Lower Household Transmission Rates of SARS-CoV-2 from Children Compared to Adults - Results from the FamilyCoviDD19-Study

Galow, Lukas

doi:10.2139/ssrn.3790443

Cited by 3 publications

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“…21 22 In addition, these results support studies showing that certain quarantine and separation measures can effectively reduce the probability of viral transmission even in closecontact situations. 23 The fact that we could not detect one additional seropositive participant in over 4 months is surprising even in a low-prevalence setting, given that the reported cases doubled in the same period of time in Saxony. One explanation might be the recently reported detection of SARS-CoV-2 spike-reactive CD4+ T cells in 35% of SARS-CoV-2-unexposed healthy blood donors arguing for a certain level of T-cell cross-reactivity.…”

Section: Discussionmentioning

confidence: 85%

SARS-CoV-2 seroprevalence in students and teachers: a longitudinal study from May to October 2020 in German secondary schools

et al. 2021

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ObjectiveTo quantify the number of SARS-CoV-2 infections in secondary schools after their reopening in May 2020.DesignRepeated SARS-CoV-2 seroprevalence study after the reopening of schools and 4 months later.SettingSecondary school in Dresden, Germany.Participants1538 students grades 8–12 and 507 teachers from 13 schools.InterventionsSerial blood sampling and SARS-CoV-2 IgG antibody assessment.Primary and secondary outcome measureSeroprevalence of SARS-CoV-2 antibodies in study population. Number of undetected cases.Results1538 students and 507 teachers were initially enrolled, and 1334 students and 445 teachers completed both study visits. The seroprevalence for SARS-CoV-2 antibodies was 0.6% in May/June and the same in September/October. Even in schools with reported COVID-19 cases before the lockdown of 13 March, no clusters could be identified. Of 12 persons with positive serology five had a known history of confirmed COVID-19; 23 out of 24 participants with a household history of COVID-91 were seronegative.ConclusionsSchools do not play a crucial role in driving the SARS-CoV-2 pandemic in a low-prevalence setting. Transmission in families occurs very infrequently, and the number of unreported cases is low in this age group. These observations do not support school closures as a strategy fighting the pandemic in a low-prevalence setting.Trial registration numberDRKS00022455.

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Section: Discussionmentioning

confidence: 85%

SARS-CoV-2 seroprevalence in students and teachers: a longitudinal study from May to October 2020 in German secondary schools

et al. 2021

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“…Evidence indicates that children seldom develop a severe clinical presentation of SARS-COV2 infection and are less prone to transmit it than adults ( 1 – 4 ). For example, in China, more than 90% of infected children had a mild or moderate clinical presentation, a finding consistent with later reports ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

Covid-19 Incidence and Mortality by Age Strata and Comorbidities in Mexico City: A Focus in the Pediatric Population

González-García

Castilla-Peón

Santos

et al. 2021

Front. Public Health

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Background: SARS-COV2 appears less frequently and less severely in the pediatric population than in the older age groups. There is a need to precisely estimate the specific risks for each age group to design health and education policies suitable for each population.Objective: This study aimed to describe the risk of death in SARS-COV2 infected subjects by age group and according to the presence of comorbidities.Methods: We analyzed data of confirmed SARS-COV2 infection cases where symptoms began between February 22th, 2020, and April 18th, 2021, as published by the General Epidemiology Direction (DGE) of the Mexican Ministry of Health. We calculated COVID-19 incidence and mortality by age group using population data from the Statistics and Population National Institute (INEGI), and estimated the association between risk of death and the presence of comorbidities.Results: Mortality in SARS-COV2 infected people varied considerably, between 7 and 155 deaths per million per year in the under-20 age groups compared to 441 to 15,929 in the older age groups. Mortality in pediatric populations is strongly associated with comorbidities (OR: 4.6-47.9) compared to the milder association for older age groups (OR: 3.16–1.23).Conclusion: The risk of death from SARS-COV2 infection in children is low and is strongly associated with comorbidities.

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“…Evidence indicates that children seldom develop a severe clinical presentation of SARS-COV2 infection and are less prone to transmit it than adults (1–4). For example, in China, more than 90% of the infected children had a mild or moderate clinical presentation, a finding consistent with later reports (5,6).…”

Section: Introductionmentioning

confidence: 99%

Covid-19 Incidence And Mortality By Age Strata And Comorbidities In Mexico City: A Focus In The Pediatric Population

González-García

Castilla-Peón

Santos

et al. 2021

Preprint

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IntroductionSARS-COV2 appears less frequently and less severely in the pediatric population than in older age groups. In the face of the urgent need to reactivate activities suspended during the lockdown, mainly those essential for child development, this study aims to describe the risks of death of persons infected with SARS-COV2 by age group and according to the presence of comorbidities.MethodologyWe analyzed data of confirmed SARS-COV2 infection cases where symptoms began between February 22th, 2020, and March 31, 2021, as published by the General Epidemiology Direction (DGE) of the Mexican Ministry of Health. We calculated COVID-19 incidence and mortality by age group with population data from the Statistics and Population National Institute (INEGI), estimating the correlation between risk of death and the presence of comorbidities.ResultsMortality in SARS-COV2 infected people varied considerably, between 7 to 155 deaths per million per year in the under-20 age groups compared to 441 to 15929 in the older age groups. Mortality in pediatric populations is strongly associated with comorbidities (OR: 4.6-47.9) compared to the milder association for older age groups (OR: 3.16-1.23).ConclusionsThe risk of death from SARS-COV2 infection in children is low and strongly associated with comorbidities.

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Lower Household Transmission Rates of SARS-CoV-2 from Children Compared to Adults - Results from the FamilyCoviDD19-Study

Cited by 3 publications

References 0 publications

SARS-CoV-2 seroprevalence in students and teachers: a longitudinal study from May to October 2020 in German secondary schools

SARS-CoV-2 seroprevalence in students and teachers: a longitudinal study from May to October 2020 in German secondary schools

Covid-19 Incidence and Mortality by Age Strata and Comorbidities in Mexico City: A Focus in the Pediatric Population

Covid-19 Incidence And Mortality By Age Strata And Comorbidities In Mexico City: A Focus In The Pediatric Population

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