Lower urinary tract symptoms are associated with clinically relevant depression, anxiety, and stress symptoms

Vartolomei, Liliana; Cotruș, Andrei; Tătaru, Sabin Octavian; Vartolomei, Mihai Dorin; Man, Adrian; Ferro, Matteo; Stanciu, Camelia; Sin, Anca; Shariat, Shahrokh F.

doi:10.1080/13685538.2022.2040981

Cited by 11 publications

(7 citation statements)

References 19 publications

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“…They also suggest that comorbid conditions like type 2 diabetes could be potential targets for prevention, presenting an opportunity for intervention [ 57 , 58 , 59 , 60 ]. Identifying LUTS early on is indeed crucial to prevent potential complications that can impact general health, psychological well-being, depression, stress levels, and even sexual satisfaction and desire [ 7 , 61 , 62 , 63 ]. Within our population, a quarter of the participants experienced a decrease in their quality of life due to LUTS.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Lower Urinary Tract Symptoms in Males and Urinary Incontinence in Females in Primary Health Care in Greece

Gkatzoudi,

Bouloukaki,

Mamoulakis

et al. 2024

Medicina

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Background and Objectives: The significant prevalence of Lower Urinary Tract Symptoms (LUTS), erectile dysfunction (ED), and associated adverse effects calls for increased attention in primary care settings. In Greece, there is a lack of sufficient data for LUTS and ED screening in primary care. Therefore, the aim of our study was to estimate the prevalence of LUTS and ED, identify associated risk factors, and evaluate their impact on quality of life among adult primary healthcare users aged 40 years and older in Crete, Greece. Materials and Methods: A cross-sectional study was conducted to explore the prevalence of LUTS and ED in 1746 primary health care users visiting rural primary health care practices in Crete, Greece. Participants underwent a comprehensive evaluation including demographic parameters, screening for LUTS utilizing the validated International Prostate Symptoms Score (IPSS) questionnaire and for ED using the International Index of Erectile Function (IIEF-5), in males, and for urinary incontinence in women with the International Consultation on Incontinence Questionnaire–Urinary Incontinence Short Form (ICIQ-UI SF). Participants with a prior diagnosis of LUTS or ED were excluded (n = 183). Results: Out of 536 participants finally included (n = 1746 screened), 32% of males and 36% of females exhibited moderate to severe LUTS. Following adjustments, we identified advanced age, retirement, and the presence of diabetes type 2 as factors associated with the occurrence of LUTS in men. Patients with LUTS also had a substantially increased likelihood of experiencing ED. Moreover, it was observed that women with hypertension or diabetes type 2 and lower education levels face an increased likelihood of developing LUTS, which adversely affects their quality of life. Conclusions: In conclusion, the findings of this study reveal a high occurrence of LUTS and ED in adults aged 40 years and older who utilize primary healthcare services, with a negative impact on their quality of life.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Lower Urinary Tract Symptoms in Males and Urinary Incontinence in Females in Primary Health Care in Greece

Gkatzoudi,

Bouloukaki,

Mamoulakis

et al. 2024

Medicina

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“…Pro-inflammatory cytokines alter the regulation of fluid overload pathways in the brain and spinal cord. These cytokines can also disrupt the bladder's function by directly promoting detrusor hypertrophy and afferent nerve hypersensitivity and consequently cause LUTS [25][26][27]. One-fourth of males seeking a urologic consultation exhibit concurrent depression, anxiety, or stress symptoms [26].…”

Section: Discussionmentioning

confidence: 99%

“…These cytokines can also disrupt the bladder's function by directly promoting detrusor hypertrophy and afferent nerve hypersensitivity and consequently cause LUTS [25][26][27]. One-fourth of males seeking a urologic consultation exhibit concurrent depression, anxiety, or stress symptoms [26]. In our study, the urinary symptoms may have been exacerbated by the fear of having prostate cancer prior to the biopsy; However, since this anxiety has been alleviated for most patients whose test results were negative, the urinary symptoms may have been reduced as a result.…”

