Lower serum levels of transforming growth factor-β<sub>1</sub> and disease activity in Takayasu arteritis

Savioli, Bruna; Salu, Bruno Ramos; Brito, Marlon Vilela de; Oliva, Maria Luíza Vilela; Souza, Alexandre Wagner Silva de

doi:10.1080/03009742.2019.1637454

Cited by 2 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TGFB1 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins, a profibrotic cytokine in M2 ( Cui et al, 2020 ). Compared the TGF-β level in serum of TA patients and healthy control and drew a conclusion that TGF-β is lower in TA, especially active TA ( Savioli et al, 2020 ). It demonstrated that TGF-β is a potential biomarker of disease activity assessment.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome profiling of abdominal aortic tissues reveals alterations in mRNAs of Takayasu arteritis

Miao

Gao

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

Takayasu arteritis (TA) is a chronic granulomatous vasculitis involving in the main branches of aorta. Previous studies mainly used peripheral blood and some vascular tissues but seldom studies have sequenced vascular tissues. Here in this study, we aimed to explore the alterations of mRNA in TA by performing bulk RNA sequencing. A total of 14 abdominal aortic tissues including 8 from renal transplantation and 6 from patient with TA undergoing bypass surgeries. Bulk RNA sequencing were performed and after the quality control, a total of 1897 transcripts were observed to be significantly differently (p < 0.05 and Log2FC > 1) expressed between the TA and control group, among which 1,361 transcripts were in TA group and 536 in the Control group. Reactome Pathway Enrichment Comparison analysis revealed interleukin-10 signaling and signaling by interleukins were highly expressed in TA group. Besides, extracellular matrix organization was also observed in this group. WGCNA and PPI obtained 26 core genes which were highly correlated with the clinical phenotype. We then also perform deconvolution of the bulk RNA-seq data by using the scRNA-seq dataset and noticed the high proportion of smooth muscle cells in our dataset. Additionally, immunohistochemical staining confirmed our bioinformatic analysis that TA aortic tissues express high levels of IL-1R1 and IL-1R2. Briefly, this study revealed critical roles of interleukins in TA pathogenesis, and SMCs may also participate in the reconstruction in vessel wall at late stage of TA.

show abstract

Section: Discussionmentioning

confidence: 99%

Transcriptome profiling of abdominal aortic tissues reveals alterations in mRNAs of Takayasu arteritis

Miao

Gao

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…It is interesting to note that the release and activation of TGF-β within ECM controlled by MMPs increases ECM deposition by stromal cells and fibrosis and may be inhibited by TIMPs [28]. Some studies have reported that the serum levels of TGF-β follow TA activity [29][30][31]. The differentiation of fibroblasts into myofibroblasts, regulated by the ECM molecules and TGF-β by stimulating α-smooth muscle actin (α-SMA), leads to higher collagen production within vessel walls [32,33].…”

Section: Discussionmentioning

confidence: 99%

Enhanced Liver Fibrosis Score as a Biomarker for Vascular Damage Assessment in Patients with Takayasu Arteritis—A Pilot Study

Stojanović

Rašković

Milivojević

et al. 2021

JCDD

View full text Add to dashboard Cite

Takayasu arteritis (TA) is characterized by granulomatous panarteritis, vessel wall fibrosis, and irreversible vascular impairment. The aim of this study is to explore the usefulness of the Enhanced Liver Fibrosis score (ELF), procollagen-III aminoterminal propeptide (PIIINP), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), and hyaluronic acid (HA) in assessing vascular damage in TA patients. ELF, PIIINP, TIMP-1, and HA were measured in 24 TA patients, and the results were correlated with the clinical damage indexes (VDI and TADS), an imaging damage score (CARDS), and disease activity scores (NIH and ITAS2010). A mean ELF score 8.42 (±1.12) and values higher than 7.7 (cut-off for liver fibrosis) in 21/24 (87.5%) of patients were detected. The VDI and TADS correlated significantly to ELF (p < 0.01). Additionally, a strong association across ELF and CARDS (p < 0.0001), PIIINP and CARDS (p < 0.001), and HA and CARDS (p < 0.001) was observed. No correlations of the tested biomarkers with inflammatory parameters, NIH, and ITAS2010 scores were found. To our knowledge, this is the first study that suggests the association of the serum biomarkers PIIINP, HA, and ELF score with damage but not with disease activity in TA patients. The ELF score and PIIINP may be useful biomarkers reflecting an ongoing fibrotic process and quantifying vascular damage.

show abstract

Lower serum levels of transforming growth factor-β₁ and disease activity in Takayasu arteritis

Cited by 2 publications

References 8 publications

Transcriptome profiling of abdominal aortic tissues reveals alterations in mRNAs of Takayasu arteritis

Transcriptome profiling of abdominal aortic tissues reveals alterations in mRNAs of Takayasu arteritis

Enhanced Liver Fibrosis Score as a Biomarker for Vascular Damage Assessment in Patients with Takayasu Arteritis—A Pilot Study

Contact Info

Product

Resources

About

Lower serum levels of transforming growth factor-β1 and disease activity in Takayasu arteritis

Cited by 2 publications

References 8 publications

Transcriptome profiling of abdominal aortic tissues reveals alterations in mRNAs of Takayasu arteritis

Transcriptome profiling of abdominal aortic tissues reveals alterations in mRNAs of Takayasu arteritis

Enhanced Liver Fibrosis Score as a Biomarker for Vascular Damage Assessment in Patients with Takayasu Arteritis—A Pilot Study

Contact Info

Product

Resources

About

Lower serum levels of transforming growth factor-β₁ and disease activity in Takayasu arteritis