Lower numbers of erythrocytes and lower levels of hemoglobin in periodontitis patients compared to control subjects

Abstract

The present study provides further evidence that periodontitis has systemic effects and that periodontitis may tend towards anemia. This phenomenon may be explained by a depressed erythropoiesis.

Anemia and Periodontitis: An Enigma?

“…Current study states that periodontitis is also a chronic disease that can result in lower hemoglobin percent and is in accordance with Hutter et al study 7 .Although lower hemaglobin levels in periodontitis patients was observed , the MCV and MCH values which is Hb per erythrocyte is comparable between three groups .It is important to note lower levels of Hb% in periodontitis is not due to iron or vitamin deficiencies since the MCV values are not altered 15. Mild to moderate anemia has been reported as a manifestation of several chronic diseases, infections and neoplasms .Hence the term anemia of chronic disease (ACD) came into being where ACD is defined as the anemia occurring in chronic infections, inflammatory conditions or neoplastic disorders that is not caused by marrow deficiencies or other diseases, and occurring despite the presence of adequate iron stores and vitamins. 8,13 It is a type of microcytic anemia.…”

“…Anemia is defined as the deficiency in the oxygen carrying capacity of blood either due to reduced hemoglobin %(Hb%) or reduced Red Blood Corpuscles( RBC )count. Many studies have seen association of anemia in periodontitis patients and the possible etiology cited for decreased blood counts was the downregulation of erythropoiesis in the bone marrow by proinflammatory cytokines released due to periodontal disease 6,7 This condition is termed as anemia of chronic disease (ACD) and is defined as the anemia occurring in chronic infections, inflammatory conditions or neoplastic disorders that is not caused by marrow deficiencies or other diseases, and occurring despite the presence of adequate iron stores and vitamins 8 It is a type of microcytic anemia. 9,10 H The present study was undertaken to investigate any association between periodontitis and anemia in healthy, gingivitis and periodontitis patients.…”

Effect of Smoking on Levels of Calcium, Magnesium and Blood Parameters in Patients With Chronic Periodontitis.

“…Recent reports also suggest a reduction in Hb% and RBC count in subjects with chronic periodontitis. (29,30). These facts indicate that periodontitis has an influence on systemic health.…”

Prevalência da doença periodontal em pacientes com doença renal crônica em hemodiálise

“…Além disso, dentro da periodontia, alguns estudos se propuseram a avaliá-los, a fim de entender melhor essa correlação (Hutter et al, 2001;Frankenthal et al, 2002;D'Aiuto et al, 2005). Em geral, os valores estavam dentro do normal, com exceção do PTH e HDL.…”

“…O PTH de todos os grupos estava aumentado e não influenciou na DP e edentulismo (Chen et al, e 2011de Souza et al 2014). Sustentados pela possibilidade da DP ser capaz de suprimir a eritropoiese (Hutter et al, 2001), Rahmati et al (2002) e Chen et al (2006 encontraram associação entre DP e anemia em indivíduos 5D em HD. Neste estudo, bem como em de de Souza et al (2014) essa interação não foi sugerida; o mesmo ocorreu para colesterol.…”