Lower esophageal sphincter pressures in patients of bronchial asthma and its correlation with spirometric parameters: a case-control study

Dua, Shelka; Mohan, Latika

doi:10.3109/02770903.2015.1088548

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…For example, among individuals with disorders such as asthma and OSA, the high respiratory effort of these disorders is known to strain the lower esophageal sphincter and thereby lead to nGER. [11,32,33] Also, as supported by our findings, OSA may directly cause wheezing. This may be mediated through systemic inflammation caused by OSA and through harmful effects on the airways from increased respiratory effort associated with breathing events characteristic of OSA.…”

Section: Pap and Nger Effects On Wheezingsupporting

confidence: 88%

“…However, it is possible that nGOR and wheezing either have a common causative factor or that wheezing may cause nGOR. For example, among individuals with disorders such as asthma and OSA, the high respiratory effort of these disorders is known to strain the lower oesophageal sphincter and thereby lead to nGOR [ 11 , 32 , 33 ]. Also, as supported by our findings, OSA may directly cause wheezing.…”

Section: Discussionmentioning

confidence: 99%

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Positive airway pressure treatment affects respiratory symptoms and gastro-oesophageal reflux: the Icelandic Sleep Apnea Cohort Study

Emilsson,

Aspelund,

Janson

et al. 2023

ERJ Open Res

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AimTo study the effect of positive airway pressure (PAP) treatment on nocturnal gastroesophageal reflux (nGER) and respiratory symptoms among clinical OSA patients.Methods822 newly diagnosed patients with OSA referred for PAP treatment were recruited. 732 subjects had a 2-year follow-up visit with CPAP compliance data collected (366 full PAP users, 366 partial/non-PAP users). They answered questionnaires, including reporting of nGER, sleep and respiratory symptoms, and general health. Patients with nGER symptoms once a week or more were defined as “with nGER”. Those without nGER symptoms and nGER medication were defined as “no nGER”. Others were defined as “possible nGER”.ResultsPAP treatment among full users resulted in a decreased presence of nGER (adjusted odds ratio (OR) [95% CI]: 0.58 [0.40–0.86]) and wheezing (0.56 [0.35–0.88]) at two-year follow-up, compared with partial/non-PAP users. Decrease in nGER, both among full- and partial/non-users of PAP treatment, associated with a decrease in productive morning cough (4.70 [2.22–9.99]) and a decrease in chronic bronchitis (3.86 [1.74–8.58]), but not decreased wheezing (0.90 [0.39–2.08]). A mediation analysis found that PAP treatment directly led to a decrease in wheezing, not mediated through nGER. Conversely, PAP treatment decreased productive cough mediated through a decrease in nGER.ConclusionIn an unselected group of OSA patients, PAP treatment for two years is associated with a decrease in nGER and respiratory symptoms. The PAP treatment itself associates with less wheezing. A decrease in nGER by PAP treatment is associated with a decrease in productive cough.

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Section: Pap and Nger Effects On Wheezingsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Positive airway pressure treatment affects respiratory symptoms and gastro-oesophageal reflux: the Icelandic Sleep Apnea Cohort Study

Emilsson,

Aspelund,

Janson

et al. 2023

ERJ Open Res

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“…Impedance studies in asthma have shown acid and non-acid reflux to occur with equal frequency [43]. Manometric studies have confirmed a lower LOS pressure in asthmatic patients compared to healthy controls that correlates with low forced expiratory volume in 1 s (FEV 1 ) and may contribute to deterioration of spirometry in asthmatics [44].…”

Section: Reflux Disease and Asthmamentioning

confidence: 99%

Current therapies for gastro-oesophageal reflux in the setting of chronic lung disease: state of the art review

et al. 2020

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The inter-relationship between chronic respiratory disease and reflux disease in the airway reflux paradigm is extremely complex and remains poorly characterised. Reflux disease is reported to cause or contribute to the severity of a number of respiratory tract diseases including laryngeal disorders, sinusitis, chronic cough, asthma, COPD, idiopathic pulmonary fibrosis, cystic fibrosis, bronchiectasis and bronchiolitis obliterans post lung transplant. It is now appreciated that reflux disease is not simply caused by liquid acid reflux but rather by a variety of chemical refluxates originating from the stomach and duodenum due to a number of different mechanisms. Reflux disease can be challenging to diagnose, particularly proving its role in the causation of direct respiratory epithelial damage. Significant advances in oesophageal assessment and gastric biomarkers have emerged in recent years as our understanding increases. There are a number of treatments available for reflux disease, both medical and surgical, but there is a paucity of large randomised trials to evaluate their efficacy in the setting of chronic respiratory disease. Everyday clinical practice, however, informs us that treatment failure in reflux disease is common. This clinical review summarises associations between reflux disease in the setting of chronic respiratory diseases and examines available evidence regarding potential therapeutic strategies.

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Distinguishing Asthma from Comorbid Conditions in Older Adults

Seggev

2019

Treatment of Asthma in Older Adults

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Lower esophageal sphincter pressures in patients of bronchial asthma and its correlation with spirometric parameters: a case-control study

Cited by 3 publications

References 26 publications

Positive airway pressure treatment affects respiratory symptoms and gastro-oesophageal reflux: the Icelandic Sleep Apnea Cohort Study

Positive airway pressure treatment affects respiratory symptoms and gastro-oesophageal reflux: the Icelandic Sleep Apnea Cohort Study

Current therapies for gastro-oesophageal reflux in the setting of chronic lung disease: state of the art review

Distinguishing Asthma from Comorbid Conditions in Older Adults

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