Lower endothelial progenitor cell number, family history of cardiovascular disease and reduced HDL-cholesterol levels are associated with shorter leukocyte telomere length in healthy young adults

Dei, Alessandra; Spigoni, Valentina; Franzini, Laura; Preti, Milena; Ardigò, Diego; Derlindati, Eleonora; Metra, Marco; Monti, Lucilla D.; Dell’Era, Patrizia; Gnudi, Luigi; Zavaroni, Ivana

doi:10.1016/j.numecd.2011.04.005

Cited by 37 publications

(19 citation statements)

References 22 publications

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“…Consistent with this hypothesis, Di Cas et al reported an association between shorter LTL and lower circulating CD34 + PC counts in a small group of healthy young subjects. 38 In our larger study, we have confirmed and expanded this observation in patients with CAD. Although these findings suggest that LTL might be a determinant of the circulating stem cells pool, it predicts adverse outcomes independent of circulating PCs.…”

Section: Discussionsupporting

confidence: 71%

Telomere Shortening, Regenerative Capacity, and Cardiovascular Outcomes

Hammadah

Mheid

Wilmot

et al. 2017

Circulation Research

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Rationale Leucocyte telomere length (LTL) is a biological marker of aging, and shorter LTL is associated with adverse cardiovascular outcomes. Reduced regenerative capacity has been proposed as a mechanism. Bone marrow-derived circulating progenitor cells (PCs) are involved in tissue repair and regeneration. Objective To examine the relationship between LTL and PCs, and their impact on adverse cardiovascular outcomes. Methods and Results We measured LTL by quantitative PCR in 566 outpatients (age 63±9 years, 76% male) with coronary artery disease (CAD). Circulating PCs were enumerated by flow cytometry. After adjustment for age, gender, race, BMI, smoking and previous myocardial infarction, a shorter LTL was associated with a lower CD34+ cell count: for each 10% shorter LTL, CD34+ levels were 5.2% lower (p<0.001). After adjustment for the aforementioned factors, both short LTL (

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Section: Discussionsupporting

confidence: 71%

Telomere Shortening, Regenerative Capacity, and Cardiovascular Outcomes

Hammadah

Mheid

Wilmot

et al. 2017

Circulation Research

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“…SSBs have been known to increase oxidative stress and systemic inflammation, both processes that can influence telomere attrition (13, 14). Telomere shortening in response to, and perhaps contributing to, these disease processes has been reported, reflecting the overall burden of cardiometabolic disease (27, 44, 45). Our results suggest that another link between sugar-sweetened soda consumption and metabolic disease may be through shortened telomere length, a biomarker and mechanism of cellular aging (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

Soda and Cell Aging: Associations Between Sugar-Sweetened Beverage Consumption and Leukocyte Telomere Length in Healthy Adults From the National Health and Nutrition Examination Surveys

et al. 2014

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Objectives We tested whether leukocyte telomere length maintenance, which underlies healthy cellular aging, provides a link between sugar-sweetened beverage (SSB) consumption and risk of cardiometabolic disease. We examined cross-sectional associations between consumption of SSBs, diet soda and fruit juice and telomere length in a nationally representative sample of healthy adults. Methods The study population included 5,309 adults, aged 20 to 65 years, with no prior history of diabetes or cardiovascular disease, from the 1999–2002 National Health and Nutrition Examination Surveys. Leukocyte telomere length was assayed from DNA specimens. Diet was assessed using 24-hour dietary recalls. Associations were examined using multivariate linear regression for the outcome of log-transformed telomere length. Results After adjustment for sociodemographic and health-related characteristics, sugar-sweetened soda consumption was associated with shorter telomeres (β=−0.010, 95% CI −0.020, −0.001, P=0.04). Consumption of 100% fruit juice was marginally associated with longer telomeres (β= 0.016, 95% CI −0.000, 0.033). No significant associations were observed between consumption of diet sodas or non-carbonated sugar-sweetened beverages and telomere length. Conclusions Regular consumption of sugar-sweetened sodas may influence metabolic disease development through accelerated cell aging.

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“…This association has also been confirmed in animal models (22, 23). TL has also been associated with disease states including coronary artery disease (24, 25) and cardiovascular aging (26), which have both been associated with shortened TL. Additionally, smoking, obesity (27), type 2 diabetes (28), and even short sleep duration (29) have been associated with accelerated telomere shorting, all of which are risk factors for disease.…”

Section: Discussionmentioning

confidence: 99%

Telomere Length of Recipients and Living Kidney Donors and Chronic Graft Dysfunction in Kidney Transplants

Oetting

Guan²,

Schladt

et al. 2014

Transplantation

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Background A biological marker that would allow clinicians to determine the length of time an allograft will remain functional after transplantation would greatly aid the ability to stratify donors by risk and to use biologically “young” allografts in young recipients, maximizing the use of this rare resource. Telomere length (TL) has been proposed to be such a marker to determine the biological age of a tissue. Methods We genotyped DNA from 1805 recipients and 1038 living kidney donors for TL to determine the association of TL with acute rejection (AR), chronic graft dysfunction (CGD), and graft failure of kidney allografts. DNA was isolated from peripheral blood white blood cells and TL was measured in DNA using the multiplexed monochrome quantitative polymerase chain reaction assay. Results As has been previously shown, we found a significant association between log-transformed TL and donor age (P=3.8×10−4) and recipient age (P=5.6×10−8). Univariate and multivariate analysis did not show any significant associations between log-transformed TL in donor or recipient DNA with AR, CGD, or graft failure, although we did observe an association between donor chronological age and CGD (P=0.018). Conclusion Although older allografts have been shown to be at greater risk for AR and CGD, this does not appear to be associated with shorter TL. Different markers will need to be identified to determine how biological age impacts transplant outcome, such as age-related fibrosis or tubular atrophy and tubular loss.

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Lower endothelial progenitor cell number, family history of cardiovascular disease and reduced HDL-cholesterol levels are associated with shorter leukocyte telomere length in healthy young adults

Cited by 37 publications

References 22 publications

Telomere Shortening, Regenerative Capacity, and Cardiovascular Outcomes

Telomere Shortening, Regenerative Capacity, and Cardiovascular Outcomes

Soda and Cell Aging: Associations Between Sugar-Sweetened Beverage Consumption and Leukocyte Telomere Length in Healthy Adults From the National Health and Nutrition Examination Surveys

Telomere Length of Recipients and Living Kidney Donors and Chronic Graft Dysfunction in Kidney Transplants

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