Lower serum 25-hydroxyvitamin D levels are associated with impaired glomerular filtration rate in type 2 diabetes patients

Dall’Agnol, Angélica; Brondani, Letícia de Almeida; Cancelier, Vítor da Agostim; Camargo, Eduardo Guimarães; Silveiro, Sandra Pinho

doi:10.1177/2042018820930904

Cited by 6 publications

(6 citation statements)

References 47 publications

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“…All of them support that VDD is associated with increased risk of PAD and diabetic foot ulcer formation, while the RCT concludes that VD supplementation for 12 weeks can improve wound healing. Regarding diabetic nephropathy, two studies (one cross-sectional and one retrospective study) [ 27 - 28 ] showed that VDD is associated with decreased glomerular filtration rate (GFR) and in addition VD status can be used to identify patients at increased risk of developing nephropathy complications. Although, an RCT [ 29 ] supports that VD supplementation resulted in no significant improvement of eGFR at five years.…”

Section: Reviewmentioning

confidence: 99%

Vitamin D Deficiency in Elderly With Diabetes Mellitus Type 2: A Review

Papaioannou¹,

Πανταζίδου²,

Kokkalis³

et al. 2021

Cureus

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Diabetes mellitus type 2 (T2DM) is an emerging public health issue with high prevalence among older adults (>60 years old). Taking into consideration the great increase in the elderly population (approximately 7.5 billion worldwide), we can easily understand the impact of this chronic disease and its complications. On the other hand, vitamin D deficiency (VDD) is also a serious public health problem with significant impacts and multiple health effects. The correlation between DM and VDD has been suggested and established from many observational studies, reviews, and meta-analyses. The literature in PubMed and Google Scholar was searched for relevant articles published up to October 2020. The keywords used were the following: vitamin D deficiency, elderly, and diabetes mellitus type 2. Among the 556 articles retrieved, 90 full texts were eligible and only 34 studies (12 retrospective studies, two prospective cohorts, three meta-analyses, seven cross-sectional studies, nine randomized control trials (RCTs), and one observational study) met the inclusion criteria for the review. The author's name, year of publication, country, type of study, and the number of patients were reported. According to this review there is adequate evidence to support the correlation between VDD and T2DM in the elderly. The results from the RCTs are more conflicting and more studies are needed to confirm the impact of vitamin D deficiency (VD) supplementation on metabolic and lipid profile, oxidative stress, and the complications of T2DM in older patients. VDD is clearly related with severe retinopathy, diabetic peripheral neuropathy, and poor cognition performance, while there is consensus about the beneficial effect of VD on peripheral artery disease, foot ulceration prevention, and wound healing. On the other hand, there is controversy about the effect of VD supplementation on cardiovascular adverse events, endothelial function, and estimated glomerular filtration rate (eGFR). Finally, the association of VDD with fragility fractures and depression in the elderly with T2DM is currently insufficiently studied and remains controversial.

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Section: Reviewmentioning

confidence: 99%

Vitamin D Deficiency in Elderly With Diabetes Mellitus Type 2: A Review

Papaioannou¹,

Πανταζίδου²,

Kokkalis³

et al. 2021

Cureus

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“…Circulating 25-hydroxyvitamin D levels is regarded as a sensitive determination of vitamin D status [ 27 ] and the prevalence of vitamin D insufficiency and deficiency was found to be higher in type 2 diabetic patients with chronic kidney disease and albuminuria compared to those without albuminuria [ 28 ]. In a recent study, lower 25-hydroxyvitamin D concentration was associated with reduced GFR in type 2 diabetic patients, but there was no difference between patients with elevated urinary albumin excretion compared to those with normoalbuminuria [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Cystatin C, Vitamin D and Thyroid Function Test Profile in Chronic Kidney Disease Patients

