Lowered Postoperative Ldl-C/Hdl-C Ratio Reduces Later Cardiovascular Events after Abdominal Aortic Aneurysm Surgery

Kanaoka, Tsuyoshi; Takahashi, Junichiro; Wakamatsu, Yutaka; Ishii, Kota; Gohda, T; Sasaki, Shigeyuki; Matsui, Yoshiro

doi:10.3400/avd.oa.11.00068

Cited by 8 publications

(7 citation statements)

References 25 publications

(28 reference statements)

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“…Furthermore, for F2 males, some blood phenotypic alterations including ACTH, CORT, glucose, TCH and LDL-C have parental differences. Furthermore, LDL-C/HDL-C ratio was increased after stress only in F2 paternal males, which suggests a high risk for cardiovascular diseases, and is consistent with the previous reports (Kanaoka et al, 2012;Lejskova et al, 2012). On the other hand, some gender differences were observed.…”

Section: Caffeine-induced the Neuroendocrine Metabolic Programming Alsupporting

confidence: 92%

Prenatal caffeine ingestion induces transgenerational neuroendocrine metabolic programming alteration in second generation rats

Luo¹,

Deng²,

Liu³

et al. 2014

Toxicology and Applied Pharmacology

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Section: Caffeine-induced the Neuroendocrine Metabolic Programming Alsupporting

confidence: 92%

Prenatal caffeine ingestion induces transgenerational neuroendocrine metabolic programming alteration in second generation rats

Luo¹,

Deng²,

Liu³

et al. 2014

Toxicology and Applied Pharmacology

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“…1B). We further examined the phenotype of the serum cholesterol level and calculated the TCH/HDL-C and LDL-C/ HDL-C ratios, which are risk factors of cardiovascular disease (32,33). The results showed that serum TCH and LDL-C levels in PCE female adult offspring were increased significantly compared with those of controls (Fig.…”

Section: Resultsmentioning

confidence: 96%

Intrauterine programming mechanism for hypercholesterolemia in prenatal caffeine‐exposed female adult rat offspring

Luo

et al. 2018

FASEB j.

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Clinical and animal studies have indicated that hypercholesterolemia and its associated diseases have intrauterine developmental origins. Our previous studies showed that prenatal caffeine exposure (PCE) led to fetal overexposure to maternal glucocorticoids (GCs) and increased serum total cholesterol levels in adult rat offspring. This study further confirms the intrauterine programming of PCE-induced hypercholesterolemia in female adult rat offspring. Pregnant Wistar rats were intragastrically administered caffeine (30, 60, and 120 mg/kg/d) from gestational day (GD)9 to 20. Female rat offspring were euthanized at GD20 and postnatal wk 12; several adult rat offspring were additionally subjected to ice-water swimming stimulation to induce chronic stress prior to death. The effects of GCs on cholesterol metabolism and epigenetic regulation were verified using the L02 cell line. The results showed that PCE induced hypercholesterolemia in adult offspring, which manifested as significantly higher levels of serum total cholesterol and LDL cholesterol (LDL-C) as well as higher ratios of LDL-C/HDL cholesterol. We further found that the cholesterol levels were increased in fetal livers but were decreased in fetal blood, accompanied by increased maternal blood cholesterol levels and reduced placental cholesterol transport. Furthermore, analysis of PCE offspring in the uterus and in a postnatal basal/chronic stress state and the results of in vitro experiments showed that hepatic cholesterol metabolism underwent GC-dependent changes and was associated with cholesterol synthase via abnormalities in 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) histone acetylation. We concluded that, to compensate for intrauterine placentally derived decreases in fetal blood cholesterol levels, high intrauterine GC levels activated fetal hepatic CCAAT enhancer binding protein α signaling and down-regulated Sirtuin1 expression, which mediated the high levels of histone acetylation ( via H3K9ac and H3K14ac) and expression of HMGCR. This GC-dependent cholesterol metabolism programming effect was sustained through adulthood, leading to the occurrence of hypercholesterolemia.-Xu, D., Luo, H. W., Hu, W., Hu, S. W., Yuan, C., Wang, G. H., Zhang, L., Yu, H., Magdalou, J., Chen, L. B., Wang, H. Intrauterine programming mechanism for hypercholesterolemia in prenatal caffeine-exposed female adult rat offspring.

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“…Surgical repair is currently the only option for preventing AAA rupture 4 and, notably, endovascular treatment improves the surgical outcome in AAA treatment 5,6 . Recently, we found that metabolic abnormalities, especially serum dyslipidemia, are associated with AAA progression and mortality 7,8 . Proprotein convertase subtilisin/kexin type 9 PCSK9 is a secreted enzyme that increases the degradation of surface low-density lipoprotein receptors LDLRs , decreasing the removal of LDL-bound cholesterol from the blood.…”

Section: Introductionmentioning

confidence: 99%

Proprotein Convertase Subtilisin/Kexin Type 9 Is Associated with Degenerating Adipocytes in Abdominal Aortic Aneurysm

et al. 2018

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Abdominal aortic aneurysm (AAA) is a common disease among the elderly. Recently, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have been indicated as useful therapeutic tools for the treatment of cardiovascular diseases. The aim of this study was to elucidate the role of PCSK9 in the pathogenesis of AAA. We used fluorescence immunohistochemistry to assess the expression of PCSK9 in aortic tissues resected from 24 patients with AAA. Histological examination showed that PCSK9 expression in the adventitia region of the aneurysms was decreased in AAA samples. In the same region, the expression of CD36 increased. We hypothesized that CD36 expression might upregulate the transport of fatty acids into cells such as the adipocytes, and subsequently cause degradation of the adventitia in the aortic wall, contributing to AAA development.

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Lowered Postoperative Ldl-C/Hdl-C Ratio Reduces Later Cardiovascular Events after Abdominal Aortic Aneurysm Surgery

Cited by 8 publications

References 25 publications

Prenatal caffeine ingestion induces transgenerational neuroendocrine metabolic programming alteration in second generation rats

Prenatal caffeine ingestion induces transgenerational neuroendocrine metabolic programming alteration in second generation rats

Intrauterine programming mechanism for hypercholesterolemia in prenatal caffeine‐exposed female adult rat offspring

Proprotein Convertase Subtilisin/Kexin Type 9 Is Associated with Degenerating Adipocytes in Abdominal Aortic Aneurysm

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