Lower serum magnesium is a predictor of left ventricular hypertrophy in patients on dialysis

Balafa, Olga; Dounousi, Evangelia; Giannikouris, Ioannis; Petrakis, Ioannis; Georgoulidou, Anastasia; Karassavidou, Despina; Kokalis, Apostolos; Stauroulopoulos, Aristeidis; Theodoridis, Marios; Oikonomidis, Ignatios; Triantafyllis, Georgios; Tsotsorou, Ourania; Tzannis, Kimon; Bacharaki, Dimitra

doi:10.1007/s11255-022-03391-2

Cited by 1 publication

(2 citation statements)

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“…injection of a magnesium salt has already been shown to improve cardiac hypertrophy in a mouse model of myocardial fibrosis [ 47 ]. Even though numerous studies highlight the evidence of hypomagnesemia in CKD [ 1 , 46 , 48 ], we did not detect significant changes in the serum magnesium levels in any group. Thus, we cannot conclude on the precise impact of hypomagnesemia here.…”

Section: Discussioncontrasting

confidence: 95%

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Magnesium Improves Cardiac Function in Experimental Uremia by Altering Cardiac Elastin Protein Content

et al. 2023

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Cardiovascular complications are accompanied by life-threatening complications and represent the major cause of death in patients with chronic kidney disease (CKD). Magnesium is important for the physiology of cardiac function, and its deficiency is common in CKD. In the present study, we investigated the impact of oral magnesium carbonate supplementation on cardiac function in an experimental model of CKD induced in Wistar rats by an adenine diet. Echocardiographic analyses revealed restoration of impaired left ventricular cardiac function in animals with CKD. Cardiac histology and real-time PCR confirmed a high amount of elastin protein and increased collagen III expression in CKD rats supplemented with dietary magnesium as compared with CKD controls. Both structural proteins are crucial in maintaining cardiac health and physiology. Aortic calcium content increased in CKD as compared with tissue from control animals. Magnesium supplementation numerically lowered the increases in aortic calcium content as it remained statistically unchanged, compared with controls. In summary, the present study provides evidence for an improvement in cardiovascular function and aortic wall integrity in a rat model of CKD by magnesium, as evidenced by echocardiography and histology.

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Section: Discussioncontrasting

confidence: 95%

“…Cardiac hypertrophy is regarded as one hallmark of uremic cardiomyopathy, besides capillary changes and fibrosis [ 45 ]. On the other hand, lower serum magnesium was found to be independently associated with left ventricular hypertrophy in dialysis patients [ 46 ]. An i.p.…”

Section: Discussionmentioning

confidence: 99%