Lower-Fluence, Higher-Density versus Higher-Fluence, Lower-Density Treatment with a 10,600-nm Carbon Dioxide Fractional Laser System: A Split-Face, Evaluator-Blinded Study

Abstract

Higher-energy, lower-density laser settings seem to be more effective than lower-energy, higher-density settings for acne scars and enlarged pores, although our results do not constitute a conclusive comparison of the two different modes of CO(2) FS.

Fractional photothermolysis for the treatment of facial wrinkles – searching for optimal treatment parameters in a randomized study in the split‐face design

“…The consensus recommendations make no clear statement on the treatment of periorbital wrinkles [4]. A significant difference between both sides of the face was not found in this study [14]; the authors suspect that this was due to the low number of participants. For the treatment of periorbital wrinkles no comparative studies on optimizing treatment parameters exist to date.…”

“…Treatment with higher energy per MTZ and lower density appears to be more effective in the treatment of periorbital wrinkles than treatment with lower energy per MTZ and higher density with identical total energy per unit surface area. A study by Jung et al confirmed similar results [14]. These recommendations are usually based on therapeutic experience and not on evidencebased data.…”

Micro-Mechanical Fractional Skin Rejuvenation

“…39 Some researchers have found improved clinical outcomes with higher fluences and lower densities. 40 The 23-gauge coring needle resulted in a 27 percent increase in collagen content when compared with the 25-gauge needle (data not shown). Future studies need to be performed to elucidate the role of size and coverage.…”

Efficacy and safety of a single treatment using a 10,600-nm carbon dioxide fractional laser for mild-to-moderate atrophic acne scars in Asian skin

“…In a small study comparing the efficacy and safety of a low-fluence, highdensity CO 2 fractional system with those of high-fluence, lowdensity treatment for acne scars, the clinical results seemed to be more pronounced in the latter group. 18 Fractional photothermolysis is an effective modality for the treatment of a variety of conditions, including photoaging and acne scarring, although the results have all been based on multiple treatments. 6,10,11,19 Previous reports on CO 2 ablative resurfacing have involved at least three sessions.…”