Lower Serum Irisin Levels Are Associated with Increased Vascular Calcification in Hemodialysis Patients

Lian, He; He, Wan-Yu; Lata, A; Yang, Wenling; Zhang, Aihua

doi:10.1159/000487689

Cited by 30 publications

(17 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also found that irisin serum levels were lower in post-menopausal women with PHPT compared to control subjects [19]. This finding supported results from other previous clinical investigations showing that irisin was inversely correlated with PTH in postmenopausal women with low bone mass [14] and in hemodialysis patients [47]. Moreover, our study also showed that irisin treatment decreases the expression of PTH receptor in osteoblasts, suggesting that this myokine may exert its anabolic effect on bone not only by stimulating osteoblast formation and function, but also by reducing the action of PTH on these cells [19].…”

Section: Irisin In Primary Hyperparathyroidismsupporting

confidence: 88%

Irisin and Bone: From Preclinical Studies to the Evaluation of Its Circulating Levels in Different Populations of Human Subjects

Colaianni

Sanesi

Storlino

et al. 2019

Cells

View full text Add to dashboard Cite

Almost four years after the discovery of the anabolic action of irisin on bone in mice, ample clinical evidence is emerging in support of its additional physiological relevance in human bone. Irisin inversely correlates with sclerostin levels in adults with prediabetes and with vertebral fragility fractures in post-menopausal women. Furthermore, in athletes we observed a positive correlation between irisin and bone mineral density at different anatomical sites. Our group also described a positive association between serum irisin and bone status in healthy children and multivariate regression analysis showed that irisin is a stronger determinant of bone mineral status than bone alkaline phosphatase. In children with type 1 diabetes mellitus, serum irisin concentrations are positively associated with bone quality and with glycemic control following continuous subcutaneous insulin infusion. Additionally, our in vitro studies suggest the existence of a negative interplay between PTH and irisin biology and these results were also supported by the observation that post-menopausal women with primary hyperparathyroidism have lower levels of irisin compared to matched controls. In this review, we will focus on recent findings about circulating level of irisin in different populations of human subjects and its correlation with their bone status.

show abstract

Section: Irisin In Primary Hyperparathyroidismsupporting

confidence: 88%

Irisin and Bone: From Preclinical Studies to the Evaluation of Its Circulating Levels in Different Populations of Human Subjects

Colaianni

Sanesi

Storlino

et al. 2019

Cells

View full text Add to dashboard Cite

show abstract

“…Our study is the first to identify that lower serum irisin significantly correlated with VC in PD patients. Consistently, He et al [5] reported that hemodialysis patients with VC had lower serum irisin levels than patients without VC. Several mechanisms could explain our findings.…”

Section: Discussionmentioning

confidence: 62%

“…In addition, recent studies have indicated that irisin may play roles in calcium and phosphate homoeostasis and promote bone formation [4]. He et al [5] found that lower irisin concentrations were associated with VC in hemodialysis patients. However, the effect of irisin on VC in PD patients remains unclear and no relative study was reported.…”

Section: Introductionmentioning

confidence: 99%

Lower Serum Irisin Levels Are Associated with Increased Abdominal Aortic Calcification in Peritoneal Dialysis Patients

