Lower Urinary Tract Symptoms in Elderly Population With Multiple Sclerosis

Chesnel, C.; Charlanes, A.; Hentzen, Claire; Turmel, Nicolas; Breton, F. Le; Ismaël, Samer Sheikh; Amarenco, G.

doi:10.5213/inj.1835054.527

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…33,34 These findings suggest that aging may exacerbate urinary disorders in MS patients through potentiating pathophysiological factors. 35 According to the current study, LUTS was found to be more common in patients with academic degrees than in those without an academic degree or who were illiterate; however, the difference did not reach statistical significance. In line with our study, an Austrian cross-sectional study found no significant correlation between LUTS and the level of education in men.…”

Section: Discussioncontrasting

confidence: 65%

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Multiple sclerosis and lower urinary tract symptoms: A survey of prevalence, characteristic and urological evaluations

et al. 2023

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Objective: Most multiple sclerosis patients have urological complications such as lower urinary tract symptoms. This study was conducted to evaluate the prevalence of these symptoms and whether they result in a urological evaluation. Methods: A cross-sectional study of 517 multiple sclerosis patients at Tehran’s referral multiple sclerosis center and neurology clinics between 2018 and 2022 was performed. Data were collected through interviews after patients completed informed consent forms. Urological examinations, including urine analysis and ultrasonography, were evaluated as final assessments. The data were analyzed using descriptive and inferential statistical tests in Statistical Package for Social Science. Results: Among all participants, the prevalence of lower urinary tract symptoms was 73% ( n = 384), with urgency (44.8% n = 232) being the most common symptom. The prevalence of intermittency was significantly higher among women ( p = 0.004). There was no gender-significant difference in terms of the prevalence of other symptoms ( p > 0.050). Lower urinary tract symptoms were significantly correlated with age, clinical course, disease duration, and disability ( p < 0.001). Additionally, 37.3% and 18.7% of patients with lower urinary tract symptoms, as well as 17.9% and 37.5% of patients with multiple sclerosis attacks, respectively, had undergone urine analysis and ultrasonography. Conclusion: Multiple sclerosis patients rarely undergo urological evaluations during the course of their disease. Proper assessment is essential as these symptoms are among the most detrimental manifestations of this disease.

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Section: Discussioncontrasting

confidence: 65%

“… 33 , 34 These findings suggest that aging may exacerbate urinary disorders in MS patients through potentiating pathophysiological factors. 35 …”

Section: Discussionmentioning

confidence: 99%

Multiple sclerosis and lower urinary tract symptoms: A survey of prevalence, characteristic and urological evaluations

et al. 2023

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“…Yet, Koldewijn1995 found that age is not an influencing factor on clinical or urodynamic profile [53]. It could be thinkable that age and MS, by means of potentiation of pathophysiological factors, may increase rate and /or severity of urinary problems in this specific population [54].…”

Section: Discussionmentioning

confidence: 99%

Quality of life among patients with multiple sclerosis and voiding dysfunction: a cross-sectional study

et al. 2020

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Background: Evaluating the usefulness of treatment requires a direct measurement of the health-related quality of life (QOL). Therefore, this study was carried out aiming to determine the QOL of patients with MS and voiding dysfunction. Methods: This cross-sectional study was carried out using multi-stage random cluster sampling method on 602 patients with MS in Isfahan, Iran. All data were collected through interviews using standard questionnaires including International Prostate Symptom Score (IPSS), and the Multiple Sclerosis Quality of Life-54 (MSQOL-54). Data were analyzed using descriptive and inferential statistical tests. Results: The prevalence rate of mixed, irritative, and obstructive urinary symptoms was 52.2, 25.5, and 6.5%, respectively. The mixed symptom had the highest prevalence among men and women with rates of 56.5 and 51.1%, respectively. The prevalence of irritative and obstructive symptoms was, respectively, higher and statistically significant among women alone and men alone (P < 0.05). The prevalence of irritative symptoms was higher among patients with MS, EDSS score ≤ 3, disease duration of less than 5 years, and with clinically isolated syndrome. In addition, the prevalence of mixed symptoms was higher among patients with MS of over 30 years of age with a Pre-high school degree, severe disability, disease duration of over 10 years, and progressive MS; the difference was statistically significant (P < 0.05). There was a difference in the combined dimensions of physical and mental health of QOL between the two groups with and without urinary symptoms (P < 0.05). Logistic regression analysis revealed that there was a higher probability of a urinary problems among patients with MS and high age [3.273 (1.083-9.860); P = 0.035]. Conclusions: Mixed urinary symptoms are highly prevalent among MS patients and affect QOL dimensions. In order to improve QOL, more attention and focus should be paid to urinary problems in MS patients.

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“…Whilst numerous questionnaires on bladder symptoms are available, the USP was chosen as it is a validated questionnaire that incorporates different domains of LUT symptoms and better describes the frequently mixed symptoms experienced by patients with MS. Although not specifically validated in neurological patients, it has been recommended as a screening tool for LUT symptoms in MS [13] and used as an outcome measure in previous studies of patients with MS [14][15][16] and other neurological conditions [17,18]. A ratio of the USP LS/total scores was calculated to account for the degree of voiding LUT symptoms compared to a patient's overall profile of LUT symptoms.…”

Section: Discussionmentioning

confidence: 99%

Use of a symptom-based questionnaire to screen for the presence of significant voiding dysfunction in patients with multiple sclerosis and lower urinary tract symptoms: a pilot study

Panicker

Haslam

et al. 2020

J Neurol

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Introduction Lower urinary tract dysfunction is common in people with multiple sclerosis, leading to overactive bladder symptoms, voiding difficulties or a combination. First-line medications for overactive bladder symptoms are effective. Current guidelines recommend measuring post-void residual volume (PVR) before commencing these treatments, as they can potentially exacerbate voiding difficulties in those with significant underlying voiding dysfunction (pre-treatment PVR > 100 ml). However, facilities to do so are not readily available to all clinicians, potentially delaying effective therapy. Aims To conduct a pilot study investigating the association between lower urinary tract symptoms and PVR volume in people with multiple sclerosis using a validated questionnaire and to determine if questionnaire scores can be used to exclude a significantly elevated (> 100 ml) PVR volume. Methods Patients with multiple sclerosis referred to a tertiary hospital uro-neurology service completed the Urinary Symptom Profile questionnaire and underwent PVR measurement by bladder ultrasound. A ratio of the questionnaire low stream score/total score was calculated to standardise the relative degree of voiding symptoms compared to overall lower urinary tract symptoms. Results Of 40 patients (29 females, mean age 50 years), 30% had an elevated PVR volume. PVR volume was correlated with low stream score and ratio of low stream/total score. A cutoff of > 0.15 for low stream/total score ratio had 92% sensitivity and 71% specificity in predicting an elevated PVR volume. Conclusion A symptom-based questionnaire maybe a useful screening tool to distinguish patients in whom PVR measurement is required from those who could safely start on treatment for overactive bladder symptoms.

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Lower Urinary Tract Symptoms in Elderly Population With Multiple Sclerosis

Cited by 5 publications

References 26 publications

Multiple sclerosis and lower urinary tract symptoms: A survey of prevalence, characteristic and urological evaluations

Multiple sclerosis and lower urinary tract symptoms: A survey of prevalence, characteristic and urological evaluations

Quality of life among patients with multiple sclerosis and voiding dysfunction: a cross-sectional study

Use of a symptom-based questionnaire to screen for the presence of significant voiding dysfunction in patients with multiple sclerosis and lower urinary tract symptoms: a pilot study

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