Lower urinary tract symptoms and urodynamic findings in children and adults with cerebral palsy: A systematic review

Samijn, Bieke; Laecke, Erik Van; Renson, Catherine; Hoebeke, Piet; Plasschaert, Frank; Walle, Johan Vande; Broeck, Christine Van den

doi:10.1002/nau.22982

Cited by 51 publications

(37 citation statements)

References 56 publications

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“…Certainly, children with complex chronic neuromuscular conditions (eg, cerebral palsy) are at risk for impaired innervation of bladder musculature 36 that often subsists silently, going undetected while steadily increasing in severity. 37 The severity could potentially worsen with perioperative exposures (eg, shifts in fluid volume, pain medications, etc) and result in subsequent pain from overfilling as well as constipation and infection.…”

Section: Figurementioning

confidence: 99%

Comorbidities and Complications of Spinal Fusion for Scoliosis

Berry

Glotzbecker²,

Rodean

et al. 2017

Pediatrics

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Section: Figurementioning

confidence: 99%

Comorbidities and Complications of Spinal Fusion for Scoliosis

Berry

Glotzbecker²,

Rodean

et al. 2017

Pediatrics

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“…Considering the nature of the underlying disease, children with cerebral palsy have delayed and incomplete development of the bladder. It means that they have reduced bladder capacity with uninhibited bladder contractions, which has potentially negative effects on the upper urinary tract and bladder capacity [6].…”

Section: Discussionmentioning

confidence: 99%

Two Pediatric Cases of Successful Management of Postictal Transient Urinary Retention

et al. 2020

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We report two cases of postictal urinary retention in pediatric patients with cognitive impairment. Two girls with intellectual disabilities, concomitant cerebral palsy (case 1) and Rett syndrome (case 2), developed urinary retention following seizures. Their caregivers brought them to the hospital with complaints of abdominal distension. After excluding neurological progression, they were referred to the rehabilitation clinic for the evaluation and management of postictal urinary retention. We followed two different approaches in each case to restore normal urination. While serial manual cystometrograms were performed in case 1, clean intermittent catheterization with a voiding diary was performed in case 2 until restoration of normal urination. Based on these pediatric cases of successfully managed postictal urinary retention, we suggest that more attention may be needed for children with cognitive impairment to diagnose and manage postictal urinary retention.

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“…Furthermore, among a small sample of Cerebral Palsy patients referred for urologic symptoms 20 of 27 had incontinence, 2 of 27 had retention problems, and 13 of 27 had a history of UTI [35]. A systematic meta-analysis of 27 studies on lower urinary tract symptoms in individuals with Cerebral Palsy suggest more than half develop lower urinary tract symptoms at some point [36]. It is difficult to make direct comparisons on prevalence and incidence rates between these studies on individuals with Cerebral Palsy with our results on individuals with RTT.…”

Section: Discussionmentioning

confidence: 99%

Loss of MeCP2 Causes Urological Dysfunction and Contributes to Death by Kidney Failure in Mouse Models of Rett Syndrome

et al. 2016

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Rett Syndrome (RTT) is a neurodevelopmental disorder characterized by loss of acquired skills during development, autonomic dysfunction, and an increased risk for premature lethality. Clinical experience identified a subset of individuals with RTT that present with urological dysfunction including individuals with frequent urinary tract infections, kidney stones, and urine retention requiring frequent catheterization for bladder voiding. To determine if urologic dysfunction is a feature of RTT, we queried the Rett Syndrome Natural History Study, a repository of clinical data from over 1000 individuals with RTT and found multiple instances of urological dysfunction. We then evaluated urological function in a mouse model of RTT and found an abnormal pattern of micturition. Both male and female mice possessing Mecp2 mutations show a decrease in urine output per micturition event. Furthermore, we identified signs of kidney failure secondary to urethral obstruction. Although genetic strain background significantly affects both survival and penetrance of the urethral obstruction phenotype, survival and penetrance of urethral obstruction do not directly correlate. We have identified an additional phenotype caused by loss of MeCP2, urological dysfunction. Furthermore, we urge caution in the interpretation of survival data as an endpoint in preclinical studies, especially where causes of mortality are poorly characterized.

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Lower urinary tract symptoms and urodynamic findings in children and adults with cerebral palsy: A systematic review

Abstract: The significant prevalence of LUTS, risk for deterioration, and the impact of urinary tract symptoms on quality of life and health status warrants the need for evaluation and treatment in further research. Neurourol. Urodynam. 36:541-549, 2017. © 2016 Wiley Periodicals, Inc.

Cited by 51 publications

References 56 publications

Comorbidities and Complications of Spinal Fusion for Scoliosis

Comorbidities and Complications of Spinal Fusion for Scoliosis

Two Pediatric Cases of Successful Management of Postictal Transient Urinary Retention

Loss of MeCP2 Causes Urological Dysfunction and Contributes to Death by Kidney Failure in Mouse Models of Rett Syndrome

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