Lowered sensitivity to facial emotions in myotonic dystrophy type 1

Takeda, Akitoshi; Kobayakawa, Mutsutaka; Suzuki, Atsunobu; Tsuruya, Natsuko; Kawamura, Mitsuru

doi:10.1016/j.jns.2009.01.014

Cited by 30 publications

(32 citation statements)

References 38 publications

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“…In our previous study, we suggested that impaired facial expression recognition might be associated with limbic lesions extending from the anterior temporal areas to the orbitofrontal cortex in DM1 patients [12]. The analysis of white matter lesions in this study revealed a relatively homogeneous lesion distribution and the lesions were predominantly found in the frontal, temporal, and insular regions while the parietal and occipital subcortex regions were largely intact.…”

Section: Discussionsupporting

confidence: 48%

“…This method has 2 significant advantages: (i) it eliminates the ceiling effect and is sensitive enough to detect mild impairments and (ii) it effectively controls the differential difficulty levels across emotions and is appropriate for the examination of emotion-specific impairments. Using this method in a previously reported case study, we demonstrated that the sensitivities to anger, fear, and disgust were decreased in DM1 patients [12].…”

Section: Discussionmentioning

confidence: 80%

“…The selected patients did not exhibit apathy, fatigue, or somnolence, and had no history of mental disease, traumatic brain injury, or alcoholism. Two of these cases have been previously reported [12].…”

Section: Participantsmentioning

confidence: 91%

“…Winblad et al reported that the ability to recognize facial expressions was impaired in a large number of DM1 patients [11]; however, they did not investigate the neural mechanisms underlying such impairment. Moreover, in our previous study, we used a method to quantitatively measure the sensitivity to facial expressions and observed that the sensitivity to negative facial expressions was lowered in 2 DM1 patients [12]. We previously conducted a case study of 4 DM1 patients and observed that DM1 patients with lesions in the anterior temporal subcortex exhibited decreased sensitivity to facial emotions [13].…”

Section: Introductionmentioning

confidence: 99%

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Facial emotion recognition and cerebral white matter lesions in myotonic dystrophy type 1

Kobayakawa

Tsuruya

Takeda

et al. 2010

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 80%

Section: Participantsmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Facial emotion recognition and cerebral white matter lesions in myotonic dystrophy type 1

Kobayakawa

Tsuruya

Takeda

et al. 2010

Journal of the Neurological Sciences

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“…lobe specific) in cerebral perfusion in DM1 cases compared to unaffected controls (table 3). 16,53,60,84,85 In fMRI studies, an altered activation pattern in bilateral motor regions was demonstrated in DM1 patients during a motor task and in the presence of clinical myotonia. 13,86 Abnormal resting-state functional connectivity in defaultmode and 'theory-of-mind' networks was also noted in relation to personality traits and social cognition in DM1 (table 3).…”

Section: Structural Imaging Studiesmentioning

confidence: 99%

Brain imaging in myotonic dystrophy type 1

Okkersen

Monckton

et al. 2017

Neurology

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Objective:To systematically review brain imaging studies in myotonic dystrophy type 1 (DM1).Methods:We searched Embase (index period 1974–2016) and MEDLINE (index period 1946–2016) for studies in patients with DM1 using MRI, magnetic resonance spectroscopy (MRS), functional MRI (fMRI), CT, ultrasound, PET, or SPECT. From 81 studies, we extracted clinical characteristics, primary outcomes, clinical-genetic correlations, and information on potential risk of bias. Results were summarized and pooled prevalence of imaging abnormalities was calculated, where possible.Results:In DM1, various imaging changes are widely dispersed throughout the brain, with apparently little anatomical specificity. We found general atrophy and widespread gray matter volume reductions in all 4 cortical lobes, the basal ganglia, and cerebellum. The pooled prevalence of white matter hyperintensities is 70% (95% CI 64–77), compared with 6% (95% CI 3–12) in unaffected controls. DTI shows increased mean diffusivity in all 4 lobes and reduced fractional anisotropy in virtually all major association, projection, and commissural white matter tracts. Functional studies demonstrate reduced glucose uptake and cerebral perfusion in frontal, parietal, and temporal lobes, and abnormal fMRI connectivity patterns that correlate with personality traits. There is significant between-study heterogeneity in terms of imaging methods, which together with the established clinical variability of DM1 may explain divergent results. Longitudinal studies are remarkably scarce.Conclusions:DM1 brains show widespread white and gray matter involvement throughout the brain, which is supported by abnormal resting-state network, PET/SPECT, and MRS parameters. Longitudinal studies evaluating spatiotemporal imaging changes are essential.

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Investigating the impact of disposable surgical face‐masks on face identity and emotion recognition in adults with autism spectrum disorder

et al. 2023

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With the outburst of the COVID‐19 pandemic, disposable surgical face‐masks (DSFMs) have been widely adopted as a preventive measure. DSFMs hide the bottom half of the face, thus making identity and emotion recognition very challenging, both in typical and atypical populations. Individuals with autism spectrum disorder (ASD) are often characterized by face processing deficits; thus, DSFMs could pose even a greater challenge for this population compared to typically development (TD) individuals. In this study, 48 ASDs of level 1 and 110 TDs underwent two tasks: (i) the Old‐new face memory task, which assesses whether DSFMs affect face learning and recognition, and (ii) the Facial affect task, which explores DSFMs' effect on emotion recognition. Results from the former show that, when faces were learned without DSFMs, identity recognition of masked faces decreased for both ASDs and TDs. In contrast, when faces were first learned with DSFMs, TDs but not ASDs benefited from a “context congruence” effect, that is, faces wearing DSFMs were better recognized if learned wearing DSFMs. In addition, results from the Facial affect task show that DSFMs negatively impacted specific emotion recognition in both TDs and ASDs, although differentially between the two groups. DSFMs negatively affected disgust, happiness and sadness recognition in TDs; in contrast, ASDs performance decreased for every emotion except anger. Overall, our study demonstrates a general, although different, disruptive effect on identity and emotion recognition both in ASD and TD population.

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Lowered sensitivity to facial emotions in myotonic dystrophy type 1

Cited by 30 publications

References 38 publications

Facial emotion recognition and cerebral white matter lesions in myotonic dystrophy type 1

Facial emotion recognition and cerebral white matter lesions in myotonic dystrophy type 1

Brain imaging in myotonic dystrophy type 1

Investigating the impact of disposable surgical face‐masks on face identity and emotion recognition in adults with autism spectrum disorder

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