et al. 2021

Self Cite

View full text Add to dashboard Cite

Introduction: Vascular calcification (VC), with the mechanisms remaining unclear, is closely related with dialysis patients’ cardiovascular mortality and all-cause mortality. Irisin is a newly identified myokine. This study aims to evaluate the serum irisin levels of peritoneal dialysis (PD) patients and their relationship with VC. Methods: This cross-sectional study enrolled stable PD patients in Peking University Third Hospital who were followed for >6 months. We used plain X-ray films of abdomen to quantitatively evaluate VC of abdominal aorta. VC was evaluated by abdominal aortic calcification (AAC) scores, and PD patients were divided into the high AAC score group (AAC score ≥4) and the low AAC score group (AAC score <4). Demographic data and laboratory indexes were collected. Serum irisin concentrations were measured by enzyme-linked immunosorbent assay. Results: A total of 102 PD patients were enrolled in this study, and 52 patients (51.0%) were found to have a high AAC score of ≥4. Age, diabetic mellitus proportion, pulse pressure, hypercalcemia (corrected calcium >2.54 mmol/L) rate, serum ultrasensitive C reactive protein, and AAC scores were significantly higher in the high AAC score group than those of the low AAC score group (p < 0.05). The high AAC score group had lower diastolic blood pressure, serum albumin, and serum carbon dioxide combining power compared with the low AAC score group (p < 0.05). Serum irisin levels of PD patients with a high AAC score were significantly lower than those of PD patients with a low AAC score (109.7 ± 13.1 ng/mL vs. 115.9 ± 10.1 ng/mL, p = 0.010). The multivariate logistic regression analyses showed that serum irisin, diabetic mellitus, serum ultrasensitive C reactive protein, and age were independent factors influencing the occurrence of VC in PD patients. Conclusion: Our results are the first to provide a clinical evidence of the association between serum irisin and abdominal aortic calcification in PD patients. Lower irisin levels, diabetic mellitus, higher serum ultrasensitive C reactive protein, and older age could be potential predictive factors for VC in PD patients.

show abstract

“…Furthermore, Lee et al (31) demonstrated that serum irisin was significantly associated with carotid atherosclerosis in peritoneal dialysis patients. He et al also found that irisin was associated with increased vascular calcification in HD patients (32). Additionally, Wu et al announced that a low serum irisin level is a predictor of poor early functional outcome in ischemic stroke patients (6).…”

Section: Discussionmentioning

confidence: 99%

Lower serum irisin levels are associated with the increasing mortality of cardiovascular and cerebrovascular diseases in hemodialysis patients

Dong¹,

Fu²,

Deng³

et al. 2021

Ann Palliat Med

View full text Add to dashboard Cite

Background: Irisin is a recently discovered myokine/adipokine and lower levels of irisin were proved to be associated with adverse outcomes of cardiovascular and cerebrovascular diseases (CCVD) in general population. A significant decrease of irisin concentrations were also detected in patients with chronic kidney disease (CKD). In the present study, we investigated whether the serum irisin levels were associated with cardiovascular and cerebrovascular mortality in hemodialysis (HD) patients.Methods: This retrospective cohort study enrolled 152 HD patients. Kaplan-Meier analysis was used to estimate the cumulative mortality of CCVD. The differences between the survival curves were compared by log-rank test. A multivariable Cox regression analysis was employed to identify the predictors of CCVD related deaths.Results: Among 152 HD patients, 55 patients died and 18 of them died of CCVD, 97 HD patients survived. Compared with the survival group, patients died of CCVD had significantly lower serum irisin levels [23.6 (2.2, 319.4) vs. 45.7 (2.1, 367.8) ng/mL, P<0.05]. The Kaplan-Meier survival curves showed that patients with lower levels of irisin had higher CCVD mortality. The Cox regression analysis indicated lower irisin level as an independent risk factor for CCVD mortality in HD patients but not for all-cause mortality.Conclusions: Our results provided an association between lower irisin level and CCVD mortality in HD patients. Lower levels of irisin increased the mortality of CCVD in HD patients.

show abstract

Lower Serum Irisin Levels Are Associated with Increased Vascular Calcification in Hemodialysis Patients

Cited by 30 publications

References 40 publications

Irisin and Bone: From Preclinical Studies to the Evaluation of Its Circulating Levels in Different Populations of Human Subjects

Irisin and Bone: From Preclinical Studies to the Evaluation of Its Circulating Levels in Different Populations of Human Subjects

Lower Serum Irisin Levels Are Associated with Increased Abdominal Aortic Calcification in Peritoneal Dialysis Patients

Lower serum irisin levels are associated with the increasing mortality of cardiovascular and cerebrovascular diseases in hemodialysis patients

Contact Info

Product

Resources

About