Lower Gastrointestinal Tract Pathology in Saudis: Results of Endoscopic Biopsy Findings in 1,600 Patients

Mohamed, Abdelrahman E.; Al-Karawi, Mohamed A.; Hanid, M A; Yasawy, Ismail

doi:10.5144/0256-4947.1987.306

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…In the study by El-Sheikh Mohamed et al, the incidence of ulcerative colitis (1.75%) and Crohn's disease (0.19%) was observed to be low as compared to other research. 11 In our study, ulcerative colitis was seen in 8.16 % of colon biopsies and Crohn's disease was seen in 7.40% of ileal/ileocecal biopsies.…”

Section: Discussionsupporting

confidence: 46%

“…Non-specific colitis was observed as the second commonest histological finding in a study by El-Sheikh Mohamed et al, the first being Schistosoma infestation. 11 In their study, a low incidence of adenomatous polyps (2.69%) and colorectal cancer 90.78%) was seen. Non-specific colitis(6.80%), proctitis(12.24%), and ileitis(85.18% of ileal/ileocecal specimens) were the most frequent site-wise diagnosis in the present study as well.…”

Section: Discussionmentioning

confidence: 87%

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Histological study of endoscopic biopsies from the lower gastrointestinal tract

Banstola¹,

Thapa²,

Poudel³

et al. 2022

J Pathol Nep

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Background: Endoscopy of the gastrointestinal tract is seen as an essential diagnostic tool because it can provide an in-depth visual assessment of gastrointestinal mucosa and allows for tissue sampling. This study aims to find out the histological diagnosis of various tissues biopsied from the lower GIT endoscopically. Materials and methods: It is a retrospective observational study conducted in the Department of Pathology, Fewa City Hospital and Research Center, Pokhara, Nepal from March 2021 to February 2022. Results: Total number of samples taken into the study was 174. Nonspecific inflammation was the commonest lesion in ileal, colon, and rectal biopsies. Conclusions: Lower GI tract is targeted to a wide range of diseases, ranging from inflammatory to malignant entities. Endoscopy and biopsy for suspected lesions is a trusted approach for investigating and managing GI tract pathologies.

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Section: Discussionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 87%

Histological study of endoscopic biopsies from the lower gastrointestinal tract

Banstola¹,

Thapa²,

Poudel³

et al. 2022

J Pathol Nep

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“…The first study published in 1982 indicated that inflammatory bowel disease was rare or nonexistent in Saudi Arabia [ 1 ]. In the following years, multiple studies have suggested an increase in the incidence of IBD in Saudi Arabia [ 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

A Study of the Epidemiology, Clinical, and Phenotypic Characteristics of Inflammatory Bowel Disease in the Northen-Central Region of Saudi Arabia

Al-Fawzan,

Al-Radhi,

Al-Omar

et al. 2023

Diagnostics

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Background: Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is becoming increasingly prevalent in Saudi Arabia. However, there is limited data on the characteristics and manifestations of IBD in this population. This study aimed to establish a multi-center database of patients with IBD in the Qassim region of Saudi Arabia to better understand the demographics, prevalence, and manifestations of IBD in this population. Methods: This retrospective study included patients diagnosed with IBD at three healthcare facilities in the Qassim region of Saudi Arabia. The patient’s demographic and clinical characteristics, disease location and behavior, age at diagnosis, medication use, related surgeries, and extraintestinal manifestations were recorded based on the Montreal classification. A total of 257 patients with IBD were included in the study, of which 126 had UC and 131 had CD. Results: Of the 257 patients with IBD, 134 (52.2%) were male and 123 (47.8%) were female. The mean age of patients with CD and UC were 28.74 (range 15–67) and 38.79 (range 15–75) years, respectively. There was a significant difference between all age groups (p < 0.005), with more patients aged over 40 years being diagnosed with UC. UC was most commonly classified as left-sided UC (E2) (60; 47.6%), while the most common location of CD was the ileocolon (L3) (76; 58%). Non-stricturing and non-penetrating CD was the most common behavior (B1) (70; 53.8%). Approximately one-third of the patients with Crohn’s disease developed perianal disease (70; 27.2%), with fistulizing Crohn’s being the most prevalent manifestation (40; 30.5%), followed by abscess formation (10; 7.6%) and fissures (9; 6.8%). The most common extraintestinal manifestation was arthropathy (15; 5.8%). Significant p-values were detected for UC and CD (p = 0.036). Conclusions: This study provides crucial insights into the demographics, patterns, and manifestations of IBD in Saudi Arabia. The findings highlight the need for improved diagnosis, management, and treatment strategies for IBD in this population. The establishment of a multi-center database will help to facilitate future research and improve patient care in Saudi Arabia.

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