Lower urinary tract symptoms (LUTS) after renal transplant in non‐urologic anuric patients

Castagnetti, Marco; Zhapa, Evisa; Berrettini, Alfredo; Ghirardo, G; Murer, Luisa; Zanon, Giovanni Franco; Rigamonti, Waifro

doi:10.1111/j.1399-3046.2010.01390.x

Cited by 8 publications

(5 citation statements)

References 19 publications

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“…1112 One of the reasons for the high number of patients with urinary incontinence might be the relatively high proportion of children with daytime and nocturnal polyuria after transplantation as seen in our study as well as other studies. 20 Fluid intake in mL/ kg/24 hours was positively correlated with polyuria (24 hours) (R = 0.582, P = .00), but not for nocturnal polyuria (R = −0.03, P = .843). Especially in patients 10 years of age and younger, a remarkably high fluid intake and subsequent polyuria were documented.…”

Section: Discussionmentioning

confidence: 90%

Outcome of a thorough screening of lower urinary tract function in all pediatric kidney recipients

Wall

Oomen

Glaap‐Roeven

et al. 2020

Pediatric Transplantation

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LUTD is one of the possible factors influencing pediatric kidney graft outcomes. This study evaluates the results of a thorough assessment of voiding behavior in pediatric transplants. Data of patients with kidney disease of nephrological origin are compared to those with urological origin. A single-center analysis of pediatric kidney transplants performed from 2005 to the present was executed. Donor and recipient characteristics as well as voiding and drinking habits were documented using FVCs and uroflowmetry with PVR measurements. LUTD was defined by a mean MVV >150% or <65% of the EBC for age, abnormal uroflowmetry, PVR repeatedly >15% of EBC or >20 mL, abnormal voiding patterns or behavior, and presence of LUT symptoms. LUTD was diagnosed in 71% of the 56 screened children and more present in urological origin of kidney disease (100%) compared to nephrological origin (61%, P = .005). Individual presence of LUT symptoms, abnormal voiding behavior, FVC parameters, UTIs, and uroflowmetry/PVR parameters were not different between the two groups. Polyuria after transplantation was seen in 63% of patients, mainly in the first post-transplant years and recipients aged <10 years. Time after transplantation was a significant independent predictive factor for the presence of LUTD. LUTD is common in all pediatric kidney recipients and underestimated in those with a nephrological origin of disease.Active screening, monitoring and a care attention plan prior to transplantation and during follow-up, is advocated to optimize outcomes for all patients.

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Section: Discussionmentioning

confidence: 90%

Outcome of a thorough screening of lower urinary tract function in all pediatric kidney recipients

Wall

Oomen

Glaap‐Roeven

et al. 2020

Pediatric Transplantation

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“…They propose to postpone surgical treatment until after renal transplantation ( 7 , 12 ). Castagnetti found no difference in LUTS in anuric children after RTx compared to recipients with diuria before RTx ( 17 ). By contrast, Reinberg, in 1992, described complications in TURP immediately following RTx in 25% of the patients, including one death ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Management of Lower Urinary Tract Symptoms Related to Benign Prostatic Obstruction in a Contemporary Series of Renal Transplant Recipients

et al. 2016

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BackgroundThe kidney is the most frequently transplanted human organ worldwide. In patients with end-stage renal failure, renal transplantation improves both quality of life and life expectancy. The current literature indicates that the numbers of renal recipients over 60 years of age has increased in recent years.ObjectivesTo evaluate the prevalence and management of lower urinary tract symptoms (LUTS) related to benign prostatic obstruction (BPO) in a contemporary series of male renal transplant (RTx) recipients.Materials and MethodsWe retrospectively evaluated 150 consecutive transplant recipients at the University of Jena 12 months postoperatively for the presence and treatment of LUTS related to BPO.ResultsThe mean age of the patients was 59 years (range 27 - 82 years). By 12 months postoperatively, 91% (n = 137/150) were off dialysis with a functioning kidney graft. Two patients died during follow up. Six patients had undergone treatment for prostate cancer prior to RTx. Of the remaining 131 patients, 47% (n = 62/131) were considered as patients with BPO 12 months after RTx. Six percent (n = 8/131) of the patients experienced urinary retention due to BPO and 6% (n = 8/131) had a transurethral resection of the prostate (TURP) during the first year after RTx. No major complications were observed in those patients. A significant increase was noted in the use of α-blocker therapy after RTx (P = 0.004).ConclusionsWe observed a high prevalence of LUTS related to BPO in our cohort of patients. Due to the increasing age of transplant recipients, more attention should be paid to the evaluation and treatment of BPO prior to RTx.

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“…By consequence, there is little consistency on the prevalence of LUTD (91,92). Although LUTD was particularly thought to be a problem in urological patients, LUTD was found to be fairly common in all kidney recipients despite underlying cause for ESKD (93)(94)(95)(96).…”

Section: Urological Work-up and Follow-upmentioning

confidence: 99%

“…These low-capacity bladders cannot adjust to a sudden increase of urine volume, e.g., after transplantation. This might result in high intra-vesical pressures that lead to LUTD and a subsequent deteriorating effect on graft function (93,95,96).…”

Section: Urological Work-up and Follow-upmentioning

confidence: 99%

Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades

et al. 2022

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Worldwide, over 1,300 pediatric kidney transplantations are performed every year. Since the first transplantation in 1959, healthcare has evolved dramatically. Pre-emptive transplantations with grafts from living donors have become more common. Despite a subsequent improvement in graft survival, there are still challenges to face. This study attempts to summarize how our understanding of pediatric kidney transplantation has developed and improved since its beginnings, whilst also highlighting those areas where future research should concentrate in order to help resolve as yet unanswered questions. Existing literature was compared to our own data of 411 single-center pediatric kidney transplantations between 1968 and 2020, in order to find discrepancies and allow identification of future challenges. Important issues for future care are innovations in immunosuppressive medication, improving medication adherence, careful donor selection with regard to characteristics of both donor and recipient, improvement of surgical techniques and increased attention for lower urinary tract dysfunction and voiding behavior in all patients.

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Lower urinary tract symptoms (LUTS) after renal transplant in non‐urologic anuric patients

Cited by 8 publications

References 19 publications

Outcome of a thorough screening of lower urinary tract function in all pediatric kidney recipients

Outcome of a thorough screening of lower urinary tract function in all pediatric kidney recipients

Prevalence and Management of Lower Urinary Tract Symptoms Related to Benign Prostatic Obstruction in a Contemporary Series of Renal Transplant Recipients

Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades

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