Lower Serum 25-Hydroxyvitamin D Level is Associated With 3 Types of Autoimmune Thyroid Diseases

Abstract

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Vitamin D and autoimmune thyroid diseases

“…Every 5 nmol/l decrease in serum 25(OH)D 3 concentrations was associated with a 1.51-fold increase in PPT risk (95% CI 1.25-1.82). However, in this study predelivery calcidiol levels were not associated with TSH, anti-TPO or anti-TG levels (38).…”

“…However, no difference in the prevalence of vitamin D deficiency (25(OH)D 3 < 20 ng/ml) between 100 patients with AITD (52 HT, 48 GD) and 126 healthy controls was observed by D'Aurizio et al (11). Likewise, the relationship between low vitamin D levels and the presence of anti-TPO and anti-TG antibodies was not always observed (14,37,38,41). Goswami et al in a group of 642 subjects from India revealed only a weak inverse correlation between serum calcidiol and anti-TPO concentrations (r = -0.08, p = 0.04), but no association between vitamin D deficiency (25(OH)D 3 < 10 ng/ml) and anti-TPO positivity (33).…”

“…In the last years, several clinical studies indicated an association between vitamin D deficiency and autoimmune thyroid diseases (AITD) defined as elevated antithyroid antibodies with or without characteristic ultrasonographic features (diffuse parenchymal hypoechogenicity and/or heterogeneous echogenic pattern of thyroid gland) (20,(33)(34)(35)(36)(37)(38). Many authors observed that subjects with low vitamin D concentration had more frequently elevated anti-TPO antibodies (33)(34)(35)(36)(37)39) and/or anti-TG antibodies (35,36,40,41).…”

25-Hydroxyvitamin D serum level in Hashimoto&rsquo;s thyroiditis, but not Graves&rsquo; disease is relatively deficient

“…Yasuda et al [23] established that the serum vitamin D level in the group of 26 females, newly diagnosed with GD, was significantly lower than the group comprising of 46 healthy females (p<0.05). Ma et al [24] demonstrated that vitamin D level in 70 patients with newly diagnosed GD was substantially lower than that in the healthy control group. However, in the present study, we did not find significantly decreased vitamin D level in patients newly diagnosed with GD, which was contradictory to the previous studies.…”

The early repigmentation pattern of vitiligo is related to the source of melanocytes and by the choice of therapy: a retrospective cohort study

“…The results illustrated that NB-UVB therapy has more prominent effects than topical medications. It has also been reported that low serum levels of 25-hydroxyvitamin D are not only related to autoimmune diseases (such as inflammatory bowel disease 20,21 and autoimmune thyroid disease 22,23 ) but also associated with vitiligo. 24,25 Treatment with UVB could improve the serum levels of 25-hydroxyvitamin D, which is another functional mechanism of NB-UVB to treat vitiligo.…”