Lower extremity strength, systemic inflammation and all-cause mortality: Application to the “fat but fit” paradigm using cross-sectional and longitudinal designs

Buckner, Samuel L.; Loenneke, Jeremy P.; Loprinzi, Paul D.

doi:10.1016/j.physbeh.2015.06.012

Cited by 17 publications

(12 citation statements)

References 20 publications

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“…However, whether LES continues to demonstrate protective effects on mortality among those with higher levels of sedentary, is, at this point, unknown. Consistent with previous work on this topic (Buckner et al, 2015), LES was inversely associated with all-cause mortality among the entire sample, and this association was not attenuated when considering leisure-time sedentary behavior. Further, there was no evidence of a multiplicative interaction effect of LES and leisure-time sedentary behavior on allcause mortality.…”

Section: Discussionsupporting

confidence: 89%

“…Previous work has demonstrated that lower extremity strength (LES) is an independent predictor of mortality (Artero et al, 2011;Buckner, Loenneke, & Loprinzi, 2015;Katzmarzyk & Craig, 2002;Ruiz et al, 2008;Swallow et al, 2007). Emerging work also demonstrates that sedentary behavior is predictive of early mortality, even independent of moderate-to-vigorous physical activity (Katzmarzyk, Church, Craig, & Bouchard, 2009;Matthews et al, 2012;Patel et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Lower extremity muscular strength, sedentary behavior, and mortality

Loprinzi

2016

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To examine whether lower extremity strength (LES) is predictive of all-cause mortality, independent of physical activity and among those with vary levels of sedentary behavior. Data from the 1999-2002 National Health and Nutrition Examination Survey was used (N = 2768; 50-85 years). Peak isokinetic knee extensor strength was objectively measured, sedentary behavior and physical activity were self-reported, and mortality was assessed via the National Death Index, with followup through 2011. Participants were followed for up to 12.6 years with the weighted average follow-up period lasting 9.9 years (standard error, 1.13). In the sample, 321,996 person-months occurred with a mortality rate of 2.1 deaths per 1000 person-months. After adjustments (including physical activity), for every 15 N increase in LES, participants had a 7 % reduced risk of all-cause mortality (HR = 0.93; 95 % CI 0.91-0.95; P < 0.001). When adding a three-level sedentary behavior variable (< 2, 2-4, 5+ h/day) as a covariate in this model, results were unchanged (HR = 0.93; 95 % CI 0.92-0.96; P < 0.001). Similarly, when sedentary behavior was included as a continuous covariate in the model, results regarding the relationship between LES and mortality were unchanged (HR = 0.94; 95 % CI 0.91-0.96; P < 0.001). There was no evidence of statistical interaction between LES and sedentary behavior on all-cause mortality (HR interaction = 1.01; 95 % CI 0.92-1.10; P = 0.88). LES was inversely associated with all-cause mortality, and this association was unchanged when considering the participant's sedentary behavior.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Lower extremity muscular strength, sedentary behavior, and mortality

Loprinzi

2016

AGE

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“…Participation in such exercise and the increased strength and muscle mass it produces has been evidenced to reduce the risk of numerous morbidities [1, 2] in addition to all-cause mortality [3–8]. Thus, understanding which RT approaches are most efficacious is of considerable interest.…”

Section: Introductionmentioning

confidence: 99%

A comparison of low volume ‘high-intensity-training’ and high volume traditional resistance training methods on muscular performance, body composition, and subjective assessments of training

et al. 2016

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Most studies of resistance training (RT) examine methods that do not resemble typical training practices of persons participating in RT. Ecologically valid RT programs more representative of such practices are seldom compared. This study compared two such approaches to RT. Thirty participants (males, n = 13; females, n = 17) were randomised to either a group performing low volume 'High Intensity Training' (HIT; n = 16) or high volume 'Body-building' (3ST; n = 14) RT methods 2x/week for 10 weeks. Outcomes included muscular performance, body composition, and participant's subjective assessments. Both HIT and 3ST groups improved muscular performance significantly (as indicated by 95% confidence intervals) with large effect sizes (ES; 0.97 to 1.73 and 0.88 to 1.77 respectively). HIT had significantly greater muscular performance gains for 3 of 9 tested exercises compared with 3ST (p < 0.05) and larger effect sizes for 8 of 9 exercises. Body composition did not significantly change in either group. However, effect sizes for whole body muscle mass changes were slightly more favourable in the HIT group compared with the 3ST group (0.27 and -0.34 respectively) in addition to whole body fat mass (0.03 and 0.43 respectively) and whole body fat percentage (-0.10 and -0.44 respectively). Significant muscular performance gains can be produced using either HIT or 3ST. However, muscular performance gains may be greater when using HIT. Future research should look to identify which components of ecologically valid RT programs are primarily responsible for these differences in outcome.

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“…It is based on the realization of specific movements with an established load at a constant speed. It has shown a direct relationship between isokinetic strength in the lower limbs and lower risk of all-cause mortality [92].…”

Section: Maximum Strengthmentioning

confidence: 99%

Fitness Assessment as an Anti-Aging Marker: A Narrative Review

Amaro‐Gahete¹,

De-la-O²,

Jurado‐Fasoli³

et al. 2017

J Gerontol Geriatr Res

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Aging is a natural, physiological, and inevitable process, but it can be also influenced. Although aging is not a disease, it has several characteristics that could indicate so, such as a functional decline at different levels, which may determine clinical manifestations, and it is associated with several disease processes. Consequently, it is essential to create and adopt strategies to delay the aging process. Nowadays, any strategy adopted without including physical exercise seems inconceivable. Recent studies published in relation to this population have shown that the maintenance of acceptable levels of physical fitness is associated with the prevention of many of premature aging consequences, good rates of health, and quality of life of the person. cardiorespiratory fitness and muscular strength (as physical fitness components) are excellent life expectancy and quality of life predictors. Therefore, reaching a good fitness level is the most powerful clinical method to prevent and delay the aging process. Not only their years to live increase, but also their quality, with health and without diseases or mobility dependence.

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Lower extremity strength, systemic inflammation and all-cause mortality: Application to the “fat but fit” paradigm using cross-sectional and longitudinal designs

Cited by 17 publications

References 20 publications

Lower extremity muscular strength, sedentary behavior, and mortality

Lower extremity muscular strength, sedentary behavior, and mortality

A comparison of low volume ‘high-intensity-training’ and high volume traditional resistance training methods on muscular performance, body composition, and subjective assessments of training

Fitness Assessment as an Anti-Aging Marker: A Narrative Review

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