Lower risk for Down syndrome associated with longer oral contraceptive use: a case–control study of women of advanced maternal age presenting for prenatal diagnosis

Nagy, Gyula Richárd; Győrffy, Balázs; Nagy, Balázs; Rigó, János

doi:10.1016/j.contraception.2012.08.040

Cited by 11 publications

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References 12 publications

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“…Firstly, pregnancies among them are high-risk pregnancies with higher likelihood of adverse maternal and perinatal outcomes [13, 19–21]. Effective contraceptive use could help prevent pregnancies that are not intended among all categories of women including women in advanced reproductive age.…”

Section: Introductionmentioning

confidence: 99%

Factors influencing contraceptive use and non-use among women of advanced reproductive age in Nigeria

Solanke

2017

J Health Popul Nutr

100

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BackgroundFactors influencing contraceptive use and non-use among women of advanced reproductive age have been insufficiently researched in Nigeria. This study examines factors influencing contraceptive use and non-use among women of advanced reproductive age in Nigeria.MethodsSecondary data were pooled and extracted from 2008 and 2013 Nigeria Demographic and Health Surveys (NDHS). The weighted sample size was 14,450 women of advanced reproductive age. The dependent variable was current contraceptive use. The explanatory variables were selected socio-demographic characteristics and three control variables. Analyses were performed using Stata version 12. Multinomial logistic regression was applied in four models.ResultsMajority of the respondents are not using any method of contraceptive; the expected risk of using modern contraceptive relative to traditional method reduces by a factor of 0.676 for multiparous women (rrr = 0.676; CI: 0.464–0.985); the expected risk of using modern contraceptive relative to traditional method reduces by a factor of 0.611 for women who want more children (rrr = 0.611; CI: 0.493–0.757); the relative risk for using modern contraceptive relative to traditional method increases by a factor of 1.637 as maternal education reaches secondary education (rrr = 1.637; CI: 1.173–2.285); the relative risk for using modern contraceptive relative to traditional method increases by a factor of 1.726 for women in richest households (rrr = 1.726; CI: 1.038–2.871); and the expected risk of using modern contraceptive relative to traditional method increases by a factor of 1.250 for southern women (rrr = 1.250; CI: 1.200–1.818).ConclusionsSocio-demographic characteristics exert more influence on non-use than modern contraceptive use. The scope, content and coverage of existing BCC messages should be extended to cover the contraceptive needs and challenges of women of advanced reproductive age in the country.

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Section: Introductionmentioning

confidence: 99%

Factors influencing contraceptive use and non-use among women of advanced reproductive age in Nigeria

Solanke

2017

J Health Popul Nutr

100

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“…T21 oocytes appear to demonstrate slowed maturation in comparison with disomic oocytes . It is likely they could accumulate in the ovaries by escaping apoptotic elimination.…”

Section: Discussionmentioning

confidence: 93%

“…This could be of particular importance for pregnancies occurring in advanced maternal age. A previous study found that a history of longer oral contraceptive pill use was associated with fewer common fetal trisomies . However, a limitation of this study was that it used existing medical records only to record exposure history; smoking has been suggested as an unmeasured additional environmental risk factor for fetal trisomies …”

Section: Introductionmentioning

confidence: 99%

Effect of extended oral contraception use on the prevalence of fetal trisomy 21 in women aged at least 35 years

Horányi

Babay

Rigó

et al. 2017

Intl J Gynecology & Obste

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“…If we accept that, according to this theory, the trisomic oocytes may be retarded in their maturation in comparison with normal oocytes, we have the possibility of reducing trisomic pregnancies with the preservation of the ovarian oocyte reserve by reducing the number of unnecessary ovulations. One method of oocyte reserve preservation is surprisingly obvious: the application of oral contraceptive pills reduces redundant ovulations …”

Section: Discussionmentioning

confidence: 99%

Evidence for the Oocyte Mosaicism Selection model on the origin of Patau syndrome (trisomy 13)

Babay

Horányi

Győrffy

et al. 2019

Acta Obstet Gynecol Scand

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Introduction In 2008, Hultén et al hypothesized that maternal ovarian trisomy 21 mosaicism might be the primary causative factor for fetal Down syndrome. We hypothesize that this theory can be extended to trisomy 13. Material and methods We collected fetal ovarian tissue from seven female fetuses between 16 and 23 gestational weeks, following the termination of the pregnancy for non‐genetic reasons. All procedures were performed with informed consent and ethical approval from the local ethics committee. We used touch preparation techniques from fetal ovarian tissues and an anti‐stromal antigen 3 antibody against the meiosis‐specific stromal antigen 3 protein to differentiate between germ cells, ovarian stromal cells and the cells entering their first meiotic prophase. We used fluorescence in situ hybridization analysis to determine chromosome 13 numbers in each cell. Results We were able to detect a proportion of trisomy 13 cells in all cases. The average incidence of trisomy 13 cells was 2.04% in stromal antigen 3‐positive and 0.91% in the stromal antigen 3‐negative cells. The number of the trisomic cells increased significantly with gestational age (for stromal antigen 3‐positive cells r = 0.93, P = 0.0038, for stromal antigen 3‐negative cells r = 0.85, P = 0.0071). Conclusions This study indicates that besides trisomy 21, the Oocyte Mosaicism Selection model could be extended to trisomy 13 as well. The crucial factor for trisomy 13 seems to be the pre‐meiotic/mitotic trisomy 13 mosaicism, leading to a so‐called secondary meiotic nondisjunction of those oocytes having three copies of chromosome 13.

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Lower risk for Down syndrome associated with longer oral contraceptive use: a case–control study of women of advanced maternal age presenting for prenatal diagnosis

Cited by 11 publications

References 12 publications

Factors influencing contraceptive use and non-use among women of advanced reproductive age in Nigeria

Factors influencing contraceptive use and non-use among women of advanced reproductive age in Nigeria

Effect of extended oral contraception use on the prevalence of fetal trisomy 21 in women aged at least 35 years

Evidence for the Oocyte Mosaicism Selection model on the origin of Patau syndrome (trisomy 13)

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