Lower Plasma Adiponectin Levels Are Associated with Larger Tumor Size and Metastasis in Clear-Cell Carcinoma of the Kidney

Pinthus, Jehonathan H.; Kleinmann, Nir; Tisdale, Britton; Chatterjee, Suman; Lu, Jianping; Gillis, Aubrey; Hamlet, Tamika; Singh, Gurmit; Farrokhyar, Forough; Kapoor, Anil

doi:10.1016/j.eururo.2008.02.044

Cited by 81 publications

(51 citation statements)

References 30 publications

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“…Pinthus et al [35] reported adiponectin to be related to the size of tumor and metastatic disease in clear cell renal cancer irrespective of BMI, age, and sex. In our study, serum adiponectin levels were found to be significantly lower in metastatic uveal melanoma cases, but tumor size was not associated with adiponectin.…”

Section: Discussionmentioning

confidence: 98%

Serum adiponectin, insulin resistance, and uveal melanoma

Sevim

Kıratlı

2016

Melanoma Research

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To investigate the status of insulin resistance, metabolic syndrome, dyslipidemia, and serum adiponectin levels in patients with uveal melanoma and choroidal nevus were investigated. Our study included 86 patients with uveal melanoma, 38 patients with choroidal nevus, and 86 controls. Uveal melanomas were classified as small, medium, and large on the basis of Collaborative Ocular Melanoma Study (COMS) criteria. Patients with uveal melanoma had significantly higher homeostatic model assessment scores compared with patients with choroidal nevus (P<0.001). Patients with uveal melanoma and choroidal nevus had significantly lower levels of serum adiponectin compared with controls (P<0.001). Patients with uveal melanoma who developed systemic metastases had significantly lower levels of serum adiponectin levels compared with patients with nonmetastases during follow-up (P=0.018). When the largest tumors (COMS III) were compared, ciliary body melanomas were associated with significantly lower levels of serum adiponectin than choroidal melanomas. In patients who were treated with enucleation, epitheloid predominant and mixed cell-type tumors were associated with lower levels of serum adiponectin compared with tumors with spindle cell type, but this did not reach statistical significance. By providing an antiapoptotic and proangiogenic environment, low serum adiponectin levels and insulin resistance may play a role in promoting the growth of uveal melanocytic tumors and may contribute toward a more aggressive clinical course, adversely affecting the prognosis.

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Section: Discussionmentioning

confidence: 98%

Serum adiponectin, insulin resistance, and uveal melanoma

Sevim

Kıratlı

2016

Melanoma Research

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“…Among these hormones, adiponectin is of particular significance owing to its protective antiangiogenic activity. Circulating adiponectin is inversely correlated with the amount of VAT [18], while decreased concentrations of adiponectin are associated with Type 2 diabetes, elevated glucose levels, hypertension, cardiovascular disease and certain malignancies [7,18]. Consequently, it may be important to complement adiponectin measures with calculations of VAT to better understand the pathogenesis of obesity-related disorders in the human population.…”

Section: Clinical Implications Of Obesitymentioning

confidence: 99%

The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysis

Shuster¹,

Patlas²,

Pinthus³

et al. 2012

BJR

668

570

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ABSTRACT. As a result of the rising epidemic of obesity, understanding body fat distribution and its clinical implications is critical to timely treatment. Visceral adipose tissue is a hormonally active component of total body fat, which possesses unique biochemical characteristics that influence several normal and pathological processes in the human body. Abnormally high deposition of visceral adipose tissue is known as visceral obesity. This body composition phenotype is associated with medical disorders such as metabolic syndrome, cardiovascular disease and several malignancies including prostate, breast and colorectal cancers. Quantitative assessment of visceral obesity is important for evaluating the potential risk of development of these pathologies, as well as providing an accurate prognosis. This review aims to compare different methods of measuring visceral adiposity with emphasis on their advantages and drawbacks in clinical practice.

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“…Serum APN levels have been negatively correlated with RCC, its tumor stage and its metastasis [127][128][129] . However, a more recent study found a positive association between APN levels and RCC risk, which appeared to vary with ethnicity 130 .…”

Section: Renal Cell Carcinoma (Rcc)mentioning

confidence: 99%

Evolving role of adiponectin in cancer-controversies and update

Katira¹,

Tan²

2016

Cancer Biology &Amp; Medicine

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Adiponectin (APN), an adipokine produced by adipocytes, has been shown to have a critical role in the pathogenesis of obesityassociated malignancies. Through its receptor interactions, APN may exert its anti-carcinogenic effects including regulating cell survival, apoptosis and metastasis via a plethora of signalling pathways. Despite the strong evidence supporting this notion, some work may indicate otherwise. Our review addresses all controversies critically. On the whole, hypoadiponectinaemia is associated with increased risk of several malignancies and poor prognosis. In addition, various genetic polymorphisms may predispose individuals to increased risk of obesity-associated malignancies. We also provide an updated summary on therapeutic interventions to increase APN levels that are of key interest in this field. To date efforts to manipulate APN levels have been promising, but much work remains to be done.

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Lower Plasma Adiponectin Levels Are Associated with Larger Tumor Size and Metastasis in Clear-Cell Carcinoma of the Kidney

Cited by 81 publications

References 30 publications

Serum adiponectin, insulin resistance, and uveal melanoma

Serum adiponectin, insulin resistance, and uveal melanoma

The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysis

Evolving role of adiponectin in cancer-controversies and update

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