Lower muscular strength is associated with smaller left and right chambers and lower cardiac mass in the general population – The Sedentary's Heart

Markus, Marcello Ricardo Paulista; Ittermann, Till; Kim, Simon; Schipf, Sabine; Siewert-Markus, Ulrike; Santana, Camila Campos; Buchmann, Nikolaus; Völzke, Henry; Bülow, Robin; Felix, Stephan B.; Bahls, Martin; Steinhagen‐Thiessen, Elisabeth; Dörr, Marcus

doi:10.1016/j.pcad.2021.09.004

Cited by 10 publications

(13 citation statements)

References 57 publications

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“…Pulse rate was negatively associated with leg extension strength in both the sexes. Our grip strength results are consistent with those of previous cross-sectional studies that demonstrated no significant association between grip strength and heart rate [ 17 , 49 ]. We could not identify reports indicating an association between leg strength and pulse rate; nonetheless, exercises that maintain and improve the lower extremity muscle strength decreases the resting heart rate [ 50 ], thus supporting our results.…”

Section: Discussionsupporting

confidence: 92%

“…The positive association between blood pressure and grip strength can be explained as follows: Takase et al reported that the fat-free mass index was positively associated with the prevalence of hypertension [ 20 ]. Markus et al reported that lower grip strength was associated with lower structural and functional parameters of the heart [ 49 ]. Thus, high muscle mass and grip strength may serve as markers of cardiac strength and high blood pressure, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study

Noji,

Hatanaka,

Nakaya

et al. 2024

BMC Public Health

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Background Upper and lower extremity muscle strength can be used to predict health outcomes. However, the difference between the relation of upper extremity muscle and of lower extremity muscle with physiological factors is unclear. This study aimed to evaluate the association between physiological data and muscle strength, measured using grip and leg extension strength, among Japanese adults. Methods We conducted a cross-sectional study of 2,861 men and 6,717 women aged ≥ 20 years living in Miyagi Prefecture, Japan. Grip strength was measured using a dynamometer. Leg extension strength was measured using a hydraulic isokinetic leg press machine. Anthropometry and physiological data, including blood pressure, calcaneal ultrasound bone status, pulmonary function, carotid echography, and blood information, were assessed. We used a general linear model adjusted for age, body composition, and smoking status to evaluate the association between muscle strength and physiological factors. Results Grip and leg extension strength were positively associated with bone area ratio, vital capacity, forced vital capacity, forced expiratory volume in one second, and estimated glomerular filtration rate, and negatively associated with waist circumference and percentage body fat mass in both the sexes. Diastolic blood pressure was positively associated with grip strength in both the sexes and leg extension strength in men, but not women. High-density lipoprotein cholesterol and red blood cell counts were positively associated with grip and leg extension strength in women, but not men. In both the sexes, pulse rate, total cholesterol, and uric acid were consistently associated with only leg extension strength, but not grip strength. In women, glycated hemoglobin demonstrated negative and positive associations with grip and leg extension strength, respectively. Conclusions Grip and leg extension strength demonstrated similar associations with anthropometry, pulmonary function, and estimated glomerular filtration rate, but the associations with the other factors were not always consistent.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study

Noji,

Hatanaka,

Nakaya

et al. 2024

BMC Public Health

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“…8 Moreover, a sedentary lifestyle and its accompanying pathophysiological mechanisms are not necessarily the reverse of those related with vigorous physical activity and exercise training. 13 Recent studies published by our group, [14][15][16][17] using echocardiographic or magnetic resonance imaging (MRI) examination, showed that low levels of VO 2peak or handgrip strength (a marker of muscular fitness) were significantly associated with a smaller and stiffer heart, which we have called "the sedentary's heart". In a similar way, we aimed to analyse the effects of a sedentary lifestyle on other organs such as the liver.…”

Section: Introductionmentioning

confidence: 99%

Low cardiopulmonary fitness is associated with higher liver fat content and higher gamma‐glutamyltransferase concentrations in the general population – “The Sedentary’s Liver”

Zinterl

Ittermann

Schipf

et al. 2022

Liver International

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Background:We investigated the association between low cardiorespiratory fitness and liver fat content (LFC) in the general population. Materials and Methods:We evaluated data from 2151 adults (51.1% women) from two population-based cohorts of the Study of Health in Pomerania (SHIP-2 and SHIP-TREND-0). We analysed the cross-sectional associations of peak oxygen uptake (VO 2peak ) with LFC, assessed by magnetic resonance imaging proton density fat fraction, as well as serum gamma-glutamyltransferase (GGT) and aminotransferase concentrations by multivariable regression models. Results:We observed significant inverse associations of VO 2peak with LFC and serum GGT, but not with serum aminotransferase levels. Specifically, a 1 L/min lower VO 2peak was associated with a 1.09% (95% confidence interval [CI]: 0.45-1.73; P = .002) higher LFC and a 0.18 μkatal/L (95% CI: 0.09-0.26; P < .001) higher GGT levels. The adjusted odds ratio (OR) for the risk of prevalent hepatic steatosis (HS) by a 1 L/min decrease Funding informationThe Study of Health in Pomerania (SHIP) is part of the Community Medicine Research net (CMR) (http://www.mediz in.uni-greif swald.de/icm) of the University Medicine Greifswald, which is

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“…Thus, lower muscular fitness was related with lower Left ventricular wall thickness and mass, as well as with smaller chamber sizes, stroke volume and cardiac output of the left ventricle, left atrium, and right ventricle. Moreover, HGS was inversely related to left ventricular diastolic stiffness and NT-proBNP values [ 100 ]. The findings of these three analyses might demonstrate the effects of an aging-related decrease in physical activity and lower muscular fitness on the heart.…”

Section: Resultsmentioning

confidence: 99%

SHIP-MR and Radiology: 12 Years of Whole-Body Magnetic Resonance Imaging in a Single Center

et al. 2021

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The Study of Health in Pomerania (SHIP), a population-based study from a rural state in northeastern Germany with a relatively poor life expectancy, supplemented its comprehensive examination program in 2008 with whole-body MR imaging at 1.5 T (SHIP-MR). We reviewed more than 100 publications that used the SHIP-MR data and analyzed which sequences already produced fruitful scientific outputs and which manuscripts have been referenced frequently. Upon reviewing the publications about imaging sequences, those that used T1-weighted structured imaging of the brain and a gradient-echo sequence for R2* mapping obtained the highest scientific output; regarding specific body parts examined, most scientific publications focused on MR sequences involving the brain and the (upper) abdomen. We conclude that population-based MR imaging in cohort studies should define more precise goals when allocating imaging time. In addition, quality control measures might include recording the number and impact of published work, preferably on a bi-annual basis and starting 2 years after initiation of the study. Structured teaching courses may enhance the desired output in areas that appear underrepresented.

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Lower muscular strength is associated with smaller left and right chambers and lower cardiac mass in the general population – The Sedentary's Heart

Cited by 10 publications

References 57 publications

Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study

Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study

Low cardiopulmonary fitness is associated with higher liver fat content and higher gamma‐glutamyltransferase concentrations in the general population – “The Sedentary’s Liver”

SHIP-MR and Radiology: 12 Years of Whole-Body Magnetic Resonance Imaging in a Single Center

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