Lowered plasma paraoxonase (PON)1 activity is a trait marker of major depression and PON1 Q192R gene polymorphism–smoking interactions differentially predict the odds of major depression and bipolar disorder

Bortolasci, Chiara C.; Vargas, Heber Odebrecht; Souza-Nogueira, André; Barbosa, Décio Sabbatini; Moreira, Estefânia Gastaldello; Nunes, Sandra Odebrecht Vargas; Berk, Michael; Dodd, Seetal; Maes, Michaël

doi:10.1016/j.jad.2014.02.018

Cited by 70 publications

(57 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Psikoz spektrum bozukluklarda ve duygudurum bozukluklarında oksidan bileşiklerin üretimi artmaktadır (Joshi ve Pratico 2014) ve dolayısıyla lipit peroksidasyonu sağlıklı bireylere göre daha fazla oluşmakta ve yeterli derecede elimine edilememektedir (Bortolasci ve ark. 2014a, Bortolasci ve ark.…”

Section: Introductionunclassified

Phenotypic Variants of Paraoxonase Q192R in Bipolar Disorder, Depression and Schizophrenia

Atagün¹,

Tunç²,

Alışık³

et al. 2017

Turkish Journal of Psychiatry

View full text Add to dashboard Cite

ÖZETAmaç: Paraoksonaz 1 (PON1) enzim aktivitesi PON1 Q912R genotipine göre belirgin farklılık göstermektedir. Perokside lipitleri arjinin (R) genotipi, glutamin (Q) genotipine göre daha hızlı ve fazla miktarda hidrolizlemektedir. Q genotipi nörodejenerasyon, kardiyovasküler ve malignensi risklerine daha büyük yatkınlık oluşturmaktadır. Serum stimüle paraoksonaz/aril esteraz oranı PON1 Q192R genotipine uygun biçimde dağılım gösterdiğinden fenotip olarak kabul edilmektedir. Bu çalışmada bipolar bozukluk, depresyon ve şizofreni grupları arasında serum PON1 aktivitesi ve Q192R fenotip dağılımları açısından farklılık olup olmadığının değerlendirilmesi amaçlanmıştır.Yöntem: Çalışmamıza 50 bipolar bozukluk, 43 major depreson, 37 şizofreni hastası ve 43 sağlıklı gönüllü dahil edildi. Serum PON1, stimüle paraoksonaz (sPON), aril esteraz (ARES) düzeyleri otomatik analizörle ölçüldü. sPON/ARES oranında görülen kümelenmeler frekans hesaplamalarına göre QQ, QR ve RR fenotip grupları elde edildi. Bulgular: Bipolar bozukluk, depresyon, şizofreni ve kontrol grupların-da fenotip dağılımları bakımından istatistiksel olarak anlamlı derecede farklı bulundu (Fisher'in Kesin Katsayısı=18,96, p=0,003). Bipolar bozukluk grubunda RR, depresyon ve şizofreni gruplarında QQ varyantlarının frekansı yüksekti. Serum PON1 aktivitesiyle bipolar bozuklukta geçirilmiş dönem sayısı arasında ve şizofreni grubunda SANS ve SAPS puanları arasında bağıntı görüldü.Sonuç: Bipolar bozukluk, şizofreni ve yineleyici depresyon arasında PON1 aktivitesi ve fenotip varyasyonu açısından fark olması lipit peroksidasyonu ve nörodejeneratif süreçlere yatkınlık açısından bu tanı grupları arasında fark olduğunu göstermektedir. Uzunlamasına izlem çalışmaları Q192R varyantları arasında klinik seyir ve nöropatolojik farkların tespit edilmesini sağlayabilir.Anahtar Sözcükler: Bipolar bozukluk, depresyon, şizofreni, paraoksonaz, fenotip SUMMARY Phenotypic Variants of Paraoxonase Q192R in Bipolar Disorder, Depression and SchizophreniaObjective: Activity of the paraoxonase 1 (PON1) enzyme varies prominently according to the PON1 Q192R genotype. The arginine (R) genotype hydrolyzes peroxided lipids more quickly and efficiently than the glutamine (Q) genotype. The Q phenotype suggests greater liability to neurodegenerative processes, cardiovascular and malignancy risks than the R phenotype. Stimulated PON/ARES ratio is associated with the PON1 Q192R polymorphism. This study aimes to assess the Q192R phenotype in schizophrenia, bipolar disorder and depression. Method:Patients with schizophrenia (37), bipolar disorder (n=50), depression (n=43) and healthy volunteers (n=43) were enrolled. Serum PON1, stimulated paraoxonase (sPON) and aryl esterase (ARES) levels were assessed with an automatic analyzer. Clusters of sPON/ARES ratio were detected with frequency analysis in PON1. QQ, QR and RR variant groups.Results: There were significant differences between the bipolar disorder, depression, schizophrenia and healthy volunteer groups in terms of phenotype frequencies ...

