Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass

Liang, Yuan; Yu, Ruili; He, Rui; Sun, Lichao; Luo, Cheng; Liu, Feng; Chen, Hong; Yin, Yue; Zhang, Weizhen

doi:10.3389/fendo.2022.891379

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…SG often has to deal with acid reflux, potentially causing Barrett disease and impairing patients’ quality of life ( 11 ). RYGB, on the other hand, combines a restrictive and a malabsorptive component coming along with major anatomical changes and metabolic reprogramming ( 26 , 27 ). RYGB is hence considered to be more effective for patients suffering from diabetes mellitus, arterial hypertension, and other manifestations of the metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Bariatric surgery in liver cirrhosis

et al. 2022

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IntroductionObesity is frequently associated with its hepatic manifestation, the nonalcoholic fatty liver disease (NAFLD). The most effective treatment for morbid obesity is bariatric surgery (BS) also improving NAFLD and liver function. In patients where NAFLD has already progressed to liver cirrhosis, BS can be considered a high-risk procedure. Hence, consideration of the procedure and the most appropriate timing is crucial.Material and MethodsObese patients suffering from NAFLD who underwent BS from two German University Medical Centers were retrospectively analyzed.ResultsTwenty-seven patients underwent BS. Most common procedures were laparoscopic Roux-en-Y-gastric (RYGB) and laparoscopic sleeve gastrectomy (SG). All patients suffered from liver cirrhosis Child A. A preoperative transjugular portosystemic shunt (TIPS) was established in three patients and failed in another patient. Postoperative complications consisted of wound healing disorders (n = 2), anastomotic bleeding (n = 1), and leak from the staple line (n = 1). This patient suffered from intraoperatively detected macroscopic liver cirrhosis. Excess weight loss was 73% and 85% after 1 and 2 years, respectively. Two patients suffered from postoperative aggravation of their liver function, resulting in a higher Child–Pugh score, while three could be removed from the waiting list for a liver transplantation.ConclusionBS leads to weight loss, both after SG and RYGB, and potential improvement of liver function in liver cirrhosis. These patients need to be considered with care when evaluated for BS. Preoperative TIPS implantation may reduce the perioperative risk in selected patients.

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Section: Discussionmentioning

confidence: 99%

Bariatric surgery in liver cirrhosis

et al. 2022

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The Efficacy of Roux-en-Y Gastric Bypass in Young-Onset Diabetes Mellitus: A Narrative Review

Bhatnagar,

Hingway,

Bawiskar

2024

Cureus

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Type 2 diabetes mellitus (T2DM) in youth is invading the communities because, if not controlled on time, the long-term complications include cardiovascular diseases, nephropathy, neuropathy, and retinopathy that cause immense mortality and morbidity. Lifestyle changes and antidiabetic drugs are considered the foundation of T2DM therapy. However, these adjustments usually do not effectively produce long-term glycemic regulation, especially in patients with obesity of the third and fourth degrees. Bariatric surgery has also been identified as an efficacious intervention for obesity and obesity-related complications such as T2DM. Roux-en-Y gastric bypass (RYGB) has proven to be one of the most effective procedures in causing considerable weight loss and enhancing glycemic changes. This review provides a comprehensive analysis of RYGB in patients with young-onset T2DM regarding the improvement of glycemic control, weight loss, and diabetes comorbidities. RYGB has been established as a practice in the treatment of T2DM and severe obesity. This narrative review underscores the various effects of RYGB, such as enhanced glycemic control, considerable and long-term weight loss, and reduced cardiovascular disease risks. However, the review also points toward the directions and the adverse effects of RYGB regarding metabolic and skeletal health. There are risks of nutritional deficiencies, increased fracture rates, and even relapse to diabetes, which make patient selection, proper pre and postoperative investigation, and critical monitoring.

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Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass

Cited by 2 publications

References 36 publications

Bariatric surgery in liver cirrhosis

Bariatric surgery in liver cirrhosis

The Efficacy of Roux-en-Y Gastric Bypass in Young-Onset Diabetes Mellitus: A Narrative Review

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