Section: Discussionmentioning

confidence: 99%

The effect of transrectal ultrasound-guided prostate biopsy on erectile function and lower urinary tract symptoms: a prospective study

et al. 2023

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Background Prostate biopsy (PB) is the gold standard for verifying the diagnosis of prostate cancer in men with clinical symptoms. Transrectal ultrasound (TRUS)-guided PB is the most common method for diagnosis; however, it has a few adverse effects. Mild consequences like bleeding and pain are prevalent but temporary. Since the relationship between erectile dysfunction and lower urinary tract symptoms (LUTS) and TRUS-guided PB is inconsistent in the literature, we aimed to conduct a study on these two consequences on males within 1 month following TRUS-guided PB. Methods Patients with a PSA ≥ 4 ml/ng who were determined to undergoTRUS-guided PB were enrolled in this prospective study. Patients' urinary symptoms and erectile function were evaluated using the International Prostate Symptom Score (IPSS) and International Index of Erectile Function-5 (IIEF-5) questionnaires the day before and 1 month after PB. Also, using uroflowmetry, the patients' urinary peak flow rate (Qmax) was recorded. SPSS version 18 was used to compare and analyze variables. Results The mean age of the participants was 67.47 ± 9.38 years. Before the PB, the IIEF-5 score was 20.19 ± 7.24, and after the PB, it was 20.25 ± 7.24 (p = 0.865). The Qmax level rose from 7.35 ± 2.15 to 7.74 ± 2 ml/s (p = 0.07). After TRUS-guided PB, the average IPSS score reduced from 11.48 ± 9.93 to 9.88 ± 8.22 which was statistically significant (p < 0.001). Conclusions This study indicated that TRUS-guided PB had no negative impact on erectile function or LUTS in participants and may even relieve urinary symptoms to some extent. Overally, TRUS-guided PB appears to be a safe strategy for evaluating prostate cancer suspects.

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“…Men with BPH-related LUTS often report feelings of embarrassment and frustration, which can lead to social isolation and reduced participation in social activities. This can negatively affect their mental health, leading to feelings of loneliness, depression, and low self-esteem (Vartolomei et al, 2022). In addition, LUTS can affect mental health by causing sleep disturbances and disrupting daily activities, leading to fatigue and a reduced sense of well-being (Chow et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Mitigating Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: Ameliorating Sexual Function and Psychological Well-Being in Older Men

Chan,

Estivalet

et al. 2023

Am J Mens Health

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This study aimed to investigate the prevalence of lower urinary tract symptoms (LUTS) in older men ( N= 3056) with benign prostatic hyperplasia (BPH) and its effects on their sexual function and mental health. Descriptive, correlation, and regression analyses were used to explore the relationships between prostate and lower urinary tract health and psychological well-being. Better prostate and lower urinary tract health positively affected psychological well-being, and sexual function also had a positive influence. LUTS have an adverse impact on sexual function and mental health. Early intervention is crucial for mitigating the negative impact of LUTS on the quality of life in older men. Addressing prostate and lower urinary tract health issues through appropriate interventions may improve psychological well-being. Health care professionals must consider the adverse effects of BPH and LUTS on sexual function and mental health, and implement interventions to enhance the overall quality of life in older men.

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Lower urinary tract symptoms are associated with clinically relevant depression, anxiety, and stress symptoms

Cited by 11 publications

References 19 publications

Evaluation of Lower Urinary Tract Symptoms in Males and Urinary Incontinence in Females in Primary Health Care in Greece

Evaluation of Lower Urinary Tract Symptoms in Males and Urinary Incontinence in Females in Primary Health Care in Greece

The effect of transrectal ultrasound-guided prostate biopsy on erectile function and lower urinary tract symptoms: a prospective study

Mitigating Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: Ameliorating Sexual Function and Psychological Well-Being in Older Men

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