Lowered serum total<scp>L</scp>-carnitine levels are associated with obesity at term pregnancy

Tipi-Akbas, Pinar; Ariöz, Dağıstan Tolga; Kanat-Pektaş, Mine; Köken, Tülay; Köken, Gülengül; Yılmazer, Mehmet

doi:10.3109/14767058.2013.789847

Cited by 9 publications

(6 citation statements)

References 21 publications

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“…To date, only one cross-sectional study examined the correlations between serum L-carnitine levels and MS profile in 118 healthy women with singleton term pregnancy (16). The study identified significant negative correlations between serum L-carnitine with pre-pregnancy body weight, BMI and serum TG levels (16). Due to the unusual metabolic and energy status during pregnancy, the difference is hard to explain and may not be contradictory.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies in both humans and animals also show that dietary L-carnitine could notably reduce body weight and improve serum lipid profiles (14, 15). Serum L-carnitine levels are significantly lower in obese pregnant women (16). L-carnitine can also alleviate IR in high fructose-fed rodents (17), while evidence of the same in humans is lacking.…”

Section: Introductionmentioning

confidence: 99%

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Unfavorable Associations Between Serum Trimethylamine N-Oxide and L-Carnitine Levels With Components of Metabolic Syndrome in the Newfoundland Population

et al. 2019

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Background: We aimed to study the relationships between serum Trimethylamine N-oxide (TMAO) and L-carnitine levels with metabolic syndrome profiles, including obesity, blood pressure, serum lipids, serum glucose and insulin resistance (IR)-related index in humans. Methods: Cross-sectional study was performed in 1,081 subjects from the CODING study in Newfoundland. Serum TMAO and L-carnitine levels were quantified by LC-MS/MS. Metabolic markers were measured in all subjects using fasting blood samples. Partial correlation and linear regression analysis were employed after systematically controlling the major confounding factors, such as age, gender, calorie intake and physical activity level. Results: Serum L-carnitine level was positively correlated with serum triglyceride (TG), serum insulin, IR in males with normal fasting glucose ( p < 0.05 for all) and positively correlated with only serum TG ( p < 0.05) in those with hyperglycemia. In females, significant positive correlations were identified between serum L-carnitine level with obesity, serum total cholesterol, glucose, insulin, and IR in those with normal fasting glucose level ( p < 0.05 for all), while none was found in those with hyperglycemia. Serum TMAO level was only identified to be positively correlated with serum insulin level and IR in hyperglycemic males ( p < 0.05 for all). Conclusions: Serum L-carnitine level was significantly associated with an unfavorable metabolic syndrome (MS) profile mainly in subjects with normal serum glucose level, while serum TMAO level was associated with an unfavorable MS profile in subjects with hyperglycemia. The gender difference warrants further investigations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Unfavorable Associations Between Serum Trimethylamine N-Oxide and L-Carnitine Levels With Components of Metabolic Syndrome in the Newfoundland Population

et al. 2019

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“…Acylcarnitine serum levels were reduced during pregnancy and Lcarnitine integration in pregnant women may be safe and advantageous [5]. In addition, low L-carnitine levels were recently associated with obesity at term pregnancy, representing a significant risk factor for sleep apnea and sleepiness [10]. Perhaps, an inadequate iron status may impair carnitine synthesis, which in turn provides an explanation for the low plasma carnitine concentrations observed in pregnant women [5].…”

Section: Discussionmentioning

confidence: 99%

Oral l-carnitine as treatment for narcolepsy without cataplexy during pregnancy: A case report

Romigi¹,

Liguori²,

Izzi³

et al. 2015

Journal of the Neurological Sciences

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“…This obesogenic diet is rich in simple sugars (such as fructose and sucrose) as well as long-chain saturated and trans fats. 34 This decreased -carnitine in obesity may explain the reduced fat oxidation and hence the increased body fat which is associated with the development of cardiovascular remodelling and non-alcoholic fatty liver disease. Intake of energy-dense diets in humans have been linked to the development of obesity and metabolic syndrome 1 which provides the validation of this model for anti-obesity interventions.…”

Section: Discussionmentioning

confidence: 99%

“…29 In obesity, the concentrations of L-carnitine in the body are lowered. 34 This decreased L-carnitine in obesity may explain the reduced fat oxidation and hence the increased body fat which is associated with the development of cardiovascular remodelling and non-alcoholic fatty liver disease. 35,36 L-Carnitine supplementation increased concentrations of L-carnitine in plasma as well as muscles.…”

Section: Discussionmentioning

confidence: 99%

Modulation of tissue fatty acids byl-carnitine attenuates metabolic syndrome in diet-induced obese rats

et al. 2015

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Obesity and dyslipidaemia are metabolic defects resulting from impaired lipid metabolism. These impairments are associated with the development of cardiovascular disease and non-alcoholic fatty liver disease. Correcting the defects in lipid metabolism may attenuate obesity and dyslipidaemia, and reduce cardiovascular risk and liver damage. L-Carnitine supplementation was used in this study to enhance fatty acid oxidation so as to ameliorate diet-induced disturbances in lipid metabolism. Male Wistar rats (8-9 weeks old) were fed with either corn starch or high-carbohydrate, high-fat diets for 16 weeks. Separate groups were supplemented with L-carnitine (1.2% in food) on either diet for the last 8 weeks of the protocol. High-carbohydrate, high-fat diet-fed rats showed central obesity, dyslipidaemia, hypertension, impaired glucose tolerance, hyperinsulinaemia, cardiovascular remodelling and non-alcoholic fatty liver disease. L-Carnitine supplementation attenuated these high-carbohydrate, high-fat diet-induced changes, together with modifications in lipid metabolism including the inhibition of stearoyl-CoA desaturase-1 activity, reduced storage of short-chain monounsaturated fatty acids in the tissues with decreased linoleic acid content and trans fatty acids stored in retroperitoneal fat. Thus, L-carnitine supplementation attenuated the signs of metabolic syndrome through inhibition of stearoyl-CoA desaturase-1 activity, preferential β-oxidation of some fatty acids and increased storage of saturated fatty acids and relatively inert oleic acid in the tissues.

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Lowered serum totalL-carnitine levels are associated with obesity at term pregnancy

Abstract: The crucial role of L-carnitine in pregnancy metabolism suggests that nutritional supplementation of this amino acid can be offered to women who are either overweight or obese at the beginning of the pregnancy.

Cited by 9 publications

References 21 publications

Unfavorable Associations Between Serum Trimethylamine N-Oxide and L-Carnitine Levels With Components of Metabolic Syndrome in the Newfoundland Population

Unfavorable Associations Between Serum Trimethylamine N-Oxide and L-Carnitine Levels With Components of Metabolic Syndrome in the Newfoundland Population

Oral l-carnitine as treatment for narcolepsy without cataplexy during pregnancy: A case report

Modulation of tissue fatty acids byl-carnitine attenuates metabolic syndrome in diet-induced obese rats

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