Lower Extremity Osteoarthritis

Raveendran, Reshmi; Nelson, Amanda

doi:10.18043/ncm.78.5.332

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Current understanding attributes lower limb arteriosclerosis obliterans to vascular lesions arising from various factors, perpetuating ischemia and hypoxia in the affected limb. The intricate interplay between degenerative changes in the arterial layers results in adverse outcomes for patients, necessitating a deeper comprehension of the underlying mechanisms [4][5][6]. Amid the molecular orchestrations, the sirtuin 1 (Sirt1) signaling pathway emerges as a pivotal player in the regulation of vascular regeneration and repair [7,8].…”

Section: Introductionmentioning

confidence: 99%

MiR-34a ameliorates arterial blood flow in rats with lower limb arteriosclerosis obliterans via Sirt1 signaling pathway

Tuo Xu,

Changwei Zheng,

Yongkang Wu

et al. 2024

Cell Mol Biol (Noisy-le-grand)

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In this study, we investigated the impact of microRNA-34a (miR-34a) on lower limb arteriosclerosis obliterans in rats through the Sirtuin 1 (Sirt1) signaling pathway. Thirty-six Sprague-Dawley rats were divided into normal, model, and miR-34a mimics groups. Rats in the normal group were raised normally, while the model group underwent lower limb arteriosclerosis obliterans induction and received saline injections. The miR-34a mimics group also underwent arteriosclerosis obliterans modeling but received miR-34a mimics injections. Immunohistochemistry revealed significantly increased vascular endothelial growth factor (VEGF) expression in both model and miR-34a mimics groups compared to the normal group, with the miR-34a mimics group showing higher levels. Western blotting indicated elevated Sirt1 protein expression in both non-normal groups, with the miR-34a mimics group exhibiting significantly higher levels. Quantitative polymerase chain reaction (qPCR) demonstrated higher levels of miR-34a, VEGF mRNA, and Sirt1 mRNA in the model group compared to the normal group, but significantly lower levels than the miR-34a mimics group. Enzyme-linked immunosorbent assay (ELISA) showed increased VEGF content in the model group compared to the normal group but decreased compared to the miR-34a mimics group. Hemorrheological detection revealed a reduced PU index in both non-normal groups compared to the normal group, with a significant increase in the miR-34a mimics group compared to the model group. Overall, miR-34a upregulation enhanced VEGF expression in rat blood vessels, ameliorating arterial blood flow in lower limb arteriosclerosis obliterans through the Sirt1 signaling pathway.

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Section: Introductionmentioning

confidence: 99%

MiR-34a ameliorates arterial blood flow in rats with lower limb arteriosclerosis obliterans via Sirt1 signaling pathway

Tuo Xu,

Changwei Zheng,

Yongkang Wu

et al. 2024

Cell Mol Biol (Noisy-le-grand)

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“…Many organizations have developed OA treatment recommendations in an effort to guide delivery of evidence-based care [7,8]. Table 1 summarizes OA treatments based on published guidelines and clinical expertise [9]. The objective of this paper is to summarize what is known about adherence to OA treatment guidelines within realworld clinical settings.…”

Section: Introductionmentioning

confidence: 99%

Gaps in appropriate use of treatment strategies in osteoarthritis

Allen¹,

Golightly

White

2017

Best Practice & Research Clinical Rheumatology

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Risk factors of post discharge falls in patients undergoing total knee arthroplasty: An integrative review

Sadiq,

Noor,

Akram

2024

BMR

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BACKGROUND: Total knee arthroplasty (TKA) is a widely performed surgical procedure aimed at alleviating pain and restoring functionality in individuals suffering from knee osteoarthritis. Despite substantial benefits of TKA, patients are exposed to potential risks, including the occurrence of falls during their recovery period following discharge from the hospital. OBJECTIVE: This integrative review endeavors to comprehensively investigate the existing body of literature to identify and assess the diverse factors that contribute to occurrence of post-discharge falls among TKA patients. Through the synthesis of available research, this study seeks to offer valuable insights that can guide clinical practices and interventions designed to mitigate the incidence of post-TKA falls, ultimately enhancing patient outcomes and quality of healthcare. METHODS: An integrative review was conducted and databases were searched including Pubmed, PEDro, Cochrane, and SPORTDiscus from 2000 to 2024. A thorough search was performed to retrieve articles missed through databases as well as unpublished grey literature. Methodological quality assessment was performed using Newcastle-Ottawa Scale for Case Control and Cohort studies and AXIS tool for cross-sectional study. RESULTS: Eleven articles finally met the inclusion criteria and were included in the review based on eligibility. There were 8 cohort studies (7 prospective cohorts, 1 retrospective cohort), 2 case control studies, and 1 cross-sectional study. The prospective cohort studies included in the review collected data in real-time as events occurred, making them particularly relevant for studying post-TKA falls. CONCLUSION: Patients who underwent TKA are at risk of post-discharge falls. Several key risk factors have been identified, including advancing age, female gender, reduced proprioception, psychiatric disorders, living alone, and knee pain in the operated knee. It is important to recognize that the significance of these risk factors can vary depending on individual circumstances and contexts.

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Lower Extremity Osteoarthritis

Cited by 3 publications

References 18 publications

MiR-34a ameliorates arterial blood flow in rats with lower limb arteriosclerosis obliterans via Sirt1 signaling pathway

MiR-34a ameliorates arterial blood flow in rats with lower limb arteriosclerosis obliterans via Sirt1 signaling pathway

Gaps in appropriate use of treatment strategies in osteoarthritis

Risk factors of post discharge falls in patients undergoing total knee arthroplasty: An integrative review

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