show abstract

Section: Introductionunclassified

Phenotypic Variants of Paraoxonase Q192R in Bipolar Disorder, Depression and Schizophrenia

Atagün¹,

Tunç²,

Alışık³

et al. 2017

Turkish Journal of Psychiatry

View full text Add to dashboard Cite

show abstract

“…Two studies investigated PON1 activity in bipolar patients. The first one presented normal PON1 activity but the other showed decreased PON1 activity in bipolar patients 13,20 . In a study consisting of both depressed and bipolar patients; lowered PON1 activity was found to be associated with comorbid mood disorders and tobacco use disorder 14 .…”

Section: Introductionmentioning

confidence: 91%

“…The odds of bipolar disorder were increased by the QQ genotype of Q192R in smokers 13 . In a genome-wide association study, no associations between bipolar disorder and the Q192R polymorphism or any other polymorphism in the PON1 gene was detected.…”

Section: Introductionmentioning

confidence: 94%

“…Also, no significant association was found between PON1Q192R polymorphism and depression in populationbased studies 16 . While some studies found no differences in terms of PON1 activity between patients with depression and controls 17 ; others demonstrated a diminished PON1 activity 13,18,19 . Furthermore, it was indicated that antidepressant treatment increased the lowered paraoxonase/arylesterase levels 19 .…”

Section: Introductionmentioning

confidence: 94%

“…Another study demonstrated that PON1 Q192R-smoking interaction predicted the odds of depression 13 . Contrarily, no associations were detected between mood disorders and any of the Q192R genotypes 14 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder

Yıldız¹,

Celikel²,

Ateş³

et al. 2017

JMOOD

View full text Add to dashboard Cite

Background: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depression and bipolar disorder. Objective: The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depression and bipolar affective disorder. Methods: PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patients with major depression, and 100 patients with bipolar affective disorder and 96 healthy controls. Polymorphisms were analyzed by using polymerase chain reaction. Results: Our findings reported no association between Q192R and L55M polymorphisms of PON1 and major depression and bipolar disorder. Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolar patients. Discussion: Evaluating the different stages of patients with affective disorders and and investigating the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders.

show abstract

Study on exosomes for identifying bipolar disorder in early stage: A cross‐sectional and validation study protocol

Wu,

Li,

et al. 2024

Brain and Behavior

View full text Add to dashboard Cite

BackgroundThe difficulty is remained to accurately distinguish bipolar disorder (BD) from major depressive disorder (MDD) in early stage, with a delayed diagnosis for 5–10 years. BD patients are often treated with antidepressants systematically due to being diagnosed with MDD, affecting the disease course and clinical outcomes. The current study aims to explore the role of plasma exosomes as biomarker to distinguish BD from MDD in early stage.MethodsTwo stages are included. The first stage is a cross‐sectional study, comparing the concentrations of plasma exosome microRNA and related proteins among BD group, MDD group, and healthy controls (HC) group (n = 40 respectively), to identify target biomarkers preliminarily. The “Latent Class Analysis” and “Receiver Operating Characteristic” analysis will be performed to determine the optimal concentration range for each biomarker. The second stage is to validate target markers in subjects, coming from an ongoing study focusing on patients with a first depressive episode. All target biomarkers will be test in plasma samples reserved at the initial stage to detect whether the diagnosis indicated by biomarker level is consistent with the diagnosis by DSM‐5. Furthermore, the correlation between specific biomarkers and the manic episode, suicidal ideation, and adverse reactions will also be observed.DiscussionExosome‐derived microRNA and related proteins have potential in serving as a good medium for exploring mental disorders because it can pass through the blood‐brain barrier bidirectionally and convey a large amount of information stably. Improving the early diagnosis of BD would help implement appropriate intervention strategy as early as possible and significantly reduce the burden of disease.

show abstract

Lowered plasma paraoxonase (PON)1 activity is a trait marker of major depression and PON1 Q192R gene polymorphism–smoking interactions differentially predict the odds of major depression and bipolar disorder

Cited by 70 publications

References 57 publications

Phenotypic Variants of Paraoxonase Q192R in Bipolar Disorder, Depression and Schizophrenia

Phenotypic Variants of Paraoxonase Q192R in Bipolar Disorder, Depression and Schizophrenia

Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder

Study on exosomes for identifying bipolar disorder in early stage: A cross‐sectional and validation study protocol

Contact Info

Product

Resources

About