Lower-Grade Gliomas: An Epidemiological Voxel-Based Analysis of Location and Proximity to Eloquent Regions

Vecchio, Tomás Gómez; Neimantaite, Alice; Corell, Alba; Bártek, Jiří; Jensdottir, Margret; Reinertsen, Ingerid; Solheim, Ole; Jakola, Asgeir Store

doi:10.3389/fonc.2021.748229

Cited by 7 publications

(3 citation statements)

References 64 publications

(76 reference statements)

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“…Among 80 percent of LGGs and secondary glioblastoma accompanied with IDH1-mut character are usually younger than people with IDH1-wt. The proportion of temporal lobe tumors is significantly higher in IDH1-wt glioma, which often has histopathological features of oligodendroglioma 8,31 . Combined with the postoperative molecular pathology, we found that about 1/5 of the patients required a revised diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Rapid detection of isocitrate dehydrogenase 1 mutation status in glioma based on Crispr-Cas12a

Feng

Kong

Jin

et al. 2023

Sci Rep

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The aim is to use Crispr-Cas12a for the rapid detection of the single nucleotide polymorphism (SNP) of isocitrate dehydrogenase 1 (IDH1)-R132H locus and explore the effectiveness and consistency of this method with direct sequencing method for detecting IDH1-R132H of glioma tissue samples. 58 previous frozen tissue and 46 recent fresh tissue samples of adult diffuse glioma were selected to detect IDH1-R132H using Crispr-Cas12a. The results of immunohistochemistry (IHC) and direct sequencing methods were analyzed. We calculated the efficiency index of Crispr-Cas12a and IHC, and analyzed the consistency among Crispr-Cas12a, IHC and direct sequencing method using paired Chi-sequare test and Kappa identity test. We accomplished the rapid detection of IDH1-R132H in 60 min using Crispr-Cas12a. Regarding direct sequencing method as the gold standard, the sensitivity, specificity and consistency rate of Crispr-Cas12a was 91.4%, 95.7% and 93.1% in the frozen sample group, while 96.1%, 89.7% and 92.0% in the fresh sample group, respectively. Kappa test showed good consistency between the two methods (k = 0.858). Crispr-Cas12a can quickly and accurately detect IDH1-R132H and has good stability. It is a promising method to detect IDH1 mutation status intraoperatively.

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Section: Discussionmentioning

confidence: 99%

Rapid detection of isocitrate dehydrogenase 1 mutation status in glioma based on Crispr-Cas12a

Feng

Kong

Jin

et al. 2023

Sci Rep

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“…Standard preprocessing was done using Functional Magnetic Resonance Imaging of the Brain Software Library (FLS) as described previously. 44 MRIs were individually registered to the Montreal Neurological Institute (MNI) space, of which the T1 symmetric MNI 09a was used as registration target. 45 Tumor segmentations and MRIs transformed to MNI space were individually controlled for errors or unexpected deformations by raters with experience in glioma image analysis (A.C., A.N., and T.G.V.).…”

Section: Methodsmentioning

confidence: 99%

Stemness and clinical features in relation to the subventricular zone in diffuse lower-grade glioma: an exploratory study