et al. 2021

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Background: The progression of chronic kidney disease (CKD) is concomitant with complications, including thyroid dysfunction, dyslipidemia and cardiovascular diseases. The aim of this study is to determine serum cystatin C levels, and the prevalence of vitamin D deficiency and thyroid dysfunction in CKD patients. Methods: A cross-sectional study was conducted involving 140 CKD patients (stages 1–5) that were referred to a renal clinic. Demographic data was collected and thyroid function tests, serum 25-OH-vitamin D, cystatin C levels, and routine biochemistry tests were determined using cobas 6000 analyzer. Results: 129 (92.1%) of CKD patients had elevated serum cystatin C levels and there was a stepwise increase from stage 1–5. Overt hypothyroidism was present in one patient and nine had subclinical hypothyroidism. There was a stepwise reduction in serum 25-OH-vitamin D levels from stage 2–5, 31 (22.1%) had vitamin D insufficiency and 31 (22.1%) presented with deficiency. Conclusions: 25-OH-vitamin D deficiency and thyroid disorders are exhibited in chronic kidney disease patients and the severity of the former rises with disease progression, as indicated by elevated cystatin C levels. Routine screening and timely intervention is recommended so as to reduce the risk of cardiovascular diseases.

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“…After a full‐text assessment for eligibility, 141 articles were excluded. Ultimately, 23 articles were included in the meta‐analysis, 10–32 as shown in the PRISMA 33 (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Progression of diabetic nephropathy and vitamin D serum levels: A pooled analysis of 7722 patients

Dean,

Elawady,

Shi

et al. 2023

Endocrino Diabet & Metabol

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Background and AimLow serum Vitamin D levels have been associated with diabetic nephropathy (DN). Our study aimed to analyse the serum levels of vitamin D in patients suffering from DN and the subsequent changes in serum vitamin D levels as the disease progresses.MethodsPubMed, Embase, SCOPUS and Web of Science were searched using keywords such as ‘25 hydroxyvitamin D’ and ‘diabetic nephropathy’. We included observational studies that reported the association between the serum 25 hydroxy vitamin D levels and diabetic nephropathy without restriction to age, gender, and location. R Version 4.1.2 was used to perform the meta‐analysis. The continuous outcomes were represented as mean difference (MD) and standard deviation (SD) and dichotomous outcomes as risk ratios (RR) with their 95% confidence interval (CI).ResultsTwenty‐three studies were included in our analysis with 7722 patients. Our analysis revealed that vitamin D was significantly lower in diabetic patients with nephropathy than those without nephropathy (MD: −4.32, 95% CI: 7.91–0.74, p‐value = .0228). On comparing diabetic patients suffering from normoalbuminuria, microalbuminuria, or macroalbuminuria, we found a significant difference in serum vitamin D levels across different groups. Normoalbuminuria versus microalbuminuria showed a MD of −1.69 (95% CI: −2.28 to −1.10, p‐value = .0002), while microalbuminuria versus macroalbuminuria showed a MD of (3.75, 95% CI: 1.43–6.06, p‐value = .0058), proving that serum vitamin D levels keep declining as the disease progresses. Notwithstanding, we detected an insignificant association between Grade 4 and Grade 5 DN (MD: 2.29, 95% CI: −2.69–7.28, p‐value = .1862).ConclusionSerum Vitamin D levels are lower among DN patients and keep declining as the disease progresses, suggesting its potential benefit as a prognostic marker. However, on reaching the macroalbuminuria stage (Grades 4 and 5), vitamin D is no longer a discriminating factor.

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Lower serum 25-hydroxyvitamin D levels are associated with impaired glomerular filtration rate in type 2 diabetes patients

Cited by 6 publications

References 47 publications

Vitamin D Deficiency in Elderly With Diabetes Mellitus Type 2: A Review

Vitamin D Deficiency in Elderly With Diabetes Mellitus Type 2: A Review

Cystatin C, Vitamin D and Thyroid Function Test Profile in Chronic Kidney Disease Patients

Progression of diabetic nephropathy and vitamin D serum levels: A pooled analysis of 7722 patients

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