried out in accordance with the "Guiding Principles for the Care and the Physiological Society of Japan (2004). This study was performed with least possible pain or discomfort to the rats (Akimoto et al, 2009;Aritoshi et al, 2010;Imaizumi et al, 2010aImaizumi et al, , 2010bNomura et al, 2008;Shirato et al, 2006Shirato et al, , 2007Someya et al, 2009). …”

Section: Experimental Protocol and Animal Carementioning

confidence: 99%

“…Plasma glucose, FFA and glycerol concentrations were assayed out on day 0, 1, 3, 7 and 10, and blood samples (collected blood volume = 100 μl) were collected from tail vein on 3 hr post s.c. injection (Akimoto et al, 2009;Aritoshi et al, 2010;Imaizumi et al, 2010aImaizumi et al, , 2010b.…”

Section: Plasma Glucose Ffa and Glycerol Assaysmentioning

confidence: 99%

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Capsaicinoids-induced changes of plasma glucose, free fatty acid and glycerol concentrations in rats

et al. 2011

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-Red peppers are used as a spice for enhancing the palatability of foods. Two major capsaicinoids, dihydrocapsaicin (DHC) and capsaicin (CAP) are responsible for up to 90% of the total pungency of pepper fruits. These capsaicinoids are known to enhance energy metabolism and thermogenesis. However, there is a little information on the effects of capsaicinoids on the lipolysis and carbohydrate metabolism. We studied the effects of DHC and CAP on plasma glucose, free fatty acid (FFA) and glycerol concentrations in rats. Male six-week-old Sprague Dawley rats were divided into the DHC, CAP and control groups. Each capsaicinoid (dose = 3 mg/kg BW/day) was subcutaneously administered to rats for 10 days. DHC increased markedly plasma glucose, FFA and glycerol concentrations on day 1-10 by 14-35%, 61-103% and 108-174%, respectively, as compared with those of the control group. CAP increased relatively plasma glucose concentrations on day 1-3 by 15-17%, as compared with the control group.groups. On the contrary, CAP did not change plasma FFA and glycerol concentrations on day 1-3. However, CAP increased markedly plasma FFA and glycerol concentrations on day 7-10 by 54-89% and 92-98%, respectively, as compared with the control group. DHC and CAP did not change the weights of white (perirenal and periepididymal) and brown (interscapular) adipose tissues. In conclusion, the effects of capsaicinoids on plasma glucose, FFA and glycerol concentrations were relatively higher in the DHC than in the CAP, and capsaicinoids did not change the weight of white and brown adipose tissues.

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Section: Discussionmentioning

confidence: 99%

Section: Experimental Protocol and Animal Carementioning

confidence: 99%

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Capsaicinoids-induced changes of plasma glucose, free fatty acid and glycerol concentrations in rats

et al. 2011

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“…Lighting was had free access to food and water all the time. The body weight, and food intake and water intake were determined at 9:00-10:00 a.m. each day Imaizumi et al, 2010aImaizumi et al, , 2010bOhkaru et al, 2010;Someya et al, 2009). ZDF and the control diet group were pair-fed for 4 weeks with the ZDF and the normal diet, respectively.…”

Section: Introductionmentioning

confidence: 99%

Dietary zinc-deficiency and its recovery responses in rat liver cytosolic alcohol dehydrogenase activities

et al. 2011

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feeding and its recovery on liver cytosolic alcohol dehydrogenase (ADH; alcohol: NAD + oxidoreductase, EC1.1.1.1) activities and plasma zinc levels in rats. The weaned male Sprague Dawley rats were ran-----recovery period were observed between both groups. Plasma zinc concentration in the recovery period was almost recovered to the control level. These results suggest that rat liver cytosolic ADH activity was clearly related to dietary zinc intake levels.Liver alcohol dehydrogenase, Class I ADH, Plasma zinc, Rat

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“…However, the overall responses of the number of white blood cells, and plasma zinc and corticosterone levels in the recovery from dietary zinc-deficiency are still unknown. These questions are of critical importance to understanding of the distribution of white blood cells as an index of the immune-responses of the body defense system (7)(8)(9)(10)(11)(12). In the present study, therefore, we studied the effects of the recovery from dietary zinc-deficiency on the distribution of the number of total white blood cells (WBCs), neutrophils, eosinophils, and basophils, and plasma zinc and corticosterone concentrations in weanling male rats.…”

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confidence: 98%

Different Recovery Responses from Dietary Zinc-Deficiency in the Distribution of Rat Granulocytes

Sakakibara

Sato

Kawashima

et al. 2011

J Nutr Sci Vitaminol

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SummaryThe purpose of this study was to elucidate the effects of the recovery from dietary zinc-deficiency on the number of total white blood cells (WBCs), neutrophils, eosinophils and basophils, and plasma zinc and corticosterone concentrations in weanling male Sprague Dawley rats. Rats ( n ϭ 34) of the zinc-deficient diet (0.6 mg zinc/kg diet) and control diet (35.2 mg zinc/kg diet) groups were fed for 4 wk, and then rats of both groups were fed with the control diet for 3 wk. Zinc-deficiency increased duration-dependently and clearly the number of total WBCs, neutrophils and eosinophils, and the increased numbers of these cells recovered to the control levels in week 2 of the recovery. On the other hand, the number of basophils increased by the zinc-deficiency recovered to the control levels in week 1 of the recovery. Zinc-deficiency significantly decreased plasma zinc concentrations by 85%, and markedly increased plasma corticosterone concentrations by 317%, as compared with the control group. In the recovery period, plasma zinc and corticosterone concentrations recovered to the control levels in week 2 of the recovery. These results suggest that zinc-deficiency and its recovery responses in the number of granulocytes and total WBCs are reversible, and their recovery rates depend on the subsets of granulocytes in rats.

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Lowering Effects of Allyl Isothiocyanate on the Number of Lymphocyte and Its Subsets in Rats

Cited by 4 publications

References 35 publications

Capsaicinoids-induced changes of plasma glucose, free fatty acid and glycerol concentrations in rats

Capsaicinoids-induced changes of plasma glucose, free fatty acid and glycerol concentrations in rats

Dietary zinc-deficiency and its recovery responses in rat liver cytosolic alcohol dehydrogenase activities

Different Recovery Responses from Dietary Zinc-Deficiency in the Distribution of Rat Granulocytes

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