Lower genital tract rhabdomyosarcoma: case series and literature review

Ghaemmaghami, Fatemeh; Zarchi, Mojgan Karimi; Ghasemi, Mahsa

doi:10.1007/s00404-007-0503-5

Cited by 40 publications

(35 citation statements)

References 11 publications

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“…The mean age at diagnosis of patients with cervical lesion is higher than that of patients with vaginal lesions . Primary vaginal lesions are more common than cervical lesions [4]. We report a case of sarcoma botryoides of the cervix presenting as a cervical polyp in 20 year old female.…”

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confidence: 91%

Botryoid rhabdomyosarcoma of cervix - A Rare case report

Rao¹

2017

NMJ

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confidence: 91%

Botryoid rhabdomyosarcoma of cervix - A Rare case report

Rao¹

2017

NMJ

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“…2 Vaginal primaries are five times more common than cervical primaries. 3 The mean age at diagnosis of patients with ERMS arising in the cervix is higher than of patients with vaginal lesions. Although ERMS has been described in females as young as 5 months of age, it tends to appear in an older age group (children or even young adults) than those occurring in the vagina.…”

Section: Introductionmentioning

confidence: 99%

“…Although ERMS has been described in females as young as 5 months of age, it tends to appear in an older age group (children or even young adults) than those occurring in the vagina. 1,3 The Intergroup Rhabdomyosarcoma Study Group (IRSG) has reported a new classification of ERMS distinguishing three major histological subtypes: embryonal, alveolar and undifferentiated. The embryonal subtype is the most common, accounting for 68% of all ERMS cases, with classic, botryoid and spindle cell variants embracing 49, 6 and 3%, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…The embryonal subtype is the most common, accounting for 68% of all ERMS cases, with classic, botryoid and spindle cell variants embracing 49, 6 and 3%, respectively. 1,3,4 Sarcoma botryoides of the cervix uteri rarely occurs in fertile age since it only accounts for 0.2% of all malignant tumours of the uterus. 4 This sarcoma generally presents as soft nodules that fill and sometimes protrude from the vagina, resembling a bunch of grapes.…”

Section: Introductionmentioning

confidence: 99%

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Embryonal rhabdomyosarcoma of the uterine cervix: a rare case report

Gomes

Leite

Rocha

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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Embryonal rhabdomyosarcoma of the female genital tract is a rare tumour. It tends to occur during childhood in the vagina and, rarely, it can arise in the uterine cervix, with a peak incidence in the second decade. We report a case of a 18-year-old female with an embryonal rhabdomyosarcoma (sarcoma botryoides) presenting himself as a cervical polyp. This tumour consisted of rhabdomyoblasts with miscellaneous differentiation surrounded by a loose, myxoid stroma. The patient was successfully treated with cervical conization and adjuvant chemotherapy. She is now disease-free at the 28th month follow-up. Awareness of this uncommon lesion in the cervix and its clinical implications is important to prevent misdiagnosis. Therapy has recently inclined to conservative and fertility-sparing treatment.

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“…RMS is rare in adults, with soft-tissue sarcomas making up less than 1% of malignancies in adults and RMS accounting for 3% of all soft-tissue sarcomas. In University of Tehran data only 6 RMS were found (0.39%) among the 1,528 patients with genital tract malignancies [1]. In Korea, a total of 8 cases of RMS were reported in young adults but there has been no case in which the patient was older than 40 years.…”

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A case of embryonal rhabdomyosarcoma of the uterine cervix in a middle-aged woman

Shim

Lee

Paek

et al. 2011

Korean J Obstet Gynecol

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Embryonal rhabdomyosarcoma (RMS) of the cervix is rare and most commonly occurs in the late teens and early 20s. We report a case of cervical embryonal RMS in a 52-year-old woman. This patient presented with an abnormal vaginal bleeding for 2 months and a mass protruding from the introitus, measuring 7 × 6 cm. She underwent radical abdominal hysterectomy with bilateral pelvic lymph node dissection and radical vaginectomy. The fi nal pathologic result was cervical RMS, consistent with the Intergroup RMS study group IIC. Immunohistochemistry was positive for desmin, myogenin, and myogenic diffentiation 1. The patient received conservative management in a convalescent hospital without adjuvant treatment due to cerebral hemorrhage and relapsed septic condition after surgery.Keywords: Embryonal rhabdomyosarcoma; Uterine cervix CASE REPORT Received: 2011. 5.30. Accepted: 2011 Embryonal Rhabdomyosarcoma (RMS) is the most common soft tissue tumor in childhood and young adults. RMS is rare in adults, with soft-tissue sarcomas making up less than 1% of malignancies in adults and RMS accounting for 3% of all soft-tissue sarcomas. In University of Tehran data only 6 RMS were found (0.39%) among the 1,528 patients with genital tract malignancies [1]. In Korea, a total of 8 cases of RMS were reported in young adults but there has been no case in which the patient was older than 40 years. We report a case of cervical RMS in a 52-year-old woman who underwent radical surgery. Case ReportA 52-year-old multiparous woman presented with vaginal bleeding for several weeks and the feeling of a mass protruding from the introitus for 2 months. She has normal menstrual cycles. The patient was referred to our institute with a suspicion of a cervical myoma. In her medical history, she had been diagnosed with cerebral arteriovenous malformation and treated with embolization and gamma knife surgery a few months prior. On the vaginal examination, a 7 × 6 cm soft pinkish irregular mass arising from the uterine cervix and reaching up to the introitus was seen (Fig. 1). Biopsy was performed and the result was favoring sarcoma, most likely embryonal RMS. Magnetic resonance imaging and F-18 fl urodeoxyglucose (FDG) positron emission tomography/computed tomography also showed a 7 × 6 cm mass arising from the endocervix and protruding outside the vagina cavity to the perineal portion with FDG uptake (Fig. 2). Moreover, parametrial invasion was seen on posterior aspect of the uterine cervix. The serum level of CA-125 was 58.6 U/mL. Other laboratory tests showed no specifi c abnormality. Her height, weight, and body mass index were 156 cm, 53 kg, and 21.8 kg/m 2 , respectively. Based on the results of these imaging studies and the pathologic result of biopsy, the patient was diagnosed with sarcoma of the uterine cervix.

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Lower genital tract rhabdomyosarcoma: case series and literature review

Cited by 40 publications

References 11 publications

Botryoid rhabdomyosarcoma of cervix - A Rare case report

Botryoid rhabdomyosarcoma of cervix - A Rare case report

Embryonal rhabdomyosarcoma of the uterine cervix: a rare case report

A case of embryonal rhabdomyosarcoma of the uterine cervix in a middle-aged woman

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