Corell

Vecchio

Vega

et al. 2022

Neuro-Oncology Advances

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Background The subventricular zone (SVZ) of the human brain is a site of adult stem cell proliferation and a microenvironment for neural stem cells (NSCs). It has been suggested that NSCs in the SVZ are potential cells of origin containing driver mutations of glioblastoma, but their role in the origin of diffuse lower-grade gliomas (dLGG) is not much studied. Methods We included 188 patients ≥18 years with IDH-mutated dLGG (WHO grade 2–3) histologically diagnosed between 2007–2020. Tissue microarrays of tumor samples for patients between 2007–2016 were used for immunodetection of Nestin, SOX2, SOX9, KLF4, NANOG, CD133 cMYC and Ki67. DNA methylation profile was used for stemness index (mDNAsi). Tumor contact with the SVZ was assessed and the distance was computed. Results Overall, 70.2% of the dLGG had SVZ contact. Tumors with SVZ contact were larger (102.4 vs. 30.9 ml, p<0.01), the patients were older (44.3 vs. 40.4 years, p=0.04) and more often had symptoms related to increased intracranial pressure (ICP) (31.8% vs. 7.1%, p<0.01). The expression of SOX2, SOX9, Nestin and Ki67 showed inter-sample variability, but no difference was found between tumors with or without SVZ contact, nor with the actual distance to the SVZ. mDNAsi was similar between groups (p=0.42). Conclusion We found no statistical relationship between proximity with the SVZ and mDNAsi or expression of SOX2, SOX9, Nestin and Ki67 in IDH-mutated dLGG. Our data suggests that the potential impact of SVZ on IDH-mutated dLGG is probably not associated with a more stemness-like tumor profile.

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“…Anatomical magnetic resonance imaging (MRI) T2-weighted image (T2) or fluid-attenuated inversion-recovery (FLAIR) sequences were used to assess tumor volume using software 3D Slicer (15) according to our previously reported method (16). Multifocal lesions were classified according to the largest tumor.…”

Section: Methodsmentioning

confidence: 99%

Classification of Adverse Events Following Surgery in Patients With Diffuse Lower-Grade Gliomas

et al. 2021

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BackgroundRecently, the Therapy-Disability-Neurology (TDN) was introduced as a multidimensional reporting system to detect adverse events in neurosurgery. The aim of this study was to compare the novel TDN score with the Landriel–Ibanez classification (LIC) grade in a large cohort of patients with diffuse lower-grade glioma (dLGG). Since the TDN score lacks validation against patient-reported outcomes, we described health-related quality of life (HRQoL) change in relation to TDN scores in a subset of patients.MethodsWe screened adult patients with a surgically treated dLGG World Health Organization (WHO) grade 2 and 3 between 2010 and 2020. Up until 2017, it consists of a retrospective cohort (n = 158). From 2017 and onwards, HRQoL was registered using EuroQoL-5-dimension, three levels of response (EQ-5D 3L) questionnaire at baseline and 3 months follow-up, in a prospectively recruited cohort (n = 102). Both the LIC grade and TDN score were used to classify adverse events.ResultsIn total, 231 patients were included. In 110/231 (47.6%) of the surgical procedures, a postoperative complication was registered. When comparing the TDN score to LIC grades, only a minor shift towards complications of higher order could be observed. EQ-5D 3L was reported for 45 patients. Patients with complications related to surgery had pre- to postoperative changes in EQ-5D 3L index values (n = 27; mean 0.03, 95% CI −0.06 to 0.11) that were comparable to patients without complications (n = 18; mean −0.06, 95% CI −0.21 to 0.08). In contrast, patients with new-onset neurological deficit had a deterioration in HRQoL at follow-up, with a mean change in the EQ-5D 3L index value of 0.11 (n = 13, 95% CI 0.0 to 0.22) compared to −0.06 (n = 32, 95% CI −0.15 to 0.03) for all other patients.ConclusionsIn patients with dLGG, TDN scores compared to the standard LIC tend to capture more adverse events of higher order. There was no clear relation between TDN severity and HRQoL. However, new-onset neurological deficit caused impairment in HRQoL. For the TDN score to better align with patient-reported outcomes, more emphasis on neurological deficit and function should be considered.

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Lower-Grade Gliomas: An Epidemiological Voxel-Based Analysis of Location and Proximity to Eloquent Regions

Cited by 7 publications

References 64 publications

Rapid detection of isocitrate dehydrogenase 1 mutation status in glioma based on Crispr-Cas12a

Rapid detection of isocitrate dehydrogenase 1 mutation status in glioma based on Crispr-Cas12a

Stemness and clinical features in relation to the subventricular zone in diffuse lower-grade glioma: an exploratory study

Classification of Adverse Events Following Surgery in Patients With Diffuse Lower-Grade Gliomas

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