“…Of the 1436 reports screened, 68 studies 14-17,24-87 fulfilled the selection criteria and were used for the systematic review and metaanalysis (eFigure 1 in the Supplement). These studies included 14 037 patients, of whom 4277 (30.5%) were classified as having GCA ( 16,17,[24][25][26][27][28][29][30][31][32][33][34][35]37,38,[40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][59][60][61][62][66][67][68][69]72,73,[75][76][77][78][79][80][81][82][83][84]…”
Section: Study Characteristicsmentioning
confidence: 99%
“…16,47,53,57,58,63,71,73,75,83 h From 7 of the analyzed studies. 43,48,56,60,63,67,86 i From 4 of the analyzed studies. 37, 63,75,79 j From 5 of the analyzed studies.…”
Section: Limitationsmentioning
confidence: 99%
“…37, 63,75,79 j From 5 of the analyzed studies. 43,56,67,79,86 k From 14 of the analyzed studies. 30,32,35,39,46,50,52,64,71,73,80,82,84,87 l Defined as at least 0.5 mg/dL unless other laboratory-specific reference values were reported.…”
IMPORTANCE Current clinical guidelines recommend selecting diagnostic tests for giant cell arteritis (GCA) based on pretest probability that the disease is present, but how pretest probability should be estimated remains unclear. OBJECTIVE To evaluate the diagnostic accuracy of symptoms, physical signs, and laboratory tests for suspected GCA.
“…Of the 1436 reports screened, 68 studies 14-17,24-87 fulfilled the selection criteria and were used for the systematic review and metaanalysis (eFigure 1 in the Supplement). These studies included 14 037 patients, of whom 4277 (30.5%) were classified as having GCA ( 16,17,[24][25][26][27][28][29][30][31][32][33][34][35]37,38,[40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][59][60][61][62][66][67][68][69]72,73,[75][76][77][78][79][80][81][82][83][84]…”
Section: Study Characteristicsmentioning
confidence: 99%
“…16,47,53,57,58,63,71,73,75,83 h From 7 of the analyzed studies. 43,48,56,60,63,67,86 i From 4 of the analyzed studies. 37, 63,75,79 j From 5 of the analyzed studies.…”
Section: Limitationsmentioning
confidence: 99%
“…37, 63,75,79 j From 5 of the analyzed studies. 43,56,67,79,86 k From 14 of the analyzed studies. 30,32,35,39,46,50,52,64,71,73,80,82,84,87 l Defined as at least 0.5 mg/dL unless other laboratory-specific reference values were reported.…”
IMPORTANCE Current clinical guidelines recommend selecting diagnostic tests for giant cell arteritis (GCA) based on pretest probability that the disease is present, but how pretest probability should be estimated remains unclear. OBJECTIVE To evaluate the diagnostic accuracy of symptoms, physical signs, and laboratory tests for suspected GCA.
“…Repeat Bland-Altman analysis excluding subjects with positive temporal artery biopsy did not improve the limits of agreement on tonometry measurements. The role of OPA in giant cell arteritis is discussed in a separate publication [ 12 ].…”
Section: Resultsmentioning
confidence: 99%
“…Also, our analysis did not change with adjustments for higher refractive errors. Refractive error may be lenient, but inadequate proxy for CCT, as myopia has been correlated with thinner CCT [ 12 - 14 ]. Notwithstanding other sources have found no systematic correlation between CCT and refractive error [ 15 ].…”
Background:Dynamic Contour Tonometry (DCT) is touted to be the most accurate tonometer for Intraocular Pressure (IOP) measurement. Non-Contact “air puff” Tonometry (NCT) may be the most commonly used tonometer for screening of IOP. Elevated IOP is important to exclude in patients presenting with headache or vision loss.Objective:To determine the agreement between DCT and NCT.Methods:The IOP of adult patients 50 years of age or older presenting with headache or vision loss for possible temporal artery biopsy were prospectively recorded. NCT and DCT measurements were obtained within thirty minutes. The right eye IOP measurements were compared with paired t-test, and Bland- Altman plot analysis. The left eye IOP measurements were subsequently analyzed for confirmation of results.Results:There were 106 subjects with complete right eye data, and 104 subjects with complete left eye data. The average age was 72 years, and 70% were female. The NCT IOP was on average 3.9 mm Hg lower in the right eye, and 3.5 mm Hg lower in the left eye compared with DCT. (p<.001) In the right eye the Bland-Altman analysis showed the 95% agreement interval between the two tonometers was -2.5 to 10.4 mmHg and in the left eye -3.0 to 9.9 mmHg.Conclusion:The IOP from NCT and DCT should not be used interchangeably because their level of disagreement includes clinically important discrepancies of up to 10 mm Hg.
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