Lower Quadriceps Rate of Force Development Is Associated With Worsening Physical Function in Adults With or at Risk for Knee Osteoarthritis: 36-Month Follow-Up Data From the Osteoarthritis Initiative

Hu, Bo; Skou, Søren Thorgaard; Williams, Glenn N.; Nevitt, Michael C.; Segal, N.A.

doi:10.1016/j.apmr.2017.12.027

Cited by 14 publications

(8 citation statements)

References 53 publications

(55 reference statements)

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“…However, in contrast to our results, the patients in the former study also displayed only moderate and not statistically significant reductions in peak torque compared with the control group. Despite no apparent differences between the knee osteoarthritis patients and healthy controls in terms of RTD, this variable was suggested to be strongly related to the physical function in patients with knee osteoarthritis [18,38]. Future investigations should assess RTD, RTD-SF and RTR-SF, along with the relevant functional tests to determine which outcome correlates most strongly with the physical function.…”

Section: Discussionmentioning

confidence: 94%

Adapted protocol of rate of force development and relaxation scaling factor for neuromuscular assessment in patients with knee osteoarthritis

et al. 2020

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Background: The linear relationship between muscle torque and rate of torque rise/relaxation during rapid muscle contractions has been recently introduced as a novel measure of muscle quickness, termed rate of torque development/relaxation scaling factor (RTD-SF/RTR-SF). Because the standard assessment protocol includes potentially painful muscle contractions, the first purpose of this study was to validate an adapted RTD-SF/RTR-SF protocol for knee extensor muscles that utilizes lower submaximal intensities and can be used in knee osteoarthritis patients. Methods: A cross-sectional study was performed on a group of healthy controls (n = 24) who underwent the standard RTD-SF/RTR-SF protocol (20-80% of maximum) and the knee osteoarthritis group (n = 24) who underwent the adapted protocol (20-60% of maximum). We calculated the RTD-SF, RTR-SF and the linearity (r 2 ) for both relationships, based on both protocols in controls. Results: The validity of the adapted protocol was acceptable (intraclass correlation coefficient = 0.77-0.93), with low within-participant variation (coefficient of variability <10%) for both outcome measures. Compared with the control group, the knee osteoarthritis group had similar RTD-SF, but lower linearity of RTD-SF (0.90 vs. 0.82). The RTR-SF (8.0/s vs. 6.7/s) and its linearity (0.87 vs. 0.73) were significantly reduced. Comparing the affected and the unaffected leg in the knee osteoarthritis group, the unaffected leg had greater maximal torque (96.2 vs. 84.1 Nm) and higher linearity for RTD-SF (0.86 vs. 0.80) and RTR-SF (0.82 vs. 0.73). Conclusions: We confirmed the validity of the adapted RTD/RTR-SF protocol and its sensitivity to impairments associated with knee osteoarthritis.

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Section: Discussionmentioning

confidence: 94%

Adapted protocol of rate of force development and relaxation scaling factor for neuromuscular assessment in patients with knee osteoarthritis

et al. 2020

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“…Data from a number of studies this past year show the varying consequences of low muscle force development rates on outcomes relevant to OA. Using the large dataset from the Osteoarthritis Initiative, Hu et al showed that a higher rate of quadriceps force development may be protective against self-reported functional decline over a 3-year period in those with or at risk for knee OA 48 . After analyzing quadriceps force development data in tertiles, they found that those in the highest tertile had a 36% lower risk of worsening physical function, as quantified by the WOMAC.…”

Section: Osteoarthritis Andcartilagementioning

confidence: 99%

Osteoarthritis year in review 2019: mechanics

Hunt

Charlton

Esculier

2020

Osteoarthritis and Cartilage

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Mechanics play a critical e but not sole e role in the pathogenesis of osteoarthritis, and recent research has highlighted how mechanical constructs are relevant at the cellular, joint, and whole-body level related to osteoarthritis outcomes. This review examined papers from April 2018 to April 2019 that reported on the role of mechanics in osteoarthritis etiology, with a particular emphasis on studies that focused on the interaction between movement and tissue biomechanics with other clinical outcomes relevant to the pathophysiology of osteoarthritis. Studies were grouped by themes that were particularly prevalent from the past year. Results of the search highlighted the large exposure of knee-related research relative to other body areas, as well as studies utilizing laboratory-based motion capture technology. New research from this past year highlighted the important role that rate of exerted loads and rate of muscle force development e rather than simply force capacity (strength) e have in OA etiology and treatment. Further, the role of muscle activation patterns in functional and structural aspects of joint health has received much interest, though findings remain equivocal. Finally, new research has identified potential mechanical outcome measures that may be related to osteoarthritis disease progression. Future research should continue to combine knowledge of mechanics with other relevant research techniques, and to identify mechanical markers of joint health and structural and functional disease progression that are needed to best inform disease prevention, monitoring, and treatment.

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“…Therefore, with regard to muscle contraction time, the RFD may be more closely related to daily activities than maximum strength. In fact, it has been reported that RFD in KOA patients was signi cantly associated with activities of daily living score 12 and biomechanical gait variables 13 . These ndings collectively suggest that the RFD is more closely associated with daily activities than maximal strength.…”

Section: Introductionmentioning

confidence: 99%

Rate of Force Development in the Quadriceps of Individuals With Severe Knee Osteoarthritis: A Cross-Sectional Study

Suzuki

Iijima

Nakamura

et al. 2021

Preprint

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We tested the following hypotheses: individuals with severe knee osteoarthritis (KOA) would display a significantly decreased quadriceps rate of force development (RFD); and this decrease would be greater than the decrease in maximum quadriceps strength. Maximum isometric strength of the quadriceps was assessed in individuals with mild (Kellgren and Lawrence [K&L] grade 1–2) and severe KOA (K&L grade 3–4). RFD was analyzed at 200 ms from torque onset and normalized to body mass and maximum voluntary isometric contraction torque. The decrease in quadriceps RFD and the difference between this and the decrease in maximum quadriceps strength was tested with logistic regression analysis with a propensity-score-adjusted model and analysis of covariance, respectively. Effect size by Hedges’ g with a 95% confidence interval (CI) was calculated for the quadriceps RFD and maximum quadriceps strength. Sixty-six participants were analyzed. Individuals with severe KOA displayed significantly decreased quadriceps RFD (odds ratio: 0.50; 95% CI: 0.26-0.82), the decrease being greater than that in maximum quadriceps strength (between-group difference, ES: 0.88, -1.07 vs. 0.06, -0.22). The results suggest that a decreased quadriceps RFD is a modifiable risk factor for progressive KOA. This could lead to the early detection and prevention of severe KOA.

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Lower Quadriceps Rate of Force Development Is Associated With Worsening Physical Function in Adults With or at Risk for Knee Osteoarthritis: 36-Month Follow-Up Data From the Osteoarthritis Initiative

Abstract: Our results indicate that higher RFD is associated with decreased risk for worsening self-reported physical function but not with decreased risk for worsening of physical performance.

Cited by 14 publications

References 53 publications

Adapted protocol of rate of force development and relaxation scaling factor for neuromuscular assessment in patients with knee osteoarthritis

Adapted protocol of rate of force development and relaxation scaling factor for neuromuscular assessment in patients with knee osteoarthritis

Osteoarthritis year in review 2019: mechanics

Rate of Force Development in the Quadriceps of Individuals With Severe Knee Osteoarthritis: A Cross-Sectional Study

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